{"id":"https://openalex.org/W7126115637","doi":"https://doi.org/10.1109/bibm66473.2025.11356598","title":"Frequency-Adaptive Analysis and Peak-Guided Attention for Drug-Target Interaction Prediction","display_name":"Frequency-Adaptive Analysis and Peak-Guided Attention for Drug-Target Interaction Prediction","publication_year":2025,"publication_date":"2025-12-15","ids":{"openalex":"https://openalex.org/W7126115637","doi":"https://doi.org/10.1109/bibm66473.2025.11356598"},"language":null,"primary_location":{"id":"doi:10.1109/bibm66473.2025.11356598","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356598","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124186125","display_name":"Yu Du","orcid":null},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Du","raw_affiliation_strings":["Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,Hubei,PR China,430079"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,Hubei,PR China,430079","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003578876","display_name":"Song Jiang","orcid":"https://orcid.org/0000-0003-2151-0977"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song Jiang","raw_affiliation_strings":["Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,Hubei,PR China,430079"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,Hubei,PR China,430079","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xianjun Shen","orcid":null},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianjun Shen","raw_affiliation_strings":["Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,Hubei,PR China,430079"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,Hubei,PR China,430079","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121420414","display_name":"Weizhong Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weizhong Zhao","raw_affiliation_strings":["Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,Hubei,PR China,430079"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,Hubei,PR China,430079","institution_ids":["https://openalex.org/I40963666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40963666"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1645","last_page":"1648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pooling","display_name":"Pooling","score":0.7487000226974487},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.5530999898910522},{"id":"https://openalex.org/keywords/fusion","display_name":"Fusion","score":0.35580000281333923},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3025999963283539},{"id":"https://openalex.org/keywords/discrete-cosine-transform","display_name":"Discrete cosine transform","score":0.27140000462532043}],"concepts":[{"id":"https://openalex.org/C70437156","wikidata":"https://www.wikidata.org/wiki/Q7228652","display_name":"Pooling","level":2,"score":0.7487000226974487},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6029999852180481},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5857999920845032},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.5530999898910522},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.35580000281333923},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35409998893737793},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3025999963283539},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.29580000042915344},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.28139999508857727},{"id":"https://openalex.org/C2221639","wikidata":"https://www.wikidata.org/wiki/Q2877","display_name":"Discrete cosine transform","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.26350000500679016},{"id":"https://openalex.org/C38764148","wikidata":"https://www.wikidata.org/wiki/Q17098245","display_name":"Interaction information","level":2,"score":0.2567000091075897}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm66473.2025.11356598","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356598","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.597981870174408}],"awards":[{"id":"https://openalex.org/G3221909189","display_name":null,"funder_award_id":"62472192,62372205","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2065927292","https://openalex.org/W2785947426","https://openalex.org/W2972411752","https://openalex.org/W3018980093","https://openalex.org/W3028589594","https://openalex.org/W3096561213","https://openalex.org/W4318981550","https://openalex.org/W4321748128","https://openalex.org/W4392693790","https://openalex.org/W4400268828","https://openalex.org/W4404585832","https://openalex.org/W4406312972","https://openalex.org/W4411925407","https://openalex.org/W4412363244","https://openalex.org/W4412659725"],"related_works":[],"abstract_inverted_index":{"Identifying":[0],"drug\u2013target":[1],"interactions":[2],"(DTIs)":[3],"is":[4],"critical":[5],"for":[6,50,59,65],"discovery":[7],"and":[8,17,52,62,84],"repurposing.":[9],"Existing":[10],"deep":[11],"models":[12],"often":[13],"ignore":[14],"frequency-domain":[15,32],"structure":[16],"rely":[18],"on":[19],"global":[20,60],"pooling":[21],"that":[22],"dilutes":[23],"binding-critical":[24],"signals.":[25],"We":[26],"present":[27],"TriPeakDTI,":[28],"which":[29],"couples":[30],"adaptive":[31],"analysis":[33],"with":[34],"a":[35],"peak-guided":[36,72],"attention":[37],"mechanism.":[38],"Using":[39],"the":[40],"discrete":[41],"cosine":[42],"transform":[43],"(DCT),":[44],"TriPeakDTI":[45,94],"learns":[46],"per-modality":[47],"spectral":[48],"weights":[49],"drugs":[51],"targets":[53],"to":[54],"capture":[55],"multi-scale":[56],"patterns\u2014low":[57],"frequencies":[58,64],"conformations":[61],"high":[63],"local":[66],"flexibility\u2014during":[67],"single-modal":[68],"extraction.":[69],"A":[70],"bidirectional,":[71],"fusion":[73],"module":[74],"preserves":[75],"token-level":[76],"interaction":[77],"evidence":[78],"via":[79],"peak":[80],"detection,":[81],"cross-modal":[82],"alignment,":[83],"strength-aware":[85],"aggregation,":[86],"preventing":[87],"information":[88],"washout.":[89],"Across":[90],"three":[91],"benchmark":[92],"datasets,":[93],"outperforms":[95],"seven":[96],"state-of-theart":[97],"methods.":[98]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2026-01-30T00:00:00"}
