{"id":"https://openalex.org/W4406261732","doi":"https://doi.org/10.1109/bibm62325.2024.10822666","title":"REALM: Region-Empowered Antibody Language Model for Antibody Property Prediction","display_name":"REALM: Region-Empowered Antibody Language Model for Antibody Property Prediction","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406261732","doi":"https://doi.org/10.1109/bibm62325.2024.10822666"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10822666","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822666","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050855705","display_name":"Toru Nishino","orcid":null},"institutions":[{"id":"https://openalex.org/I2948482138","display_name":"Fujifilm (Japan)","ror":"https://ror.org/0493bmq37","country_code":"JP","type":"company","lineage":["https://openalex.org/I2948482138"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Nishino","raw_affiliation_strings":["FUJIFILM Corporation,Bio Science & Engineering Laboratories,Tokyo,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FUJIFILM Corporation,Bio Science & Engineering Laboratories,Tokyo,Japan","institution_ids":["https://openalex.org/I2948482138"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Noriji Kato","orcid":null},"institutions":[{"id":"https://openalex.org/I2948482138","display_name":"Fujifilm (Japan)","ror":"https://ror.org/0493bmq37","country_code":"JP","type":"company","lineage":["https://openalex.org/I2948482138"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriji Kato","raw_affiliation_strings":["FUJIFILM Corporation,Bio Science & Engineering Laboratories,Tokyo,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FUJIFILM Corporation,Bio Science & Engineering Laboratories,Tokyo,Japan","institution_ids":["https://openalex.org/I2948482138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053757270","display_name":"Takuya Tsutaoka","orcid":null},"institutions":[{"id":"https://openalex.org/I2948482138","display_name":"Fujifilm (Japan)","ror":"https://ror.org/0493bmq37","country_code":"JP","type":"company","lineage":["https://openalex.org/I2948482138"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Tsutaoka","raw_affiliation_strings":["FUJIFILM Corporation,Bio Science & Engineering Laboratories,Kaisei,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FUJIFILM Corporation,Bio Science & Engineering Laboratories,Kaisei,Japan","institution_ids":["https://openalex.org/I2948482138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011505663","display_name":"Yuanzhong Li","orcid":"https://orcid.org/0000-0003-2490-4867"},"institutions":[{"id":"https://openalex.org/I2948482138","display_name":"Fujifilm (Japan)","ror":"https://ror.org/0493bmq37","country_code":"JP","type":"company","lineage":["https://openalex.org/I2948482138"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuanzhong Li","raw_affiliation_strings":["FUJIFILM Corporation,Bio Science & Engineering Laboratories,Kaisei,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FUJIFILM Corporation,Bio Science & Engineering Laboratories,Kaisei,Japan","institution_ids":["https://openalex.org/I2948482138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061510293","display_name":"Masahito Ohue","orcid":"https://orcid.org/0000-0002-0120-1643"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masahito Ohue","raw_affiliation_strings":["School of Computing Institute of Science Tokyo,Yokohama,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing Institute of Science Tokyo,Yokohama,Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3658,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.68430637,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"7104","last_page":"7106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9811999797821045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/realm","display_name":"Realm","score":0.8090391159057617},{"id":"https://openalex.org/keywords/property","display_name":"Property (philosophy)","score":0.5891340970993042},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5563755631446838},{"id":"https://openalex.org/keywords/history","display_name":"History","score":0.15917730331420898},{"id":"https://openalex.org/keywords/epistemology","display_name":"Epistemology","score":0.12400069832801819},{"id":"https://openalex.org/keywords/philosophy","display_name":"Philosophy","score":0.1131007969379425},{"id":"https://openalex.org/keywords/archaeology","display_name":"Archaeology","score":0.06976956129074097}],"concepts":[{"id":"https://openalex.org/C2778757428","wikidata":"https://www.wikidata.org/wiki/Q1250464","display_name":"Realm","level":2,"score":0.8090391159057617},{"id":"https://openalex.org/C189950617","wikidata":"https://www.wikidata.org/wiki/Q937228","display_name":"Property (philosophy)","level":2,"score":0.5891340970993042},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5563755631446838},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.15917730331420898},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.12400069832801819},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.1131007969379425},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.06976956129074097}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10822666","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822666","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2032515169","https://openalex.org/W2135046866","https://openalex.org/W2949676527","https://openalex.org/W2975542828","https://openalex.org/W3206187363","https://openalex.org/W4249802798","https://openalex.org/W4283068487","https://openalex.org/W4388979610","https://openalex.org/W4399053249","https://openalex.org/W6767440493","https://openalex.org/W6773820404"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2359053655","https://openalex.org/W2387777532","https://openalex.org/W2382709029","https://openalex.org/W2389147080","https://openalex.org/W2377883125","https://openalex.org/W2362479786","https://openalex.org/W2392455911"],"abstract_inverted_index":{"Protein":[0],"language":[1],"models":[2],"(pLM)":[3],"are":[4],"beneficial":[5],"to":[6,18,55],"build":[7],"antibody":[8,20,75],"property":[9],"prediction":[10,48,51],"models.":[11],"However,":[12],"current":[13],"pLMs":[14],"lacks":[15],"the":[16,33,72],"ability":[17],"understand":[19],"properties":[21],"because":[22],"region":[23,50,62],"and":[24,49,79],"structure":[25],"information":[26,63],"is":[27],"not":[28,57],"effectively":[29],"embedded.":[30],"We":[31,66],"propose":[32],"Region-Empowered":[34],"Antibody":[35],"Language":[36],"Model":[37],"(REALM),":[38],"a":[39],"pLM":[40],"built":[41],"by":[42],"multi-task":[43],"pretraining":[44],"strategy":[45],"of":[46,64,74],"residue":[47],"tasks":[52],"in":[53],"antibodies,":[54],"incorporate":[56],"only":[58],"co-evolution":[59],"but":[60],"also":[61],"antibodies.":[65],"demonstrate":[67],"that":[68],"our":[69],"REALM":[70],"improves":[71],"understanding":[73],"properties,":[76],"including":[77],"hydrophobicity":[78],"thermo-stability.":[80]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}