{"id":"https://openalex.org/W7126043785","doi":"https://doi.org/10.1109/bibm66473.2025.11356760","title":"Beyond H&amp;E: Unlocking Pathological Insights with Polarization Imaging","display_name":"Beyond H&amp;E: Unlocking Pathological Insights with Polarization Imaging","publication_year":2025,"publication_date":"2025-12-15","ids":{"openalex":"https://openalex.org/W7126043785","doi":"https://doi.org/10.1109/bibm66473.2025.11356760"},"language":"en","primary_location":{"id":"doi:10.1109/bibm66473.2025.11356760","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356760","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042892828","display_name":"Yao Du","orcid":null},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yao Du","raw_affiliation_strings":["The Hong Kong University of Science and Technology,Hong Kong SAR,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hong Kong University of Science and Technology,Hong Kong SAR,China","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124282107","display_name":"Jiaxin Zhuang","orcid":null},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Jiaxin Zhuang","raw_affiliation_strings":["The Hong Kong University of Science and Technology,Hong Kong SAR,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hong Kong University of Science and Technology,Hong Kong SAR,China","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001233601","display_name":"Xiaoyu Zheng","orcid":"https://orcid.org/0000-0003-4286-9196"},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Xiaoyu Zheng","raw_affiliation_strings":["The Hong Kong University of Science and Technology,Hong Kong SAR,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hong Kong University of Science and Technology,Hong Kong SAR,China","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102279909","display_name":"Jing Cong","orcid":"https://orcid.org/0000-0002-1544-7097"},"institutions":[{"id":"https://openalex.org/I4210157323","display_name":"South China Institute of Collaborative Innovation","ror":"https://ror.org/04jnpk588","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210157323","https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Cong","raw_affiliation_strings":["Beijing Institute of Collaborative Innovation,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Collaborative Innovation,China","institution_ids":["https://openalex.org/I4210157323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124233448","display_name":"Limei Guo","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Limei Guo","raw_affiliation_strings":["Peking University Health Science Center, Peking University Third Hospital,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University Health Science Center, Peking University Third Hospital,China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052668737","display_name":"Chao He","orcid":"https://orcid.org/0000-0001-9654-830X"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chao He","raw_affiliation_strings":["University of Oxford,United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford,United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102671299","display_name":"Lin Luo","orcid":"https://orcid.org/0000-0001-5752-329X"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Luo","raw_affiliation_strings":["Peking University,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University,China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124235032","display_name":"Xiaomeng Li","orcid":null},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Xiaomeng Li","raw_affiliation_strings":["The Hong Kong University of Science and Technology,Hong Kong SAR,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hong Kong University of Science and Technology,Hong Kong SAR,China","institution_ids":["https://openalex.org/I200769079"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2138","last_page":"2143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12050","display_name":"Optical Polarization and Ellipsometry","score":0.6959999799728394,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12050","display_name":"Optical Polarization and Ellipsometry","score":0.6959999799728394,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.11969999969005585,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.04580000042915344,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gold-standard","display_name":"Gold standard (test)","score":0.4927999973297119},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.48969998955726624},{"id":"https://openalex.org/keywords/digital-pathology","display_name":"Digital pathology","score":0.48489999771118164},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.459199994802475},{"id":"https://openalex.org/keywords/polarization","display_name":"Polarization (electrochemistry)","score":0.42809998989105225},{"id":"https://openalex.org/keywords/medical-imaging","display_name":"Medical imaging","score":0.39879998564720154},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.3610999882221222},{"id":"https://openalex.org/keywords/feature-extraction","display_name":"Feature extraction","score":0.3528999984264374},{"id":"https://openalex.org/keywords/modality","display_name":"Modality (human\u2013computer interaction)","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6316999793052673},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5781000256538391},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.4927999973297119},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.48969998955726624},{"id":"https://openalex.org/C2777522853","wikidata":"https://www.wikidata.org/wiki/Q5276128","display_name":"Digital pathology","level":2,"score":0.48489999771118164},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.459199994802475},{"id":"https://openalex.org/C205049153","wikidata":"https://www.wikidata.org/wiki/Q2698605","display_name":"Polarization (electrochemistry)","level":2,"score":0.42809998989105225},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.42289999127388},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.39879998564720154},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.3610999882221222},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.3479999899864197},{"id":"https://openalex.org/C69744172","wikidata":"https://www.wikidata.org/wiki/Q860822","display_name":"Image fusion","level":3,"score":0.3292999863624573},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.32760000228881836},{"id":"https://openalex.org/C92630104","wikidata":"https://www.wikidata.org/wiki/Q4115103","display_name":"Optical imaging","level":2,"score":0.31859999895095825},{"id":"https://openalex.org/C125743686","wikidata":"https://www.wikidata.org/wiki/Q108779","display_name":"Birefringence","level":2,"score":0.3183000087738037},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.2881999909877777},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.2809999883174896},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.27959999442100525},{"id":"https://openalex.org/C2983453321","wikidata":"https://www.wikidata.org/wiki/Q40397","display_name":"Biological tissue","level":2,"score":0.2732999920845032},{"id":"https://openalex.org/C83665646","wikidata":"https://www.wikidata.org/wiki/Q42139305","display_name":"Feature vector","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.2687000036239624},{"id":"https://openalex.org/C33954974","wikidata":"https://www.wikidata.org/wiki/Q486494","display_name":"Sensor fusion","level":2,"score":0.2605000138282776},{"id":"https://openalex.org/C112416745","wikidata":"https://www.wikidata.org/wiki/Q974213","display_name":"Digital imaging","level":5,"score":0.25859999656677246},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25429999828338623},{"id":"https://openalex.org/C159620131","wikidata":"https://www.wikidata.org/wiki/Q1938983","display_name":"Spatial analysis","level":2,"score":0.25029999017715454},{"id":"https://openalex.org/C3020205268","wikidata":"https://www.wikidata.org/wiki/Q1038886","display_name":"Imaging technique","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibm66473.2025.11356760","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356760","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},{"id":"pmh:oai:repository.hkust.edu.hk:1783.1-170629","is_oa":false,"landing_page_url":"http://repository.hkust.edu.hk/ir/Record/1783.1-170629","pdf_url":null,"source":{"id":"https://openalex.org/S4306401796","display_name":"Rare & Special e-Zone (The Hong Kong University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I200769079","host_organization_name":"Hong Kong University of Science and Technology","host_organization_lineage":["https://openalex.org/I200769079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Conference paper"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8560870210","display_name":null,"funder_award_id":"62306254","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W2050921210","https://openalex.org/W2912934043","https://openalex.org/W3043075211","https://openalex.org/W3080341489","https://openalex.org/W3128210037","https://openalex.org/W3133515922","https://openalex.org/W3159481202","https://openalex.org/W3173898803","https://openalex.org/W3176828726","https://openalex.org/W3182833528","https://openalex.org/W3201635246","https://openalex.org/W3203168750","https://openalex.org/W3207836794","https://openalex.org/W3211190672","https://openalex.org/W4251320132","https://openalex.org/W4312709677","https://openalex.org/W4386076317","https://openalex.org/W4387225748","https://openalex.org/W4390322800","https://openalex.org/W4391945515","https://openalex.org/W4392404203","https://openalex.org/W4392947521","https://openalex.org/W4394593087","https://openalex.org/W4399504524","https://openalex.org/W4401510972","https://openalex.org/W4402220065","https://openalex.org/W4402373303","https://openalex.org/W4402703096","https://openalex.org/W4403089117","https://openalex.org/W4403365584","https://openalex.org/W4403998581","https://openalex.org/W4414349754","https://openalex.org/W4414380836"],"related_works":[],"abstract_inverted_index":{"Histopathology":[0],"image":[1],"analysis":[2],"is":[3,172],"fundamental":[4],"to":[5,35,118,129],"digital":[6],"pathology,":[7,180],"with":[8,111],"hematoxylin":[9],"and":[10,20,29,37,49,57,71,132,159,175,184,202],"eosin":[11],"(H&E)":[12],"staining":[13],"as":[14],"the":[15,115,156,163,197],"gold":[16],"standard":[17],"for":[18,43,193,199],"diagnostic":[19,95,186],"prognostic":[21],"assessments.":[22],"While":[23],"H&E":[24,110],"imaging":[25,69,171],"effectively":[26],"highlights":[27],"cellular":[28],"tissue":[30,38,120],"structures,":[31],"it":[32],"lacks":[33],"sensitivity":[34],"birefringence":[36],"anisotropy,":[39],"which":[40],"are":[41],"crucial":[42],"assessing":[44],"collagen":[45],"organization,":[46],"fiber":[47],"alignment,":[48],"microstructural":[50],"alterations-key":[51],"indicators":[52],"of":[53,76,83,152],"tumor":[54],"progression,":[55],"fibrosis,":[56],"other":[58],"pathological":[59,91],"conditions.":[60],"To":[61],"bridge":[62],"this":[63,99],"gap,":[64],"we":[65,101],"construct":[66],"a":[67,73,104,125,173,190],"polarization":[68,84,112,170],"system":[70],"curate":[72],"new":[74],"dataset":[75,158],"over":[77],"13,000":[78],"paired":[79],"Polar-H&E":[80],"images.":[81],"Visualizations":[82],"properties":[85],"reveal":[86],"distinctive":[87],"optical":[88],"signatures":[89],"in":[90,178],"tissues,":[92],"underscoring":[93],"its":[94],"value.":[96],"Building":[97],"on":[98,155,162],"dataset,":[100],"propose":[102],"PolarHE,":[103],"dual-modality":[105],"fusion":[106],"framework":[107],"that":[108,169],"integrates":[109],"imaging,":[113],"leveraging":[114],"latter's":[116],"ability":[117],"enhance":[119],"characterization.":[121],"Our":[122],"approach":[123,144],"employs":[124],"feature":[126,182],"decomposition":[127],"strategy":[128],"disentangle":[130],"common":[131],"modality-specific":[133],"features,":[134],"ensuring":[135],"effective":[136],"multimodal":[137,194],"representation":[138,183],"learning.":[139],"Through":[140],"comprehensive":[141],"validation,":[142],"our":[143],"significantly":[145],"outperforms":[146],"previous":[147],"methods,":[148],"achieving":[149],"an":[150],"accuracy":[151],"86.70":[153],"%":[154,161],"Chaoyang":[157],"89.06":[160],"MHIST":[164],"dataset.":[165],"These":[166],"results":[167],"demonstrate":[168],"powerful":[174],"underutilized":[176],"modality":[177],"computational":[179],"enriching":[181],"improving":[185],"accuracy.":[187],"PolarHE":[188],"establishes":[189],"promising":[191],"direction":[192],"learning,":[195],"paving":[196],"way":[198],"more":[200],"interpretable":[201],"generalizable":[203],"pathology":[204],"models.":[205]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2026-01-30T00:00:00"}
