{"id":"https://openalex.org/W4406260252","doi":"https://doi.org/10.1109/bibm62325.2024.10822324","title":"ResPocket: A Multi-Scale Feature Fusion Method for Improving Protein Binding Site Detection","display_name":"ResPocket: A Multi-Scale Feature Fusion Method for Improving Protein Binding Site Detection","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406260252","doi":"https://doi.org/10.1109/bibm62325.2024.10822324"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10822324","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822324","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100450516","display_name":"Xiaoli Lin","orcid":"https://orcid.org/0000-0002-5595-4966"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoli Lin","raw_affiliation_strings":["Wuhan University of Science and Technology,Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology,China"],"affiliations":[{"raw_affiliation_string":"Wuhan University of Science and Technology,Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology,China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101974334","display_name":"Wenli Yang","orcid":"https://orcid.org/0000-0003-1400-083X"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenli Yang","raw_affiliation_strings":["Wuhan University of Science and Technology,Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology,China"],"affiliations":[{"raw_affiliation_string":"Wuhan University of Science and Technology,Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology,China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101695631","display_name":"Yaoyu Chen","orcid":"https://orcid.org/0000-0002-1245-1146"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaoyu Chen","raw_affiliation_strings":["Wuhan University of Science and Technology,Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology,China"],"affiliations":[{"raw_affiliation_string":"Wuhan University of Science and Technology,Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology,China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109983685","display_name":"Xueying Liao","orcid":"https://orcid.org/0009-0002-2039-4783"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiongwei Liao","raw_affiliation_strings":["Wuhan University of Science and Technology,Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology,China"],"affiliations":[{"raw_affiliation_string":"Wuhan University of Science and Technology,Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology,China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006822077","display_name":"Zimo Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zimo Wu","raw_affiliation_strings":["Wuhan University of Science and Technology,Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology,China"],"affiliations":[{"raw_affiliation_string":"Wuhan University of Science and Technology,Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology,China","institution_ids":["https://openalex.org/I43922553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100395706","display_name":"Xiaolong Zhang","orcid":"https://orcid.org/0000-0003-2498-9370"},"institutions":[{"id":"https://openalex.org/I43922553","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88","country_code":"CN","type":"education","lineage":["https://openalex.org/I43922553"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolong Zhang","raw_affiliation_strings":["Wuhan University of Science and Technology,Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology,China"],"affiliations":[{"raw_affiliation_string":"Wuhan University of Science and Technology,Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology,China","institution_ids":["https://openalex.org/I43922553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100450516"],"corresponding_institution_ids":["https://openalex.org/I43922553"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22065159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1588","last_page":"1591"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9426000118255615,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9157999753952026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6238614916801453},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.5332047343254089},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4965575337409973},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4592798054218292},{"id":"https://openalex.org/keywords/fusion","display_name":"Fusion","score":0.45448067784309387},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.44571730494499207},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.36322107911109924},{"id":"https://openalex.org/keywords/geography","display_name":"Geography","score":0.05574452877044678}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6238614916801453},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.5332047343254089},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4965575337409973},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4592798054218292},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.45448067784309387},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.44571730494499207},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.36322107911109924},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.05574452877044678},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10822324","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822324","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325431","display_name":"Wuhan University of Science and Technology","ror":"https://ror.org/00e4hrk88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W1980969309","https://openalex.org/W1993046136","https://openalex.org/W2763936395","https://openalex.org/W2887981960","https://openalex.org/W3006477052","https://openalex.org/W3007743886","https://openalex.org/W3012511738","https://openalex.org/W3165603781","https://openalex.org/W4210721499","https://openalex.org/W4313525416","https://openalex.org/W4318542832","https://openalex.org/W4364351976","https://openalex.org/W4367669413","https://openalex.org/W4385767830"],"related_works":["https://openalex.org/W3147584709","https://openalex.org/W2099421762","https://openalex.org/W2530546662","https://openalex.org/W2967030268","https://openalex.org/W2977677679","https://openalex.org/W2185253430","https://openalex.org/W1992327129","https://openalex.org/W4210345652","https://openalex.org/W2381986121","https://openalex.org/W2370918718"],"abstract_inverted_index":{"Accurate":[0],"detection":[1],"of":[2,26,48,109,130,138],"protein":[3,98],"binding":[4],"sites":[5],"is":[6,57,77],"critical":[7],"for":[8],"facilitating":[9],"drug":[10],"design.":[11],"Most":[12],"existing":[13],"models":[14],"rely":[15],"on":[16,55,93,117,132,142],"features":[17,47,61],"at":[18],"a":[19,37],"single":[20],"scale,":[21],"leading":[22],"to":[23,42,59,79,105],"the":[24,45,107,110],"loss":[25],"crucial":[27],"global":[28,66,86],"or":[29],"local":[30,68,95],"structural":[31,69],"information.":[32,70,88],"Therefore,":[33],"this":[34],"paper":[35],"proposes":[36],"novel":[38],"3D":[39],"model":[40,112],"(ResPocket),":[41],"fully":[43],"capture":[44,60],"multi-scale":[46],"proteins.":[49],"First,":[50],"Residual":[51],"Block":[52,103],"(ResB)":[53],"based":[54],"U-Net":[56],"used":[58],"from":[62],"different":[63],"scales,":[64],"including":[65],"and":[67,113,140,144],"Then,":[71],"an":[72,128,136],"Enhanced":[73],"Attention":[74],"Module":[75],"(EAM)":[76],"designed":[78],"encode":[80],"semantic":[81],"dependencies":[82],"by":[83,127,135],"effectively":[84],"capturing":[85],"context":[87],"In":[89],"addition,":[90],"ResPocket":[91,125],"focuses":[92],"learning":[94],"information":[96],"about":[97],"pockets":[99],"with":[100],"Self-Guided":[101],"Mask":[102],"(SGMB),":[104],"increase":[106],"robustness":[108],"overall":[111],"reduce":[114],"its":[115],"dependence":[116],"external":[118],"mask":[119],"guidance.":[120],"Experimental":[121],"results":[122],"show":[123],"that":[124],"improves":[126],"average":[129,137],"4.89%":[131],"DCA":[133],"Top-n,":[134],"1.48%":[139],"2.25%":[141],"DCC":[143],"DVO":[145],"metrics,":[146],"respectively.":[147]},"counts_by_year":[],"updated_date":"2025-12-21T23:12:01.093139","created_date":"2025-10-10T00:00:00"}