{"id":"https://openalex.org/W7126027479","doi":"https://doi.org/10.1109/bibm66473.2025.11356258","title":"A Novel Bioinformatic Prognostic Biomarker: Cumulative Mutation Burden in Cancer Pathways Independently Predicts Survival in Breast Cancer","display_name":"A Novel Bioinformatic Prognostic Biomarker: Cumulative Mutation Burden in Cancer Pathways Independently Predicts Survival in Breast Cancer","publication_year":2025,"publication_date":"2025-12-15","ids":{"openalex":"https://openalex.org/W7126027479","doi":"https://doi.org/10.1109/bibm66473.2025.11356258"},"language":null,"primary_location":{"id":"doi:10.1109/bibm66473.2025.11356258","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356258","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124277312","display_name":"Chunli Han","orcid":null},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunli Han","raw_affiliation_strings":["Cancer Biobank, Tianjin Medical University Cancer Institute &#x0026; Hospital,Tianjin,China"],"affiliations":[{"raw_affiliation_string":"Cancer Biobank, Tianjin Medical University Cancer Institute &#x0026; Hospital,Tianjin,China","institution_ids":["https://openalex.org/I2802573037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124201728","display_name":"Jiachen Li","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiachen Li","raw_affiliation_strings":["Tianjin No. 1 High School,Tianjin,China"],"affiliations":[{"raw_affiliation_string":"Tianjin No. 1 High School,Tianjin,China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040037670","display_name":"B.Q. Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I193114190","display_name":"Chifeng University","ror":"https://ror.org/05wr48765","country_code":"CN","type":"education","lineage":["https://openalex.org/I193114190"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Boer Chen","raw_affiliation_strings":["Red Flag Middle School,Chifeng,China"],"affiliations":[{"raw_affiliation_string":"Red Flag Middle School,Chifeng,China","institution_ids":["https://openalex.org/I193114190"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5124277312"],"corresponding_institution_ids":["https://openalex.org/I2802573037"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68683184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"4879","last_page":"4883"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.3203999996185303,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.3203999996185303,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.22830000519752502,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.06159999966621399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.8047000169754028},{"id":"https://openalex.org/keywords/multivariate-analysis","display_name":"Multivariate analysis","score":0.614300012588501},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.6079000234603882},{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.5264999866485596},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5242000222206116},{"id":"https://openalex.org/keywords/univariate-analysis","display_name":"Univariate analysis","score":0.48260000348091125},{"id":"https://openalex.org/keywords/survival-analysis","display_name":"Survival analysis","score":0.4724999964237213}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8047000169754028},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6729999780654907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6154000163078308},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.614300012588501},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6079000234603882},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5306000113487244},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.5264999866485596},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5242000222206116},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.48260000348091125},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4724999964237213},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4593999981880188},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44920000433921814},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.38440001010894775},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.3386000096797943},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.328000009059906},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28029999136924744},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.27709999680519104},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26809999346733093},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.25769999623298645},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.2533000111579895}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm66473.2025.11356258","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356258","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5266947150230408,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W2008007733","https://openalex.org/W2106036365","https://openalex.org/W2113948354","https://openalex.org/W2124809259","https://openalex.org/W2135340303","https://openalex.org/W2375577403","https://openalex.org/W2546921687","https://openalex.org/W2553366487","https://openalex.org/W2566168881","https://openalex.org/W2765480939","https://openalex.org/W2775112690","https://openalex.org/W2777930547","https://openalex.org/W2892334526","https://openalex.org/W2982499278","https://openalex.org/W4283270852","https://openalex.org/W4389992545","https://openalex.org/W4414065896","https://openalex.org/W4414127926","https://openalex.org/W4414545387"],"related_works":[],"abstract_inverted_index":{"Breast":[0],"cancer":[1,6,16,51,56,67,243,252],"is":[2,201],"a":[3,9,247],"well-known":[4],"heterogeneous":[5],"type,":[7],"with":[8,26,54,96,147,210],"wide":[10],"range":[11],"of":[12,48,76,132,240,255],"somatic":[13],"mutations.":[14],"Some":[15],"related":[17,52,244],"genes":[18,53,62,245],"have":[19,185],"been":[20],"reported":[21],"to":[22,41,125],"be":[23],"significantly":[24,93],"associated":[25,146],"patient":[27,34,140],"survival,":[28,209],"however,":[29],"their":[30],"cumulative":[31,46,238],"impact":[32],"on":[33,190],"survival":[35,82,95],"remains":[36,161],"unclear.":[37],"Our":[38,233],"study":[39],"aims":[40],"investigate":[42],"the":[43,61,73,101,127,130,172,237],"association":[44,128,160,189],"between":[45,129],"number":[47,75,131,239],"mutations":[49,77,89,105,133,145,200,241],"in":[50,64,171,242],"breast":[55,251],"overall":[57,208],"survival.":[58,135],"We":[59,116,184],"extracted":[60],"involved":[63],"Pathway":[65],"In":[66,81],"from":[68],"KEGG":[69],"database,":[70],"and":[71,90,114,122,134,168,221],"calculated":[72],"total":[74],"within":[78],"those":[79],"genes.":[80],"analysis,":[83],"patients":[84,102,195],"harbored":[85,141],"more":[86,91,142,197],"than":[87,100,143,198],"five":[88],"showed":[92],"worse":[94],"30":[97],"months":[98],"shorter":[99],"without":[103],"any":[104],"(log-rank":[106],"test":[107],"<tex":[108,111,152,177,215,226],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[109,112,153,178,216,227],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$p$</tex>-value":[110],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$=0.048$</tex>":[113],"0.041).":[115],"then":[117],"utilized":[118],"both":[119],"univariate":[120,211],"analysis":[121,124,212,223],"multivariate":[123,173,222],"analyze":[126],"The":[136,159],"results":[137],"indicated":[138,235],"that":[139,194,236],"5":[144,199],"bad":[148],"OS":[149],"(hazard":[150,175,213,224],"ratio,":[151,176,214,225],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$2.25[95":[154],"\\%":[155,180],"\\text{CI},":[156,181],"1.32-3.81],":[157],"\\mathrm{p}=0.003$</tex>).":[158],"statistically":[162],"significant":[163],"after":[164],"controlling":[165],"age,":[166],"ER":[167],"HER2":[169],"status":[170],"model":[174],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$1.92[95":[179],"1.12-3.29],":[182],"p=0.018$</tex>).":[183],"further":[186],"confirmed":[187],"this":[188],"validation":[191],"group,":[192],"proving":[193],"harbor":[196],"indeed":[202],"an":[203],"independent":[204,254],"prognostic":[205],"factor":[206],"for":[207,250],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$1.73[95":[217],"\\%,":[218,229],"1.06-2.82],":[219],"\\mathrm{p}=0.027$</tex>)":[220],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$1.68[95":[228],"1.03-2.75],":[230],"\\mathrm{p}=0.037$</tex>),":[231],"respectively.":[232],"finding":[234],"confers":[246],"poorer":[248],"prognosis":[249],"patients,":[253],"chemotherapy.":[256]},"counts_by_year":[],"updated_date":"2026-02-01T03:34:12.195049","created_date":"2026-01-30T00:00:00"}