{"id":"https://openalex.org/W7126100498","doi":"https://doi.org/10.1109/bibm66473.2025.11356608","title":"Leveraging Negative Sequential Patterns for Advanced Genomic Analysis and Classification","display_name":"Leveraging Negative Sequential Patterns for Advanced Genomic Analysis and Classification","publication_year":2025,"publication_date":"2025-12-15","ids":{"openalex":"https://openalex.org/W7126100498","doi":"https://doi.org/10.1109/bibm66473.2025.11356608"},"language":null,"primary_location":{"id":"doi:10.1109/bibm66473.2025.11356608","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356608","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124204750","display_name":"Wenxi Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenxi Zhu","raw_affiliation_strings":["Jinan University,Guangzhou,China,510632"],"affiliations":[{"raw_affiliation_string":"Jinan University,Guangzhou,China,510632","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124188763","display_name":"Wensheng Gan","orcid":null},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wensheng Gan","raw_affiliation_strings":["Jinan University,Guangzhou,China,510632"],"affiliations":[{"raw_affiliation_string":"Jinan University,Guangzhou,China,510632","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102589904","display_name":"Zhenlian Qi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210122543","display_name":"Guangdong Polytechnic Normal University","ror":"https://ror.org/02pcb5m77","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210122543"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenlian Qi","raw_affiliation_strings":["Guangdong Eco-Engineering Polytechnic,Guangzhou,China,510520"],"affiliations":[{"raw_affiliation_string":"Guangdong Eco-Engineering Polytechnic,Guangzhou,China,510520","institution_ids":["https://openalex.org/I4210122543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5124204750"],"corresponding_institution_ids":["https://openalex.org/I159948400"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6522285,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"6913","last_page":"6920"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.31540000438690186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.31540000438690186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.15629999339580536,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.09529999643564224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.8751999735832214},{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.7378000020980835},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5677000284194946},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5188000202178955},{"id":"https://openalex.org/keywords/perspective","display_name":"Perspective (graphical)","score":0.4260999858379364},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4052000045776367}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.8751999735832214},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.7378000020980835},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5799999833106995},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5677000284194946},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5202000141143799},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5188000202178955},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4916999936103821},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.4260999858379364},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4052000045776367},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.40049999952316284},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3734000027179718},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3458999991416931},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3294000029563904},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.32839998602867126},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.3239000141620636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31139999628067017},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.3052000105381012},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.2766999900341034}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm66473.2025.11356608","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356608","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.6951914429664612,"id":"https://metadata.un.org/sdg/10"}],"awards":[{"id":"https://openalex.org/G4460898826","display_name":null,"funder_award_id":"62272196","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1532202009","https://openalex.org/W2026562765","https://openalex.org/W2170505850","https://openalex.org/W2295598076","https://openalex.org/W2323326409","https://openalex.org/W2587325413","https://openalex.org/W2605595174","https://openalex.org/W2732139758","https://openalex.org/W2761430568","https://openalex.org/W2803163798","https://openalex.org/W3012772854","https://openalex.org/W3048300562","https://openalex.org/W3127797560","https://openalex.org/W3184368927","https://openalex.org/W3185619636","https://openalex.org/W3186353921","https://openalex.org/W3189185839","https://openalex.org/W4236236547","https://openalex.org/W4236459334","https://openalex.org/W4285612676","https://openalex.org/W4289766427","https://openalex.org/W4313452391","https://openalex.org/W4318814398","https://openalex.org/W4353055924","https://openalex.org/W4366977840","https://openalex.org/W4391026416","https://openalex.org/W4392970630","https://openalex.org/W4394675060","https://openalex.org/W4396678936","https://openalex.org/W4398177119","https://openalex.org/W4400360993","https://openalex.org/W4400943345","https://openalex.org/W4402568735","https://openalex.org/W4403381224","https://openalex.org/W4403966511","https://openalex.org/W4404644013"],"related_works":[],"abstract_inverted_index":{"Viruses":[0],"represent":[1],"the":[2,150,165,177,185],"most":[3],"abundant":[4],"biological":[5],"entities":[6],"and":[7,25,51,103,115,138,171,195,202],"play":[8],"pivotal":[9],"roles":[10],"in":[11,118,155],"microbial":[12],"ecosystems.":[13],"As":[14],"prominent":[15],"human":[16,23],"pathogens,":[17],"they":[18],"are":[19],"closely":[20],"linked":[21],"to":[22,164,176],"morbidity":[24],"mortality.":[26],"Accurate":[27],"identification":[28],"of":[29,91,153,187],"viral":[30,33,74,93,119,199],"sequences":[31,35,90],"from":[32,88],"genome":[34,200],"is":[36],"essential,":[37],"yet":[38],"existing":[39],"genome-based":[40],"mod-els-mainly":[41],"relying":[42],"on":[43,55,78],"composition":[44],"or":[45,57],"frequency":[46],"features-often":[47],"show":[48],"limited":[49],"interpretability":[50],"lower":[52],"accuracy,":[53],"especially":[54],"complex":[56],"imbalanced":[58],"datasets.":[59],"To":[60],"address":[61],"these":[62,97],"limitations,":[63],"we":[64,122],"propose":[65,123],"GeneNSPCla":[66,110],"(Genomic":[67],"Negative":[68],"Sequential":[69],"Patternbased":[70],"Classification),":[71],"a":[72,124,193],"novel":[73],"classification":[75],"framework":[76],"based":[77],"negative":[79,125,142,167],"sequential":[80,143,190],"patterns":[81],"(NSPs)":[82],"that":[83,149],"extracts":[84],"discriminative":[85],"absence-based":[86,189],"features":[87],"nucleotide":[89],"RNA":[92],"genomes.":[94],"By":[95],"transforming":[96],"NSPs":[98],"into":[99,106],"numerical":[100],"feature":[101],"vectors":[102],"integrating":[104],"them":[105],"multiple":[107],"supervised":[108],"classifiers,":[109],"effectively":[111],"captures":[112],"both":[113],"presence":[114],"absence":[116],"signals":[117],"sequences.":[120],"Furthermore,":[121],"pattern":[126,168,179],"mining":[127,169,180],"algorithm,":[128],"GONPM,":[129],"for":[130,198],"processing":[131],"genomic":[132],"data,":[133],"which":[134],"can":[135],"discover":[136],"longer":[137],"more":[139],"biologically":[140],"meaningful":[141],"patterns.":[144],"The":[145],"experimental":[146],"results":[147],"demonstrate":[148],"average":[151],"accuracy":[152],"GONPM":[154],"8":[156],"classifiers":[157],"has":[158],"improved":[159],"by":[160,172],"5.25":[161],"%":[162,174],"compared":[163,175],"original":[166],"algorithm":[170],"19.97":[173],"positive":[178],"algorithm.":[181],"These":[182],"findings":[183],"highlight":[184],"effectiveness":[186],"incorporating":[188],"information,":[191],"providing":[192],"new":[194],"complementary":[196],"perspective":[197],"analysis":[201],"classification.":[203]},"counts_by_year":[],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2026-01-30T00:00:00"}
