{"id":"https://openalex.org/W7126083727","doi":"https://doi.org/10.1109/bibm66473.2025.11356214","title":"Explicit Knowledge-Guided in-Context Learning for Early Detection of Alzheimer's Disease","display_name":"Explicit Knowledge-Guided in-Context Learning for Early Detection of Alzheimer's Disease","publication_year":2025,"publication_date":"2025-12-15","ids":{"openalex":"https://openalex.org/W7126083727","doi":"https://doi.org/10.1109/bibm66473.2025.11356214"},"language":null,"primary_location":{"id":"doi:10.1109/bibm66473.2025.11356214","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356214","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124150746","display_name":"Puzhen Su","orcid":null},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Puzhen Su","raw_affiliation_strings":["College of Computer Science and Technology, National University of Defense Technology,Changsha,China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, National University of Defense Technology,Changsha,China","institution_ids":["https://openalex.org/I170215575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101237510","display_name":"Yongzhu Miao","orcid":null},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongzhu Miao","raw_affiliation_strings":["College of Computer Science and Technology, National University of Defense Technology,Changsha,China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, National University of Defense Technology,Changsha,China","institution_ids":["https://openalex.org/I170215575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041248383","display_name":"Chunxi Guo","orcid":null},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunxi Guo","raw_affiliation_strings":["College of Computer Science and Technology, National University of Defense Technology,Changsha,China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, National University of Defense Technology,Changsha,China","institution_ids":["https://openalex.org/I170215575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124242397","display_name":"Jintao Tang","orcid":null},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jintao Tang","raw_affiliation_strings":["College of Computer Science and Technology, National University of Defense Technology,Changsha,China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, National University of Defense Technology,Changsha,China","institution_ids":["https://openalex.org/I170215575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124166794","display_name":"Shasha Li","orcid":null},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shasha Li","raw_affiliation_strings":["College of Computer Science and Technology, National University of Defense Technology,Changsha,China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, National University of Defense Technology,Changsha,China","institution_ids":["https://openalex.org/I170215575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124268429","display_name":"Ting Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Wang","raw_affiliation_strings":["College of Computer Science and Technology, National University of Defense Technology,Changsha,China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, National University of Defense Technology,Changsha,China","institution_ids":["https://openalex.org/I170215575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5124150746"],"corresponding_institution_ids":["https://openalex.org/I170215575"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.84082727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2926","last_page":"2931"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.39980000257492065,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.39980000257492065,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10028","display_name":"Topic Modeling","score":0.08380000293254852,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.065700002014637,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parsing","display_name":"Parsing","score":0.6237999796867371},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.574400007724762},{"id":"https://openalex.org/keywords/semantics","display_name":"Semantics (computer science)","score":0.47440001368522644},{"id":"https://openalex.org/keywords/task-analysis","display_name":"Task analysis","score":0.4219000041484833},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4036000072956085},{"id":"https://openalex.org/keywords/multi-task-learning","display_name":"Multi-task learning","score":0.3822000026702881},{"id":"https://openalex.org/keywords/language-model","display_name":"Language model","score":0.3522999882698059},{"id":"https://openalex.org/keywords/question-answering","display_name":"Question answering","score":0.3472000062465668}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7621999979019165},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6392999887466431},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.6345000267028809},{"id":"https://openalex.org/C186644900","wikidata":"https://www.wikidata.org/wiki/Q194152","display_name":"Parsing","level":2,"score":0.6237999796867371},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.574400007724762},{"id":"https://openalex.org/C184337299","wikidata":"https://www.wikidata.org/wiki/Q1437428","display_name":"Semantics (computer science)","level":2,"score":0.47440001368522644},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.45339998602867126},{"id":"https://openalex.org/C175154964","wikidata":"https://www.wikidata.org/wiki/Q380077","display_name":"Task analysis","level":3,"score":0.4219000041484833},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4036000072956085},{"id":"https://openalex.org/C28006648","wikidata":"https://www.wikidata.org/wiki/Q6934509","display_name":"Multi-task learning","level":3,"score":0.3822000026702881},{"id":"https://openalex.org/C137293760","wikidata":"https://www.wikidata.org/wiki/Q3621696","display_name":"Language model","level":2,"score":0.3522999882698059},{"id":"https://openalex.org/C44291984","wikidata":"https://www.wikidata.org/wiki/Q1074173","display_name":"Question answering","level":2,"score":0.3472000062465668},{"id":"https://openalex.org/C4554734","wikidata":"https://www.wikidata.org/wiki/Q593744","display_name":"Knowledge base","level":2,"score":0.31709998846054077},{"id":"https://openalex.org/C2983448237","wikidata":"https://www.wikidata.org/wiki/Q1078276","display_name":"Language understanding","level":2,"score":0.31709998846054077},{"id":"https://openalex.org/C45942800","wikidata":"https://www.wikidata.org/wiki/Q245652","display_name":"Ensemble learning","level":2,"score":0.30660000443458557},{"id":"https://openalex.org/C161301231","wikidata":"https://www.wikidata.org/wiki/Q3478658","display_name":"Knowledge representation and reasoning","level":2,"score":0.305400013923645},{"id":"https://openalex.org/C2779439875","wikidata":"https://www.wikidata.org/wiki/Q1078276","display_name":"Natural language understanding","level":3,"score":0.3043999969959259},{"id":"https://openalex.org/C90805587","wikidata":"https://www.wikidata.org/wiki/Q10944557","display_name":"Word (group theory)","level":2,"score":0.30250000953674316},{"id":"https://openalex.org/C136389625","wikidata":"https://www.wikidata.org/wiki/Q334384","display_name":"Supervised learning","level":3,"score":0.2944999933242798},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C195324797","wikidata":"https://www.wikidata.org/wiki/Q33742","display_name":"Natural language","level":2,"score":0.2529999911785126},{"id":"https://openalex.org/C59404180","wikidata":"https://www.wikidata.org/wiki/Q17013334","display_name":"Feature learning","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm66473.2025.11356214","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356214","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6313300709","display_name":null,"funder_award_id":"2025JK2119","funder_id":"https://openalex.org/F4320327777","funder_display_name":"Jiangsu Provincial Key Research and Development Program"}],"funders":[{"id":"https://openalex.org/F4320327777","display_name":"Jiangsu Provincial Key Research and Development Program","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2008301592","https://openalex.org/W2015349939","https://openalex.org/W2074037951","https://openalex.org/W2122328291","https://openalex.org/W3030364939","https://openalex.org/W3097109903","https://openalex.org/W3125401821","https://openalex.org/W3157651102","https://openalex.org/W3192405822","https://openalex.org/W4214601561","https://openalex.org/W4320896605","https://openalex.org/W4402671517","https://openalex.org/W4404792982"],"related_works":[],"abstract_inverted_index":{"Detecting":[0],"Alzheimer's":[1],"Disease":[2],"(AD)":[3],"from":[4,38,95],"narrative":[5],"transcripts":[6],"remains":[7],"a":[8,28,70,132],"challenging":[9],"task":[10,39,51,83],"for":[11],"large":[12],"language":[13,97],"models":[14,98],"(LLMs),":[15],"particularly":[16],"under":[17,195],"out-of-distribution":[18],"(OOD)":[19],"and":[20,45,50,82,113,117,136,162,183],"datascarce":[21],"conditions.":[22,197],"While":[23],"in-context":[24],"learning":[25],"(ICL)":[26],"provides":[27],"parameter-efficient":[29],"alternative":[30],"to":[31,78,100,109,121,139,177],"fine-tuning,":[32],"existing":[33],"ICL":[34,163,169],"approaches":[35],"often":[36],"suffer":[37],"recognition":[40],"failure,":[41],"suboptimal":[42],"demonstration":[43],"selection,":[44,116],"misalignment":[46,124],"between":[47],"label":[48,118,181],"words":[49],"objectives,":[52],"issues":[53],"that":[54,73,156,168],"are":[55],"amplified":[56],"in":[57,85,103,146,171,192],"clinical":[58,193],"domains":[59],"like":[60],"AD":[61,147,153,172],"detection.":[62],"We":[63],"propose":[64],"Explicit":[65],"Knowledge":[66],"In-Context":[67],"Learners":[68],"(EK-ICL),":[69],"novel":[71],"framework":[72],"integrates":[74],"structured":[75],"explicit":[76,190],"knowledge":[77,90,191],"enhance":[79],"reasoning":[80,194],"stability":[81],"alignment":[84,179],"ICL.":[86],"EK-ICL":[87,130,157],"incorporates":[88],"three":[89,152],"components:":[91],"confidence":[92],"scores":[93,108],"derived":[94],"small":[96],"(SLMs)":[99],"ground":[101],"predictions":[102],"task-relevant":[104],"patterns,":[105],"parsing":[106],"feature":[107],"capture":[110],"structural":[111],"differences":[112],"improve":[114],"demo":[115],"word":[119],"replacement":[120],"resolve":[122],"semantic":[123,144],"with":[125],"LLM":[126],"priors.":[127],"In":[128],"addition,":[129],"employs":[131],"parsing-based":[133],"retrieval":[134],"strategy":[135],"ensemble":[137],"prediction":[138],"mitigate":[140],"the":[141,178,187],"effects":[142],"of":[143,180,189],"homogeneity":[145],"transcripts.":[148],"Extensive":[149],"experiments":[150],"across":[151],"datasets":[154],"demonstrate":[155],"significantly":[158],"outperforms":[159],"state-of-the-art":[160],"fine-tuning":[161],"baselines.":[164],"Further":[165],"analysis":[166],"reveals":[167],"performance":[170],"detection":[173],"is":[174],"highly":[175],"sensitive":[176],"semantics":[182],"task-specific":[184],"context,":[185],"underscoring":[186],"importance":[188],"low-resource":[196]},"counts_by_year":[],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2026-01-30T00:00:00"}