{"id":"https://openalex.org/W4406271342","doi":"https://doi.org/10.1109/bibm62325.2024.10822378","title":"Unintended Risks of mRNA COVID-19 Vaccines: A UISS Simulation Study on Immune and Organ Health","display_name":"Unintended Risks of mRNA COVID-19 Vaccines: A UISS Simulation Study on Immune and Organ Health","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406271342","doi":"https://doi.org/10.1109/bibm62325.2024.10822378"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10822378","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822378","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083311782","display_name":"Valentina Di Salvatore","orcid":"https://orcid.org/0000-0001-5576-3070"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Di Salvatore","raw_affiliation_strings":["University of Catania,Department of Health and Drug Sciences,Catania,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Catania,Department of Health and Drug Sciences,Catania,Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004880055","display_name":"Giulia Russo","orcid":"https://orcid.org/0000-0001-6616-7856"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Russo","raw_affiliation_strings":["University of Catania,Department of Health and Drug Sciences,Catania,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Catania,Department of Health and Drug Sciences,Catania,Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044340074","display_name":"Francesco Pappalardo","orcid":"https://orcid.org/0000-0003-1668-3320"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Pappalardo","raw_affiliation_strings":["University of Catania,Department of Health and Drug Sciences,Catania,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Catania,Department of Health and Drug Sciences,Catania,Italy","institution_ids":["https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I39063666"],"apc_list":null,"apc_paid":null,"fwci":6.0529,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.96412948,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"6661","last_page":"6666"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.5845999717712402,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.5845999717712402,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.718544602394104},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6553323268890381},{"id":"https://openalex.org/keywords/unintended-consequences","display_name":"Unintended consequences","score":0.566776692867279},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.47442927956581116},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.47296661138534546},{"id":"https://openalex.org/keywords/2019-20-coronavirus-outbreak","display_name":"2019-20 coronavirus outbreak","score":0.44072476029396057},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.37902143597602844},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3501615822315216},{"id":"https://openalex.org/keywords/outbreak","display_name":"Outbreak","score":0.12713190913200378},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.10433810949325562},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.09406420588493347},{"id":"https://openalex.org/keywords/political-science","display_name":"Political science","score":0.09131067991256714}],"concepts":[{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.718544602394104},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6553323268890381},{"id":"https://openalex.org/C2776889888","wikidata":"https://www.wikidata.org/wiki/Q1135789","display_name":"Unintended consequences","level":2,"score":0.566776692867279},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.47442927956581116},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.47296661138534546},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.44072476029396057},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37902143597602844},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3501615822315216},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.12713190913200378},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.10433810949325562},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09406420588493347},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.09131067991256714},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10822378","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822378","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W3193427089","https://openalex.org/W3202367516","https://openalex.org/W3207747730","https://openalex.org/W4220735153","https://openalex.org/W4313244177","https://openalex.org/W4319601292","https://openalex.org/W4322217266","https://openalex.org/W4327726434","https://openalex.org/W4379376213","https://openalex.org/W4399651506","https://openalex.org/W6783286666"],"related_works":["https://openalex.org/W3036314732","https://openalex.org/W3009669391","https://openalex.org/W3176864053","https://openalex.org/W4206669628","https://openalex.org/W3171943759","https://openalex.org/W4292098121","https://openalex.org/W3154141118","https://openalex.org/W4388896133","https://openalex.org/W3031607536","https://openalex.org/W3198183218"],"abstract_inverted_index":{"In":[0,86],"2019,":[1],"humanity":[2],"witnessed":[3],"one":[4,55],"of":[5,24,30,42,56,60,74,107,122,128,142],"the":[6,20,28,57,61,94,104,120,132,143],"most":[7,95],"violent":[8],"and":[9,27,44,78,124],"dangerous":[10],"pandemics":[11],"ever":[12],"seen:":[13],"SARS-CoV-2":[14,54],"emerged":[15],"suddenly,":[16],"spreading":[17],"rapidly":[18],"across":[19],"world.":[21],"The":[22],"speed":[23],"its":[25,31,76,80],"spread":[26,77],"severity":[29],"infections\u2014with":[32],"clinical":[33],"symptoms":[34],"ranging":[35],"from":[36],"flu-like":[37],"manifestations":[38],"to":[39,48],"various":[40],"forms":[41],"pneumonia,":[43],"even":[45,102],"death":[46],"due":[47],"acute":[49],"respiratory":[50],"distress":[51],"syndrome":[52],"(ARDS)\u2014made":[53],"deadliest":[58],"members":[59],"coronavirus":[62],"family.":[63],"This":[64],"triggered":[65],"an":[66],"urgent,":[67],"global":[68],"search":[69],"for":[70,98,138],"new":[71],"technologies":[72],"capable":[73],"curbing":[75],"mitigating":[79],"effects":[81,106,127],"as":[82,84,93],"quickly":[83],"possible.":[85],"this":[87,109],"context,":[88],"mRNA":[89,129],"vaccines":[90,112],"established":[91],"themselves":[92],"promising":[96],"solution":[97],"a":[99],"rapid":[100],"response,":[101],"though":[103],"long-term":[105],"using":[108,131],"technology":[110],"in":[111,139],"remained":[113],"unclear.":[114],"Here,":[115],"we":[116],"shed":[117],"light":[118],"on":[119],"mechanism":[121],"action":[123],"potential":[125],"side":[126],"vaccines,":[130],"Universal":[133],"Immune":[134],"System":[135],"Simulator":[136],"(UISS)":[137],"silico":[140],"simulation":[141],"human":[144],"immune":[145],"response.":[146]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}