{"id":"https://openalex.org/W7126103580","doi":"https://doi.org/10.1109/bibm66473.2025.11356944","title":"LAMA-AD: Label-Aware Multi-Agent Alzheimer's Disease Diagnosis with Counterfactual Reasoning","display_name":"LAMA-AD: Label-Aware Multi-Agent Alzheimer's Disease Diagnosis with Counterfactual Reasoning","publication_year":2025,"publication_date":"2025-12-15","ids":{"openalex":"https://openalex.org/W7126103580","doi":"https://doi.org/10.1109/bibm66473.2025.11356944"},"language":null,"primary_location":{"id":"doi:10.1109/bibm66473.2025.11356944","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356944","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110764585","display_name":"Chun-Lin Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunlin Lu","raw_affiliation_strings":["School of Computer Science and Engineering,Central South University,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering,Central South University,Changsha,China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124265386","display_name":"Yongheng Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongheng Zhang","raw_affiliation_strings":["School of Computer Science and Engineering,Central South University,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering,Central South University,Changsha,China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124291349","display_name":"Yao Li","orcid":null},"institutions":[{"id":"https://openalex.org/I11838497","display_name":"Aviation Industry Corporation of China (China)","ror":"https://ror.org/02wq41p38","country_code":"CN","type":"company","lineage":["https://openalex.org/I11838497"]},{"id":"https://openalex.org/I4210141264","display_name":"Shanghai Civil Aviation College","ror":"https://ror.org/03kkh3m26","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141264"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Li","raw_affiliation_strings":["Shanghai Aviation Electric Co., Ltd, Aviation Industry Corporation of China,Shanghai,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Aviation Electric Co., Ltd, Aviation Industry Corporation of China,Shanghai,China","institution_ids":["https://openalex.org/I11838497","https://openalex.org/I4210141264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048356362","display_name":"Sheng Wang","orcid":"https://orcid.org/0000-0002-0439-5199"},"institutions":[{"id":"https://openalex.org/I11838497","display_name":"Aviation Industry Corporation of China (China)","ror":"https://ror.org/02wq41p38","country_code":"CN","type":"company","lineage":["https://openalex.org/I11838497"]},{"id":"https://openalex.org/I4210141264","display_name":"Shanghai Civil Aviation College","ror":"https://ror.org/03kkh3m26","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141264"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng Wang","raw_affiliation_strings":["Shanghai Aviation Electric Co., Ltd, Aviation Industry Corporation of China,Shanghai,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Aviation Electric Co., Ltd, Aviation Industry Corporation of China,Shanghai,China","institution_ids":["https://openalex.org/I11838497","https://openalex.org/I4210141264"]}]},{"author_position":"last","author":{"id":null,"display_name":"Libo Qin","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Libo Qin","raw_affiliation_strings":["School of Computer Science and Engineering,Central South University,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering,Central South University,Changsha,China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2586","last_page":"2593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.2818000018596649,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.2818000018596649,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10028","display_name":"Topic Modeling","score":0.19339999556541443,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.08579999953508377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/counterfactual-thinking","display_name":"Counterfactual thinking","score":0.9402999877929688},{"id":"https://openalex.org/keywords/limiting","display_name":"Limiting","score":0.5072000026702881},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.4666000008583069},{"id":"https://openalex.org/keywords/counterfactual-conditional","display_name":"Counterfactual conditional","score":0.445499986410141},{"id":"https://openalex.org/keywords/clinical-practice","display_name":"Clinical Practice","score":0.3961000144481659},{"id":"https://openalex.org/keywords/model-based-reasoning","display_name":"Model-based reasoning","score":0.36489999294281006},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.35350000858306885}],"concepts":[{"id":"https://openalex.org/C108650721","wikidata":"https://www.wikidata.org/wiki/Q1783253","display_name":"Counterfactual thinking","level":2,"score":0.9402999877929688},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5080999732017517},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.5072000026702881},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.4666000008583069},{"id":"https://openalex.org/C71889745","wikidata":"https://www.wikidata.org/wiki/Q1783264","display_name":"Counterfactual conditional","level":3,"score":0.445499986410141},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.42179998755455017},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.3961000144481659},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3896999955177307},{"id":"https://openalex.org/C37335422","wikidata":"https://www.wikidata.org/wiki/Q6888134","display_name":"Model-based reasoning","level":3,"score":0.36489999294281006},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.35350000858306885},{"id":"https://openalex.org/C82157600","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic test","level":2,"score":0.33959999680519104},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3292999863624573},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.32120001316070557},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.3122999966144562},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.3102000057697296},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.29649999737739563},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.29260000586509705},{"id":"https://openalex.org/C177769412","wikidata":"https://www.wikidata.org/wiki/Q278090","display_name":"Prior probability","level":3,"score":0.28360000252723694},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.2800999879837036},{"id":"https://openalex.org/C195344581","wikidata":"https://www.wikidata.org/wiki/Q2555318","display_name":"Automated reasoning","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C2776372474","wikidata":"https://www.wikidata.org/wiki/Q508291","display_name":"Simplicity","level":2,"score":0.2572999894618988}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm66473.2025.11356944","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356944","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Quality Education","score":0.4093371331691742,"id":"https://metadata.un.org/sdg/4"}],"awards":[{"id":"https://openalex.org/G1105303547","display_name":null,"funder_award_id":"92570120,62306342","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2396845832","https://openalex.org/W2905035821","https://openalex.org/W2965717703","https://openalex.org/W4206046172","https://openalex.org/W4381384569","https://openalex.org/W4384561707","https://openalex.org/W4385570088","https://openalex.org/W4389520213","https://openalex.org/W4389523828","https://openalex.org/W4391358537","https://openalex.org/W4393160078","https://openalex.org/W4402713111","https://openalex.org/W4403353492","https://openalex.org/W4403979995","https://openalex.org/W4404782209","https://openalex.org/W4408325956","https://openalex.org/W4410068147","https://openalex.org/W4415536450"],"related_works":[],"abstract_inverted_index":{"The":[0],"early":[1],"and":[2,52,82,86,133,148],"accurate":[3,150],"diagnosis":[4],"of":[5,21,92,135],"Alzheimer's":[6,61],"Disease":[7,62],"(AD)":[8],"is":[9],"essential":[10],"for":[11,34,124],"effective":[12],"intervention,":[13],"yet":[14],"remains":[15],"challenging":[16],"due":[17],"to":[18,112,144],"the":[19,41,78,131,136],"complexity":[20],"clinical":[22,75],"data.":[23],"While":[24],"large":[25],"language":[26],"models":[27],"(LLMs)":[28],"have":[29],"become":[30],"a":[31,68],"promising":[32],"avenue":[33],"medical":[35,43],"diagnostics,":[36],"existing":[37],"approaches":[38],"often":[39],"overlook":[40],"implicit":[42],"knowledge":[44],"embedded":[45],"in":[46,117],"diagnostic":[47,50,79,115,151],"labels,":[48],"limiting":[49],"reliability":[51],"interpretability.":[53],"Motivated":[54],"by":[55,107],"this,":[56],"we":[57],"introduce":[58],"Label-Aware":[59,96],"Multi-Agent":[60,97],"Diagnosis":[63],"with":[64],"Counterfactual":[65,139],"Reasoning":[66],"(LAMA-AD),":[67],"labelaware":[69],"multi-agent":[70],"framework":[71],"that":[72],"explicitly":[73],"incorporates":[74],"priors":[76],"into":[77],"reasoning":[80,126],"process":[81],"integrates":[83],"both":[84,130],"factual":[85],"counterfactual":[87],"reasoning.":[88],"Specifically,":[89],"LAMA-AD":[90],"consists":[91],"two":[93],"components:":[94],"(1)":[95],"Diagnosis,":[98],"which":[99],"deploys":[100],"multiple":[101],"independent":[102],"analyst":[103],"agents,":[104],"each":[105],"guided":[106],"distinct":[108],"label-aware":[109],"prior":[110],"knowledge,":[111],"explore":[113],"diverse":[114],"hypotheses":[116,143],"parallel.":[118],"Each":[119],"agent":[120],"provides":[121],"supporting":[122],"facts":[123],"its":[125],"process,":[127],"thereby":[128],"enhancing":[129],"depth":[132],"robustness":[134],"analysis.":[137],"(2)":[138],"Reasoningsystematically":[140],"assesses":[141],"conflicting":[142],"yield":[145],"stable,":[146],"interpretable,":[147],"highly":[149],"conclusions.":[152],"Experimental":[153],"verification":[154],"confirms":[155],"LAMA-AD's":[156],"superiority":[157],"over":[158],"established":[159],"methods.":[160],"Analysis":[161],"further":[162],"shows":[163],"it":[164],"generates":[165],"semantically":[166],"rich,":[167],"logically":[168],"consistent":[169],"explanations.":[170]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2026-01-30T00:00:00"}
