{"id":"https://openalex.org/W4406261462","doi":"https://doi.org/10.1109/bibm62325.2024.10822777","title":"Multi-source Data-driven Drug Repositioning based on Deep Self-attention Network","display_name":"Multi-source Data-driven Drug Repositioning based on Deep Self-attention Network","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406261462","doi":"https://doi.org/10.1109/bibm62325.2024.10822777"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10822777","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822777","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100687673","display_name":"Binbin Chen","orcid":"https://orcid.org/0000-0002-9584-0082"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Chen","raw_affiliation_strings":["Hunan Normal University,College of Information Science and Engineering,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Normal University,College of Information Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I173759888","https://openalex.org/I3130607311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086050506","display_name":"Qiu Xiao","orcid":"https://orcid.org/0000-0002-4726-7154"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiu Xiao","raw_affiliation_strings":["Hunan Normal University,College of Information Science and Engineering,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Normal University,College of Information Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I173759888","https://openalex.org/I3130607311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043855304","display_name":"Zhuo Huang","orcid":"https://orcid.org/0000-0001-9198-4778"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuo Huang","raw_affiliation_strings":["Hunan Normal University,College of Information Science and Engineering,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Normal University,College of Information Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I173759888","https://openalex.org/I3130607311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113114299","display_name":"Tuo Xiong","orcid":null},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tuo Xiong","raw_affiliation_strings":["Hunan Normal University,College of Information Science and Engineering,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Normal University,College of Information Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I173759888","https://openalex.org/I3130607311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082687032","display_name":"Yide Yang","orcid":"https://orcid.org/0000-0003-3297-1306"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yide Yang","raw_affiliation_strings":["Hunan Normal University,School of Medicine,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Normal University,School of Medicine,Changsha,China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033371544","display_name":"Jiancheng Zhong","orcid":"https://orcid.org/0000-0001-6334-9304"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JianCheng Zhong","raw_affiliation_strings":["Hunan Normal University,College of Information Science and Engineering,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Normal University,College of Information Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I173759888","https://openalex.org/I3130607311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.4452975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"879","last_page":"884"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.7653999924659729,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.7653999924659729,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13731","display_name":"Advanced Computing and Algorithms","score":0.7156000137329102,"subfield":{"id":"https://openalex.org/subfields/3322","display_name":"Urban Studies"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6977380514144897},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4516458213329315},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.45146915316581726},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4164971709251404},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.34447360038757324},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.07173937559127808}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6977380514144897},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4516458213329315},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.45146915316581726},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4164971709251404},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.34447360038757324},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.07173937559127808},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10822777","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822777","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320323172","display_name":"Natural Science Foundation of Chongqing","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1971106435","https://openalex.org/W1975147762","https://openalex.org/W2025768430","https://openalex.org/W2137052779","https://openalex.org/W2184981123","https://openalex.org/W2256553158","https://openalex.org/W2592742128","https://openalex.org/W2750900465","https://openalex.org/W2753953057","https://openalex.org/W2770261575","https://openalex.org/W2860192827","https://openalex.org/W2900569176","https://openalex.org/W2902557437","https://openalex.org/W2909637325","https://openalex.org/W2952522777","https://openalex.org/W3004450058","https://openalex.org/W3021338900","https://openalex.org/W3085429933","https://openalex.org/W3126516421","https://openalex.org/W3157315991","https://openalex.org/W3162389729","https://openalex.org/W3175599101","https://openalex.org/W3206585172","https://openalex.org/W4284974145","https://openalex.org/W4378782196","https://openalex.org/W4385330534","https://openalex.org/W4386704360","https://openalex.org/W4391606053"],"related_works":["https://openalex.org/W2731899572","https://openalex.org/W3215138031","https://openalex.org/W2399140686","https://openalex.org/W3009238340","https://openalex.org/W4360585206","https://openalex.org/W4321369474","https://openalex.org/W1980001478","https://openalex.org/W4285208911","https://openalex.org/W3082895349","https://openalex.org/W4213079790"],"abstract_inverted_index":{"Drug-target":[0],"interaction":[1],"(DTI)":[2],"prediction":[3,146],"is":[4],"the":[5,70,73,89,135,148,156],"core":[6],"of":[7,15,76,108,128],"drug":[8,20],"repositioning,":[9],"which":[10,119],"can":[11,120],"promote":[12],"rapid":[13],"screening":[14],"candidate":[16],"drugs":[17,77,129],"and":[18,34,78,83,102,111,130],"shorten":[19],"development":[21],"time.":[22],"Methods":[23],"based":[24],"on":[25,155],"graph":[26,46,85],"neural":[27],"networks":[28],"(GNN)":[29],"have":[30],"attracted":[31],"widespread":[32],"attention":[33],"shown":[35],"certain":[36],"advantages":[37],"in":[38,49],"DTI":[39,145],"prediction.":[40],"However,":[41],"extracting":[42],"deep":[43,64,125],"features":[44,110],"from":[45],"structure":[47],"information":[48,75,86],"heterogeneous":[50],"bioinformatic":[51],"network":[52],"(HBIN)":[53],"still":[54],"faces":[55],"challenges.":[56],"In":[57],"this":[58],"work,":[59],"we":[60,96,133],"propose":[61],"a":[62,115],"novel":[63,116],"self-attention":[65,117],"model":[66,71],"called":[67],"BCHNDTI.":[68],"First,":[69],"integrates":[72],"biological":[74],"targets":[79],"to":[80,105,123,138,169],"construct":[81],"HBIN,":[82],"preprocesses":[84],"by":[87],"using":[88],"path":[90],"integral":[91],"thermonuclear":[92],"(PIHK)":[93],"method.":[94],"Then,":[95],"use":[97,134],"Graph":[98],"Convolutional":[99],"Network":[100],"(GCN)":[101],"Multi-Head":[103],"Attention":[104],"obtain":[106],"representations":[107,127],"HBIN":[109],"input":[112],"them":[113],"into":[114],"network,":[118],"be":[121],"used":[122],"learn":[124],"feature":[126],"targets.":[131],"Finally,":[132],"XGBoost":[136],"classifier":[137],"predict":[139,170],"DTIs.":[140,161],"Compared":[141],"with":[142],"several":[143],"recent":[144],"methods,":[147],"results":[149],"indicated":[150],"that":[151],"BCHNDTI":[152],"performs":[153],"better":[154],"benchmark":[157],"dataset":[158],"for":[159],"identifying":[160],"The":[162],"case":[163],"study":[164],"further":[165],"confirmed":[166],"its":[167],"ability":[168],"potential":[171],"drug-target":[172],"interactions.":[173]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}