{"id":"https://openalex.org/W4406261917","doi":"https://doi.org/10.1109/bibm62325.2024.10822513","title":"An application of studying FAERS data to Enhance Drug Safety and Treatment Outcomes in Rare Diseases","display_name":"An application of studying FAERS data to Enhance Drug Safety and Treatment Outcomes in Rare Diseases","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406261917","doi":"https://doi.org/10.1109/bibm62325.2024.10822513","pmid":"https://pubmed.ncbi.nlm.nih.gov/40933844"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10822513","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822513","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12419809/pdf/nihms-2109260.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115840543","display_name":"Jaber Valinejad","orcid":null},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaber Valinejad","raw_affiliation_strings":["National Center for Advancing Translational Sciences (NCATS) National Institutes of Health (NIH),Division of Preclinical Innovation,Rockville,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Advancing Translational Sciences (NCATS) National Institutes of Health (NIH),Division of Preclinical Innovation,Rockville,USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004924663","display_name":"Yanji Xu","orcid":"https://orcid.org/0000-0001-8033-3793"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanji Xu","raw_affiliation_strings":["National Center for Advancing Translational Sciences (NCATS) National Institutes of Health (NIH),Division of Rare Diseases Research Innovation,Rockville,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Advancing Translational Sciences (NCATS) National Institutes of Health (NIH),Division of Rare Diseases Research Innovation,Rockville,USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073074181","display_name":"Qian Zhu","orcid":"https://orcid.org/0000-0002-4858-6333"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210148682","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Zhu","raw_affiliation_strings":["National Center for Advancing Translational Sciences (NCATS) National Institutes of Health (NIH),Division of Preclinical Innovation,Rockville,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Advancing Translational Sciences (NCATS) National Institutes of Health (NIH),Division of Preclinical Innovation,Rockville,USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210148682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50679887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2024","issue":null,"first_page":"4575","last_page":"4578"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9768999814987183,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9768999814987183,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9546999931335449,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5160989165306091},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5023460388183594},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3141530752182007},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.16982120275497437}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5160989165306091},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5023460388183594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3141530752182007},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.16982120275497437}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/bibm62325.2024.10822513","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822513","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},{"id":"pmid:40933844","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40933844","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Conference on Bioinformatics and Biomedicine","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12419809","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12419809/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12419809/pdf/nihms-2109260.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings (IEEE Int Conf Bioinformatics Biomed)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:12419809","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12419809/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12419809/pdf/nihms-2109260.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings (IEEE Int Conf Bioinformatics Biomed)","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6499999761581421}],"awards":[{"id":"https://openalex.org/G3458986460","display_name":null,"funder_award_id":"TR000410-05","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G3494643047","display_name":null,"funder_award_id":"Z99 TR999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406261917.pdf","grobid_xml":"https://content.openalex.org/works/W4406261917.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2103675811","https://openalex.org/W2116048670","https://openalex.org/W2277703717","https://openalex.org/W2740576013","https://openalex.org/W2909479143","https://openalex.org/W4207042641","https://openalex.org/W4251391205","https://openalex.org/W4387048849","https://openalex.org/W4392866086","https://openalex.org/W6622621606"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166"],"abstract_inverted_index":{"Rare":[0],"diseases":[1,98],"affect":[2],"fewer":[3],"than":[4],"200,000":[5],"individuals":[6],"in":[7,68,119],"the":[8,26],"United":[9],"States,":[10],"with":[11],"some":[12],"being":[13],"so":[14],"rare":[15,97,120],"that":[16],"only":[17],"a":[18,110],"handful":[19],"of":[20,115],"people":[21],"are":[22,34],"impacted.":[23],"According":[24],"to":[25,64],"U.S.":[27],"Food":[28],"and":[29,81],"Drug":[30],"Administration":[31],"(FDA),":[32],"there":[33],"1,268":[35],"approved":[36],"orphan":[37],"drugs":[38,47],"available":[39],"for":[40,77,96,112],"treating":[41],"these":[42,73,87],"conditions.":[43],"However,":[44],"potentially":[45],"beneficial":[46],"can":[48],"also":[49],"have":[50],"side":[51],"effects.":[52],"Some":[53],"adverse":[54,93],"events,":[55],"while":[56],"serious,":[57],"may":[58],"be":[59],"rare,":[60],"making":[61],"them":[62],"difficult":[63],"identify":[65],"or":[66],"quantify":[67],"randomized":[69],"controlled":[70],"trials.":[71],"Understanding":[72],"events":[74,95],"is":[75],"critical":[76],"improving":[78,116],"patient":[79],"safety":[80,118],"treatment":[82],"outcomes.":[83],"To":[84],"better":[85],"assess":[86],"risks,":[88],"we":[89],"aimed":[90],"at":[91],"summarizing":[92],"drug":[94,117],"by":[99],"utilizing":[100],"FDA":[101],"Adverse":[102],"Event":[103],"Reporting":[104],"System":[105],"(FAERS).":[106],"This":[107],"study":[108],"offers":[109],"foundation":[111],"future":[113],"research":[114],"diseases.":[121]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
