{"id":"https://openalex.org/W7126113207","doi":"https://doi.org/10.1109/bibm66473.2025.11356564","title":"Integrating Epigenetic and Phenotypic Features for Biological Age Estimation in Cancer Patients via Multimodal Learning","display_name":"Integrating Epigenetic and Phenotypic Features for Biological Age Estimation in Cancer Patients via Multimodal Learning","publication_year":2025,"publication_date":"2025-12-15","ids":{"openalex":"https://openalex.org/W7126113207","doi":"https://doi.org/10.1109/bibm66473.2025.11356564"},"language":null,"primary_location":{"id":"doi:10.1109/bibm66473.2025.11356564","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356564","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124255913","display_name":"Shuyue Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shuyue Jiang","raw_affiliation_strings":["Emory University,Atlanta,GA,USA,30322"],"affiliations":[{"raw_affiliation_string":"Emory University,Atlanta,GA,USA,30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124259037","display_name":"Wenjing Ma","orcid":null},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenjing Ma","raw_affiliation_strings":["University of Michigan,Ann Arbor,MI,USA,48109"],"affiliations":[{"raw_affiliation_string":"University of Michigan,Ann Arbor,MI,USA,48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124206272","display_name":"Shaojun Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaojun Yu","raw_affiliation_strings":["Emory University,Atlanta,GA,USA,30322"],"affiliations":[{"raw_affiliation_string":"Emory University,Atlanta,GA,USA,30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045324437","display_name":"Chang Su","orcid":"https://orcid.org/0000-0002-8704-1512"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chang Su","raw_affiliation_strings":["Emory University,Atlanta,GA,USA,30322"],"affiliations":[{"raw_affiliation_string":"Emory University,Atlanta,GA,USA,30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078669479","display_name":"Runze Yan","orcid":"https://orcid.org/0000-0002-6558-4567"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Runze Yan","raw_affiliation_strings":["Emory University,Atlanta,GA,USA,30322"],"affiliations":[{"raw_affiliation_string":"Emory University,Atlanta,GA,USA,30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124225126","display_name":"Jiaying Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaying Lu","raw_affiliation_strings":["Emory University,Atlanta,GA,USA,30322"],"affiliations":[{"raw_affiliation_string":"Emory University,Atlanta,GA,USA,30322","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5124255913"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67409724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1005","last_page":"1011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.46050000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.46050000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.09239999949932098,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biological-age","display_name":"Biological age","score":0.8440999984741211},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.7714999914169312},{"id":"https://openalex.org/keywords/multimodal-therapy","display_name":"Multimodal therapy","score":0.6680999994277954},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5637999773025513},{"id":"https://openalex.org/keywords/survivorship-curve","display_name":"Survivorship curve","score":0.5600000023841858},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.5300999879837036},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.4625999927520752},{"id":"https://openalex.org/keywords/epigenesis","display_name":"Epigenesis","score":0.4462999999523163},{"id":"https://openalex.org/keywords/estimation","display_name":"Estimation","score":0.4316999912261963}],"concepts":[{"id":"https://openalex.org/C2991747559","wikidata":"https://www.wikidata.org/wiki/Q4915075","display_name":"Biological age","level":2,"score":0.8440999984741211},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7714999914169312},{"id":"https://openalex.org/C4441509","wikidata":"https://www.wikidata.org/wiki/Q6418787","display_name":"Multimodal therapy","level":2,"score":0.6680999994277954},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5637999773025513},{"id":"https://openalex.org/C172400760","wikidata":"https://www.wikidata.org/wiki/Q332796","display_name":"Survivorship curve","level":3,"score":0.5600000023841858},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5300999879837036},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4625999927520752},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.4462999999523163},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4456999897956848},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4456999897956848},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.4316999912261963},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.4250999987125397},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41119998693466187},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.40610000491142273},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34279999136924744},{"id":"https://openalex.org/C2910988560","wikidata":"https://www.wikidata.org/wiki/Q12094637","display_name":"Biological sex","level":2,"score":0.3409999907016754},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.33799999952316284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3319000005722046},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.33079999685287476},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32499998807907104},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3061999976634979},{"id":"https://openalex.org/C3017819807","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy aging","level":2,"score":0.3012999892234802},{"id":"https://openalex.org/C20864712","wikidata":"https://www.wikidata.org/wiki/Q667800","display_name":"Biological motion","level":3,"score":0.30090001225471497},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2948000133037567},{"id":"https://openalex.org/C2993482122","wikidata":"https://www.wikidata.org/wiki/Q5031456","display_name":"Cancer survivorship","level":4,"score":0.2874000072479248},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.27950000762939453},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.27720001339912415},{"id":"https://openalex.org/C130947863","wikidata":"https://www.wikidata.org/wiki/Q5533121","display_name":"Gene\u2013environment interaction","level":4,"score":0.2639999985694885},{"id":"https://openalex.org/C66782513","wikidata":"https://www.wikidata.org/wiki/Q864601","display_name":"Biomedicine","level":2,"score":0.25600001215934753},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.2556000053882599},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.2524999976158142},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2517000138759613}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm66473.2025.11356564","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356564","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7423708438873291,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1554335923","https://openalex.org/W1974047233","https://openalex.org/W2121091193","https://openalex.org/W2122825543","https://openalex.org/W2126525177","https://openalex.org/W2155320075","https://openalex.org/W2158485828","https://openalex.org/W2173367702","https://openalex.org/W2194775991","https://openalex.org/W2199275482","https://openalex.org/W2295598076","https://openalex.org/W2410374774","https://openalex.org/W2767377392","https://openalex.org/W2898256996","https://openalex.org/W2949100461","https://openalex.org/W2983046534","https://openalex.org/W2989381487","https://openalex.org/W3147894994","https://openalex.org/W3195084370","https://openalex.org/W4214879506","https://openalex.org/W4224276389","https://openalex.org/W4387965553","https://openalex.org/W4389519939","https://openalex.org/W4391027505","https://openalex.org/W4400762160","https://openalex.org/W4402050298","https://openalex.org/W4406170795","https://openalex.org/W4416960800"],"related_works":[],"abstract_inverted_index":{"Biological":[0],"age,":[1],"which":[2],"may":[3],"be":[4],"older":[5],"or":[6],"younger":[7],"than":[8],"chronological":[9],"age":[10,56,74,88,109],"due":[11],"to":[12,53],"factors":[13],"such":[14],"as":[15,21,100],"genetic":[16],"predisposition,":[17],"environmental":[18],"exposures,":[19],"serves":[20],"a":[22,44,101],"meaningful":[23],"biomarker":[24],"of":[25],"aging":[26],"processes":[27],"and":[28,35,50,62,72,85],"can":[29],"inform":[30],"risk":[31],"stratification,":[32],"treatment":[33],"planning,":[34],"survivorship":[36],"care":[37],"in":[38,111],"cancer":[39,65],"patients.":[40],"We":[41],"propose":[42],"EpiCAge,":[43],"multimodal":[45,103],"framework":[46],"that":[47,79],"integrates":[48],"epigenetic":[49,71],"phenotypic":[51,73],"data":[52],"improve":[54],"biological":[55,108],"prediction.":[57],"Evaluated":[58],"on":[59],"eight":[60],"internal":[61],"four":[63],"external":[64],"cohorts,":[66],"EpiCAge":[67,80,99],"consistently":[68],"outperforms":[69],"existing":[70],"clocks.":[75],"Our":[76],"analyses":[77],"show":[78],"identifies":[81],"biologically":[82],"relevant":[83],"markers,":[84],"its":[86],"derived":[87],"acceleration":[89],"is":[90],"significantly":[91],"associated":[92],"with":[93],"mortality":[94],"risk.":[95],"These":[96],"results":[97],"highlight":[98],"promising":[102],"machine":[104],"learning":[105],"tool":[106],"for":[107],"assessment":[110],"oncology.":[112]},"counts_by_year":[],"updated_date":"2026-02-01T03:34:12.195049","created_date":"2026-01-30T00:00:00"}
