{"id":"https://openalex.org/W4406259905","doi":"https://doi.org/10.1109/bibm62325.2024.10822489","title":"A Graph Embedded Feature Decoupling Model for Clustering Single Cell RNA-seq Data","display_name":"A Graph Embedded Feature Decoupling Model for Clustering Single Cell RNA-seq Data","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406259905","doi":"https://doi.org/10.1109/bibm62325.2024.10822489"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10822489","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822489","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048433371","display_name":"Xiaoming Yan","orcid":"https://orcid.org/0000-0002-5263-9952"},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoming Yan","raw_affiliation_strings":["National University of Defense Technology,College of Computer Science and Technology,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Defense Technology,College of Computer Science and Technology,Changsha,China","institution_ids":["https://openalex.org/I170215575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101897932","display_name":"Liyang Xu","orcid":"https://orcid.org/0000-0003-0932-643X"},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyang Xu","raw_affiliation_strings":["National University of Defense Technology,College of Computer Science and Technology,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Defense Technology,College of Computer Science and Technology,Changsha,China","institution_ids":["https://openalex.org/I170215575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048925843","display_name":"Haoang Chi","orcid":"https://orcid.org/0000-0002-2644-3323"},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoang Chi","raw_affiliation_strings":["National University of Defense Technology,College of Computer Science and Technology,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Defense Technology,College of Computer Science and Technology,Changsha,China","institution_ids":["https://openalex.org/I170215575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100763888","display_name":"Huihui Yang","orcid":"https://orcid.org/0000-0002-1253-5251"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huihui Yang","raw_affiliation_strings":["School of Life Science Central South University,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science Central South University,Changsha,China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444099","display_name":"Huan Chen","orcid":"https://orcid.org/0000-0001-6449-4116"},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Chen","raw_affiliation_strings":["National University of Defense Technology,College of Computer Science and Technology,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Defense Technology,College of Computer Science and Technology,Changsha,China","institution_ids":["https://openalex.org/I170215575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065371644","display_name":"Yuhua Tang","orcid":"https://orcid.org/0000-0002-4956-3379"},"institutions":[{"id":"https://openalex.org/I170215575","display_name":"National University of Defense Technology","ror":"https://ror.org/05d2yfz11","country_code":"CN","type":"education","lineage":["https://openalex.org/I170215575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhua Tang","raw_affiliation_strings":["National University of Defense Technology,College of Computer Science and Technology,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National University of Defense Technology,College of Computer Science and Technology,Changsha,China","institution_ids":["https://openalex.org/I170215575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20683814,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1720","last_page":"1725"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9397000074386597,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6740219593048096},{"id":"https://openalex.org/keywords/decoupling","display_name":"Decoupling (probability)","score":0.6211785078048706},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6076640486717224},{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-Seq","score":0.49668723344802856},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4699670970439911},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4493020176887512},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4417978823184967},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.4346126914024353},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3491252064704895},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.23973414301872253},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09146147966384888},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.07007837295532227}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6740219593048096},{"id":"https://openalex.org/C205606062","wikidata":"https://www.wikidata.org/wiki/Q5249645","display_name":"Decoupling (probability)","level":2,"score":0.6211785078048706},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6076640486717224},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.49668723344802856},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4699670970439911},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4493020176887512},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4417978823184967},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.4346126914024353},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3491252064704895},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.23973414301872253},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09146147966384888},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07007837295532227},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.0},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10822489","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822489","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W2069089843","https://openalex.org/W2133811295","https://openalex.org/W2800392236","https://openalex.org/W2907783748","https://openalex.org/W2951381561","https://openalex.org/W2951506174","https://openalex.org/W2998272743","https://openalex.org/W3084428275","https://openalex.org/W3127011314","https://openalex.org/W3137285774","https://openalex.org/W3163972593","https://openalex.org/W4283815719","https://openalex.org/W4294051824","https://openalex.org/W4297977428","https://openalex.org/W4315621823","https://openalex.org/W4317888741","https://openalex.org/W4382318104","https://openalex.org/W6718140377","https://openalex.org/W6745316256","https://openalex.org/W6791742336"],"related_works":["https://openalex.org/W4313561376","https://openalex.org/W3103825105","https://openalex.org/W3027880158","https://openalex.org/W3207533102","https://openalex.org/W1617565119","https://openalex.org/W160381218","https://openalex.org/W2512958550","https://openalex.org/W2004102934","https://openalex.org/W4366455350","https://openalex.org/W2329266651"],"abstract_inverted_index":{"The":[0,34],"rapid":[1],"development":[2],"in":[3,31,71,148],"single-cell":[4],"RNA":[5],"sequencing":[6],"(scRNA-seq)":[7],"has":[8,39],"dramatically":[9],"enhanced":[10],"our":[11],"insight":[12],"into":[13],"cellular":[14,110],"heterogeneity":[15],"and":[16,53,152,171],"disease":[17],"mechanisms.":[18],"In":[19,117],"the":[20,41,50,74,91,105,118,129,149],"analysis":[21,42],"of":[22,36,55,65],"scRNA-seq":[23,56,176],"data,":[24,57],"cell":[25,45,83,102],"clustering":[26,162],"plays":[27],"a":[28,63,98,123],"vital":[29],"role":[30],"downstream":[32],"tasks.":[33],"advent":[35],"deep":[37],"learning":[38],"revolutionized":[40],"method":[43,126],"for":[44,101],"clustering.":[46,103],"However,":[47],"due":[48],"to":[49,81],"high":[51],"dimensionality":[52],"sparsity":[54],"neural":[58,115],"network-based":[59],"methods":[60,163],"often":[61],"capture":[62,109],"multitude":[64],"spurious":[66],"correlations.":[67],"This":[68],"oversight":[69],"results":[70],"redundancy":[72,147],"within":[73],"low-dimensional":[75],"feature":[76,124,135],"space,":[77],"making":[78],"it":[79],"difficult":[80],"distinguish":[82],"subpopulations.":[84],"To":[85],"address":[86],"these":[87],"limitations,":[88],"we":[89,108,121,133],"introduce":[90],"Graph":[92],"Embedded":[93],"Feature":[94],"Decoupling":[95],"model":[96],"(scGEFD),":[97],"two-phase":[99],"approach":[100],"During":[104],"first":[106],"phase,":[107,120],"structural":[111],"information":[112],"by":[113,128,137],"graph":[114],"network.":[116],"second":[119],"propose":[122],"decoupling":[125],"inspired":[127],"Barlow":[130],"Twins.":[131],"Specifically,":[132],"refine":[134],"representations":[136],"minimizing":[138],"discrepancies":[139],"between":[140],"two":[141],"perturbed":[142],"sample":[143],"versions,":[144],"which":[145],"reduces":[146],"latent":[150],"space":[151],"further":[153],"accentuates":[154],"biologically":[155],"pertinent":[156],"features.":[157],"Consequently,":[158],"scGEFD":[159],"outperforms":[160],"state-of-the-art":[161],"on":[164],"ten":[165],"real-world":[166],"datasets,":[167],"providing":[168],"more":[169],"accurate":[170],"meaningful":[172],"biological":[173],"insights":[174],"from":[175],"data.":[177]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}