{"id":"https://openalex.org/W4406262025","doi":"https://doi.org/10.1109/bibm62325.2024.10822491","title":"Impact of Extracellular Vesicles Derived from Human Placenta Cells on Neural Progenitor Cell Transcriptome Dynamics","display_name":"Impact of Extracellular Vesicles Derived from Human Placenta Cells on Neural Progenitor Cell Transcriptome Dynamics","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406262025","doi":"https://doi.org/10.1109/bibm62325.2024.10822491"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10822491","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822491","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073582105","display_name":"Pallav Singh","orcid":"https://orcid.org/0000-0002-2720-8288"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pallav Singh","raw_affiliation_strings":["MUIDSI University of Missouri,Columbia,Missouri,USA"],"affiliations":[{"raw_affiliation_string":"MUIDSI University of Missouri,Columbia,Missouri,USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047975034","display_name":"Jessica A. Kinkade","orcid":null},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica A. Kinkade","raw_affiliation_strings":["University of Missouri,Biomedical Sciences,Columbia,Missouri,USA"],"affiliations":[{"raw_affiliation_string":"University of Missouri,Biomedical Sciences,Columbia,Missouri,USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045901208","display_name":"Mohit Verma","orcid":"https://orcid.org/0000-0002-0438-5396"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohit Verma","raw_affiliation_strings":["BBME, University of Missouri,Columbia,Missouri,USA"],"affiliations":[{"raw_affiliation_string":"BBME, University of Missouri,Columbia,Missouri,USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053133545","display_name":"Teka Khan","orcid":"https://orcid.org/0000-0002-2517-5531"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teka Khan","raw_affiliation_strings":["University of Missouri,Animal Sciences,Columbia,Missouri,USA"],"affiliations":[{"raw_affiliation_string":"University of Missouri,Animal Sciences,Columbia,Missouri,USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025054004","display_name":"Toshihiko Ezashi","orcid":"https://orcid.org/0000-0001-6955-8449"},"institutions":[{"id":"https://openalex.org/I4210130646","display_name":"Colorado Center for Reproductive Medicine","ror":"https://ror.org/03v2wv079","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130646"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshihiko Ezashi","raw_affiliation_strings":["Colorado Center for Reproductive Medicine,Lone Tree,Colorado,USA"],"affiliations":[{"raw_affiliation_string":"Colorado Center for Reproductive Medicine,Lone Tree,Colorado,USA","institution_ids":["https://openalex.org/I4210130646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053902032","display_name":"Nathan J. Bivens","orcid":"https://orcid.org/0000-0002-6023-8729"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan J. Bivens","raw_affiliation_strings":["University of Missouri,Genomics Technology Core,Columbia,Missouri,USA"],"affiliations":[{"raw_affiliation_string":"University of Missouri,Genomics Technology Core,Columbia,Missouri,USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024963760","display_name":"R. Michael Roberts","orcid":"https://orcid.org/0000-0002-0008-6559"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Michael Roberts","raw_affiliation_strings":["University of Missouri,Animal Sciences,Columbia,Missouri,USA"],"affiliations":[{"raw_affiliation_string":"University of Missouri,Animal Sciences,Columbia,Missouri,USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090943412","display_name":"Cheryl S. Rosenfeld","orcid":"https://orcid.org/0000-0002-4137-3933"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl S. Rosenfeld","raw_affiliation_strings":["University of Missouri,Biomedical Sciences,Columbia,Missouri,USA"],"affiliations":[{"raw_affiliation_string":"University of Missouri,Biomedical Sciences,Columbia,Missouri,USA","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071079252","display_name":"Trupti Joshi","orcid":"https://orcid.org/0000-0001-8944-4924"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trupti Joshi","raw_affiliation_strings":["BBME, University of Missouri,Columbia,Missouri,USA"],"affiliations":[{"raw_affiliation_string":"BBME, University of Missouri,Columbia,Missouri,USA","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5073582105"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22098296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"457","last_page":"462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9690999984741211,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6504902243614197},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.6008874773979187},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"Extracellular vesicles","score":0.6006631255149841},{"id":"https://openalex.org/keywords/neural-stem-cell","display_name":"Neural stem cell","score":0.5473248958587646},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.5449127554893494},{"id":"https://openalex.org/keywords/extracellular","display_name":"Extracellular","score":0.525107204914093},{"id":"https://openalex.org/keywords/progenitor-cell","display_name":"Progenitor cell","score":0.47188201546669006},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.41705167293548584},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.39996108412742615},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34229326248168945},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.2537696361541748},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.13427600264549255},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11244988441467285},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09994205832481384},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07923537492752075}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6504902243614197},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6008874773979187},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.6006631255149841},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.5473248958587646},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.5449127554893494},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.525107204914093},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.47188201546669006},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41705167293548584},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39996108412742615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34229326248168945},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2537696361541748},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13427600264549255},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11244988441467285},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09994205832481384},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07923537492752075},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10822491","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822491","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320338440","display_name":"HORIZON EUROPE Health","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W2036897871","https://openalex.org/W2041817304","https://openalex.org/W2096173332","https://openalex.org/W2100305481","https://openalex.org/W2102278945","https://openalex.org/W2103912979","https://openalex.org/W2104894587","https://openalex.org/W2108234281","https://openalex.org/W2124985265","https://openalex.org/W2138207763","https://openalex.org/W2159675211","https://openalex.org/W2166820820","https://openalex.org/W2169589032","https://openalex.org/W2174181728","https://openalex.org/W2179438025","https://openalex.org/W2432815617","https://openalex.org/W2791354621","https://openalex.org/W2883778176","https://openalex.org/W2897279578","https://openalex.org/W2899798803","https://openalex.org/W2916759374","https://openalex.org/W2944131287","https://openalex.org/W2946173685","https://openalex.org/W2970358232","https://openalex.org/W2987567173","https://openalex.org/W2987962964","https://openalex.org/W3006778264","https://openalex.org/W3008690186","https://openalex.org/W3011198586","https://openalex.org/W3034047654","https://openalex.org/W3041381454","https://openalex.org/W3130824747","https://openalex.org/W3133859624","https://openalex.org/W3158832078","https://openalex.org/W3165341275","https://openalex.org/W3176897672","https://openalex.org/W3184307727","https://openalex.org/W3202683431","https://openalex.org/W3203475592","https://openalex.org/W3214650490","https://openalex.org/W3215207523","https://openalex.org/W4256503215","https://openalex.org/W4294216483","https://openalex.org/W4308183550","https://openalex.org/W4309908782","https://openalex.org/W4311678495","https://openalex.org/W4387965535","https://openalex.org/W6608852248"],"related_works":["https://openalex.org/W190756422","https://openalex.org/W2399513595","https://openalex.org/W2952941127","https://openalex.org/W4388386498","https://openalex.org/W750390717","https://openalex.org/W1986936937","https://openalex.org/W2125434199","https://openalex.org/W2050711297","https://openalex.org/W2028679378","https://openalex.org/W2024392898"],"abstract_inverted_index":{"The":[0],"fetal":[1,140],"brain":[2],"relies":[3],"on":[4],"the":[5,16,37,40,109,124,127],"placenta":[6,38],"for":[7,148],"essential":[8],"developmental":[9],"signals,":[10],"forming":[11],"what":[12],"is":[13],"known":[14],"as":[15,82,84],"placenta-brain":[17,128],"axis.":[18],"We":[19],"hypothesize":[20],"that":[21,72,132],"extracellular":[22],"vesicles":[23],"(EVs)":[24],"released":[25],"by":[26,101],"trophoblast":[27],"(TB)":[28],"cells":[29,55,66,105],"transport":[30],"small":[31],"RNAs":[32,87],"and":[33,59,80,117,130,145],"other":[34],"molecules":[35],"from":[36,52,60],"to":[39,108],"brain,":[41],"influencing":[42],"its":[43],"early":[44],"development.":[45],"In":[46],"this":[47],"study,":[48],"we":[49],"isolated":[50],"EVs":[51,74,97,134],"human":[53,102],"TB":[54],"differentiated":[56],"in":[57,92,139],"vitro":[58],"their":[61],"parental":[62],"induced":[63],"pluripotent":[64],"stem":[65],"(iPSCs).":[67],"Small":[68],"RNA":[69],"sequencing":[70],"revealed":[71],"TB-derived":[73,96,133],"contain":[75],"distinct":[76],"miRNAs,":[77],"including":[78],"hsa-miR-149-3p":[79],"hsa-miR-302a-5p,":[81],"well":[83],"long":[85],"non-coding":[86],"(lncRNAs),":[88],"which":[89],"are":[90,98],"enriched":[91],"neural":[93,103],"tissue.":[94],"These":[95],"efficiently":[99],"internalized":[100],"progenitor":[104],"(NPCs),":[106],"leading":[107],"induction":[110],"of":[111,126],"transcripts":[112],"associated":[113],"with":[114],"forebrain":[115],"formation":[116],"neurogenesis.":[118],"Our":[119],"findings":[120],"provide":[121],"insights":[122],"into":[123],"role":[125],"axis":[129],"suggest":[131],"may":[135],"be":[136],"key":[137],"players":[138],"neurodevelopment,":[141],"offering":[142],"potential":[143],"biomarkers":[144],"therapeutic":[146],"targets":[147],"neurobehavioral":[149],"disorders":[150,154],"like":[151],"autism":[152],"spectrum":[153],"(ASD).":[155]},"counts_by_year":[],"updated_date":"2025-12-27T23:08:20.325037","created_date":"2025-10-10T00:00:00"}
