{"id":"https://openalex.org/W7126034220","doi":"https://doi.org/10.1109/bibm66473.2025.11356099","title":"Predicting MCI Conversion Status Using Baseline Neuroimaging Scans and Genetics Variations","display_name":"Predicting MCI Conversion Status Using Baseline Neuroimaging Scans and Genetics Variations","publication_year":2025,"publication_date":"2025-12-15","ids":{"openalex":"https://openalex.org/W7126034220","doi":"https://doi.org/10.1109/bibm66473.2025.11356099"},"language":null,"primary_location":{"id":"doi:10.1109/bibm66473.2025.11356099","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356099","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073265844","display_name":"Yan Yang","orcid":"https://orcid.org/0000-0002-3306-3863"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Yang","raw_affiliation_strings":["School of Automation, Northwestern Polytechnical University,Xi&#x0027;an,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Automation, Northwestern Polytechnical University,Xi&#x0027;an,China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068348323","display_name":"Muheng Shang","orcid":"https://orcid.org/0000-0002-9227-7263"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Muheng Shang","raw_affiliation_strings":["School of Automation, Northwestern Polytechnical University,Xi&#x0027;an,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Automation, Northwestern Polytechnical University,Xi&#x0027;an,China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100375979","display_name":"Yuxuan Wang","orcid":"https://orcid.org/0000-0002-1649-6974"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]},{"id":"https://openalex.org/I3132630691","display_name":"Chinese General Hospital College of Nursing and Liberal Arts","ror":"https://ror.org/00fweme20","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I3132630691"]},{"id":"https://openalex.org/I4210101382","display_name":"People's Liberation Army No. 150 Hospital","ror":"https://ror.org/014nsap67","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101382"]},{"id":"https://openalex.org/I4210162172","display_name":"Chinese People\u2019s Liberation Army 263 hospital","ror":"https://ror.org/05b51ak88","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210162172"]}],"countries":["CN","PH"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Chinese People&#x0027;s Liberation Army General Hospital,Department of Radiology,Beijing,China","School of Automation, Northwestern Polytechnical University,Xi&#x0027;an,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese People&#x0027;s Liberation Army General Hospital,Department of Radiology,Beijing,China","institution_ids":["https://openalex.org/I3132630691","https://openalex.org/I4210101382","https://openalex.org/I4210162172"]},{"raw_affiliation_string":"School of Automation, Northwestern Polytechnical University,Xi&#x0027;an,China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124258822","display_name":"Jin Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Zhang","raw_affiliation_strings":["School of Automation, Northwestern Polytechnical University,Xi&#x0027;an,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Automation, Northwestern Polytechnical University,Xi&#x0027;an,China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065859286","display_name":"Hui Li","orcid":"https://orcid.org/0000-0001-9198-3951"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongdong Li","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University,Changsha,China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100375979","display_name":"Yuxuan Wang","orcid":"https://orcid.org/0000-0002-1649-6974"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]},{"id":"https://openalex.org/I3132630691","display_name":"Chinese General Hospital College of Nursing and Liberal Arts","ror":"https://ror.org/00fweme20","country_code":"PH","type":"healthcare","lineage":["https://openalex.org/I3132630691"]},{"id":"https://openalex.org/I4210101382","display_name":"People's Liberation Army No. 150 Hospital","ror":"https://ror.org/014nsap67","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101382"]},{"id":"https://openalex.org/I4210162172","display_name":"Chinese People\u2019s Liberation Army 263 hospital","ror":"https://ror.org/05b51ak88","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210162172"]}],"countries":["CN","PH"],"is_corresponding":false,"raw_author_name":"Yulin Wang","raw_affiliation_strings":["Chinese People&#x0027;s Liberation Army General Hospital,Department of Radiology,Beijing,China","School of Automation, Northwestern Polytechnical University,Xi&#x0027;an,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese People&#x0027;s Liberation Army General Hospital,Department of Radiology,Beijing,China","institution_ids":["https://openalex.org/I3132630691","https://openalex.org/I4210101382","https://openalex.org/I4210162172"]},{"raw_affiliation_string":"School of Automation, Northwestern Polytechnical University,Xi&#x0027;an,China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124262843","display_name":"Lei Du","orcid":null},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Du","raw_affiliation_strings":["School of Automation, Northwestern Polytechnical University,Xi&#x0027;an,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Automation, Northwestern Polytechnical University,Xi&#x0027;an,China","institution_ids":["https://openalex.org/I17145004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"3112","last_page":"3117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8353999853134155,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8353999853134155,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.026599999517202377,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.921500027179718},{"id":"https://openalex.org/keywords/functional-neuroimaging","display_name":"Functional neuroimaging","score":0.49779999256134033},{"id":"https://openalex.org/keywords/default-mode-network","display_name":"Default mode network","score":0.4738999903202057},{"id":"https://openalex.org/keywords/prodromal-stage","display_name":"Prodromal Stage","score":0.4634999930858612},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.4034999907016754},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.35760000348091125},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.3522999882698059},{"id":"https://openalex.org/keywords/baseline","display_name":"Baseline (sea)","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.921500027179718},{"id":"https://openalex.org/C52338299","wikidata":"https://www.wikidata.org/wiki/Q1004354","display_name":"Functional neuroimaging","level":3,"score":0.49779999256134033},{"id":"https://openalex.org/C141516989","wikidata":"https://www.wikidata.org/wiki/Q1182555","display_name":"Default mode network","level":3,"score":0.4738999903202057},{"id":"https://openalex.org/C2910528735","wikidata":"https://www.wikidata.org/wiki/Q1140331","display_name":"Prodromal Stage","level":4,"score":0.4634999930858612},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45010000467300415},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.4034999907016754},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.35760000348091125},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3522999882698059},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.3479999899864197},{"id":"https://openalex.org/C2778373026","wikidata":"https://www.wikidata.org/wiki/Q4738819","display_name":"Alzheimer's Disease Neuroimaging Initiative","level":4,"score":0.31470000743865967},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3140999972820282},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3107999861240387},{"id":"https://openalex.org/C120843803","wikidata":"https://www.wikidata.org/wiki/Q4955807","display_name":"Brain activity and meditation","level":3,"score":0.3107999861240387},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.3075000047683716},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3050999939441681},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.28859999775886536},{"id":"https://openalex.org/C182752723","wikidata":"https://www.wikidata.org/wiki/Q1474590","display_name":"Functional imaging","level":2,"score":0.28610000014305115},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.2777000069618225},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.2572999894618988},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.25540000200271606},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25360000133514404},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm66473.2025.11356099","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356099","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1964793333","https://openalex.org/W1974874858","https://openalex.org/W1987909254","https://openalex.org/W2000658130","https://openalex.org/W2008929650","https://openalex.org/W2017033087","https://openalex.org/W2052226124","https://openalex.org/W2059980851","https://openalex.org/W2096063777","https://openalex.org/W2098290597","https://openalex.org/W2100831964","https://openalex.org/W2115779804","https://openalex.org/W2143090565","https://openalex.org/W2156220037","https://openalex.org/W2185729964","https://openalex.org/W2327949797","https://openalex.org/W2541781202","https://openalex.org/W2582524520","https://openalex.org/W2792608425","https://openalex.org/W2887719025","https://openalex.org/W3001510487","https://openalex.org/W3007931728","https://openalex.org/W3043837784","https://openalex.org/W4211139529","https://openalex.org/W4295750005","https://openalex.org/W4311782097","https://openalex.org/W4320482315","https://openalex.org/W4323832104","https://openalex.org/W4328049732","https://openalex.org/W4378782144","https://openalex.org/W4388199641"],"related_works":[],"abstract_inverted_index":{"Mild":[0],"cognitive":[1],"impairment":[2],"(MCI)":[3],"is":[4,32,59],"a":[5,72,119],"prodromal":[6],"stage":[7,58],"of":[8,35,95,111,139,180],"Alzheimer's":[9,156],"disease":[10],"(AD),":[11],"but":[12],"not":[13],"all":[14],"MCI":[15,24,29,51,195],"subjects":[16,26,31],"develop":[17],"into":[18],"AD":[19,214],"finally.":[20],"Therefore,":[21],"distinguishing":[22],"progressive":[23,137],"(pMCI)":[25],"from":[27,154],"stable":[28],"(sMCI)":[30],"an":[33,50,96,112],"area":[34],"intense":[36],"interest,":[37],"which":[38,210],"may":[39],"provide":[40],"targeted":[41],"treatments":[42],"for":[43],"at-risk":[44],"individuals.":[45],"On":[46],"this":[47,115],"account,":[48],"building":[49],"conversion":[52,93,196],"prediction":[53,169],"model":[54],"at":[55],"the":[56,92,102,108,136,142,155,164,178,181,194,198],"early":[57],"particularly":[60],"important.":[61],"The":[62,98],"neuroimaging":[63,99,128],"data,":[64],"especially":[65],"multi-modal":[66,126],"ones,":[67],"has":[68,167],"proven":[69],"to":[70,204],"be":[71],"great":[73],"alternative":[74],"in":[75],"predicting":[76],"MCIs'":[77],"conversion.":[78],"In":[79,114],"addition,":[80],"genetic":[81,131],"variations":[82],"such":[83],"as":[84],"Single":[85],"Nucleotide":[86],"Polymorphism":[87],"(SNP)":[88],"can":[89,134],"also":[90],"imply":[91],"risk":[94,110],"individual.":[97,113],"data":[100,129],"represents":[101],"current":[103],"status,":[104],"while":[105],"SNPs":[106],"convey":[107],"inherited":[109],"paper,":[116],"we":[117],"propose":[118],"deep":[120],"representative":[121],"fusion":[122],"method":[123,166],"that":[124,163,177],"combines":[125],"baseline":[127],"and":[130,148,186,197],"variations.":[132],"It":[133],"predict":[135],"status":[138],"MCIs":[140],"over":[141],"following":[143],"two":[144],"years,":[145,150],"three":[146],"years":[147],"four":[149],"respectively.":[151],"Experimental":[152],"results":[153],"Disease":[157],"Neuroimaging":[158],"Initiative":[159],"(ADNI)":[160],"database":[161],"demonstrate":[162],"proposed":[165],"better":[168],"capability":[170],"than":[171],"comparison":[172],"methods.":[173],"Moreover,":[174],"findings":[175],"show":[176],"stability":[179],"default":[182],"mode":[183],"network":[184,189],"(DMN)":[185],"ventral":[187],"attention":[188],"(VAN)":[190],"are":[191,202,211],"correlated":[192],"with":[193,213],"learned":[199],"imaging":[200],"representations":[201],"related":[203],"minimental":[205],"state":[206],"examination":[207],"(MMSE)":[208],"scores":[209],"associated":[212],"progression.":[215]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2026-01-30T00:00:00"}
