{"id":"https://openalex.org/W7126043473","doi":"https://doi.org/10.1109/bibm66473.2025.11356244","title":"Fetal Digital Twin for Drug Resistance Prediction in CYP3A7","display_name":"Fetal Digital Twin for Drug Resistance Prediction in CYP3A7","publication_year":2025,"publication_date":"2025-12-15","ids":{"openalex":"https://openalex.org/W7126043473","doi":"https://doi.org/10.1109/bibm66473.2025.11356244"},"language":null,"primary_location":{"id":"doi:10.1109/bibm66473.2025.11356244","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356244","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124203127","display_name":"Ugochukwu Okoro","orcid":null},"institutions":[{"id":"https://openalex.org/I113508548","display_name":"Albany State University","ror":"https://ror.org/01vme4277","country_code":"US","type":"education","lineage":["https://openalex.org/I113508548"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ugochukwu Okoro","raw_affiliation_strings":["The University at Albany State University of New York,Department of Computer Science,Albany,USA"],"affiliations":[{"raw_affiliation_string":"The University at Albany State University of New York,Department of Computer Science,Albany,USA","institution_ids":["https://openalex.org/I113508548"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017440090","display_name":"Chinwe Ekenna","orcid":"https://orcid.org/0000-0002-7027-6040"},"institutions":[{"id":"https://openalex.org/I113508548","display_name":"Albany State University","ror":"https://ror.org/01vme4277","country_code":"US","type":"education","lineage":["https://openalex.org/I113508548"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chinwe Ekenna","raw_affiliation_strings":["The University at Albany State University of New York,Department of Computer Science,Albany,USA"],"affiliations":[{"raw_affiliation_string":"The University at Albany State University of New York,Department of Computer Science,Albany,USA","institution_ids":["https://openalex.org/I113508548"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5124203127"],"corresponding_institution_ids":["https://openalex.org/I113508548"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7449086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1795","last_page":"1800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7430999875068665,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7430999875068665,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6590999960899353},{"id":"https://openalex.org/keywords/fetus","display_name":"Fetus","score":0.6355000138282776},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.43459999561309814},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.3806999921798706},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.37610000371932983},{"id":"https://openalex.org/keywords/pregnancy","display_name":"Pregnancy","score":0.35659998655319214}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6590999960899353},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6355000138282776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4894999861717224},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4458000063896179},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.43459999561309814},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3806999921798706},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.37610000371932983},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.35659998655319214},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.34950000047683716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3140000104904175},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3118000030517578},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3107999861240387},{"id":"https://openalex.org/C3020359197","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver enzyme","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C2992092908","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug toxicity","level":3,"score":0.2939000129699707},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.2565999925136566},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.25459998846054077}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm66473.2025.11356244","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356244","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8327939510345459,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W2096580672","https://openalex.org/W2142840694","https://openalex.org/W2969295137","https://openalex.org/W2982936646","https://openalex.org/W3033683362","https://openalex.org/W3119219974","https://openalex.org/W3134206589","https://openalex.org/W3146948847","https://openalex.org/W3200915061","https://openalex.org/W3216238012","https://openalex.org/W4210349096","https://openalex.org/W4283740947","https://openalex.org/W4285741853","https://openalex.org/W4295905061","https://openalex.org/W4309355706","https://openalex.org/W4317705143","https://openalex.org/W4318250429","https://openalex.org/W4318667571","https://openalex.org/W4324032847","https://openalex.org/W4382602080","https://openalex.org/W4387737827","https://openalex.org/W4387966880","https://openalex.org/W4390344548","https://openalex.org/W4396849983","https://openalex.org/W4400578872","https://openalex.org/W4402747741","https://openalex.org/W4404497872","https://openalex.org/W4407419977","https://openalex.org/W4407756909","https://openalex.org/W4408635878","https://openalex.org/W4409801681"],"related_works":[],"abstract_inverted_index":{"This":[0],"research":[1],"introduces":[2],"a":[3,22],"web-based":[4],"digital":[5,133],"twin":[6,134],"model":[7,58],"designed":[8],"to":[9,77,92,114,136],"predict":[10],"drug":[11,48,79,125],"resistance":[12],"associated":[13],"with":[14],"CYP3A7":[15,29,42],"variants":[16,40],"in":[17,25,109],"the":[18,32,57,110,117,130],"fetal":[19,26,65,124],"liver.":[20],"As":[21],"key":[23],"enzyme":[24,69,90,121],"hepatic":[27],"metabolism,":[28],"significantly":[30,107],"influences":[31],"pharma-cokinetics":[33],"of":[34,41,120,132],"various":[35],"drugs":[36,100],"during":[37,141],"development.":[38],"Genetic":[39],"can":[43],"alter":[44],"its":[45],"activity,":[46],"impacting":[47],"safety":[49],"and":[50,62,74,88],"efficacy.":[51],"To":[52],"support":[53],"personalized":[54],"treatment":[55],"strategies,":[56],"integrates":[59],"MichaelisMenten":[60],"kinetics":[61],"physiologically":[63],"relevant":[64],"parameters":[66],"such":[67],"as":[68],"expression":[70],"levels,":[71],"liver":[72],"volume,":[73],"gestational":[75],"age":[76],"simulate":[78],"concentration":[80],"dynamics":[81],"over":[82],"time.":[83],"The":[84],"platform":[85],"compares":[86],"wild-type":[87],"resistant":[89],"behaviors":[91],"evaluate":[93],"toxicity":[94,105],"risk.":[95],"Our":[96],"results":[97],"show":[98],"that":[99],"like":[101],"midazolam":[102],"remain":[103],"above":[104],"thresholds":[106],"longer":[108],"CYP3A7*3":[111],"variant":[112],"compared":[113],"CYP3A7*2,":[115],"em-phasizing":[116],"critical":[118],"impact":[119],"polymorphisms":[122],"on":[123],"exposure.":[126],"These":[127],"findings":[128],"highlight":[129],"potential":[131],"models":[135],"inform":[137],"safer":[138],"pharmacological":[139],"decisions":[140],"pregnancy.":[142]},"counts_by_year":[],"updated_date":"2026-02-01T03:34:12.195049","created_date":"2026-01-30T00:00:00"}