{"id":"https://openalex.org/W4406262165","doi":"https://doi.org/10.1109/bibm62325.2024.10822267","title":"Dual-Stream Heterogeneous Graph Neural Network Based on Zero-Shot Embeddings for Predicting miRNA-Drug Sensitivity","display_name":"Dual-Stream Heterogeneous Graph Neural Network Based on Zero-Shot Embeddings for Predicting miRNA-Drug Sensitivity","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406262165","doi":"https://doi.org/10.1109/bibm62325.2024.10822267"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10822267","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822267","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100432712","display_name":"Peng Li","orcid":"https://orcid.org/0000-0002-5078-5091"},"institutions":[{"id":"https://openalex.org/I121296143","display_name":"Hunan University of Science and Technology","ror":"https://ror.org/02m9vrb24","country_code":"CN","type":"education","lineage":["https://openalex.org/I121296143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Peng","raw_affiliation_strings":["Hunan University of Science and Technology,College of Computer Science and Engineering,Xiangtan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Science and Technology,College of Computer Science and Engineering,Xiangtan,China","institution_ids":["https://openalex.org/I121296143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103581056","display_name":"Wang Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I121296143","display_name":"Hunan University of Science and Technology","ror":"https://ror.org/02m9vrb24","country_code":"CN","type":"education","lineage":["https://openalex.org/I121296143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang Wang","raw_affiliation_strings":["Hunan University of Science and Technology,College of Computer Science and Engineering,Xiangtan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Science and Technology,College of Computer Science and Engineering,Xiangtan,China","institution_ids":["https://openalex.org/I121296143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103885079","display_name":"Cheng Yang","orcid":"https://orcid.org/0000-0002-3144-7329"},"institutions":[{"id":"https://openalex.org/I121296143","display_name":"Hunan University of Science and Technology","ror":"https://ror.org/02m9vrb24","country_code":"CN","type":"education","lineage":["https://openalex.org/I121296143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Yang","raw_affiliation_strings":["Hunan University of Science and Technology,College of Computer Science and Engineering,Xiangtan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Science and Technology,College of Computer Science and Engineering,Xiangtan,China","institution_ids":["https://openalex.org/I121296143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101154529","display_name":"Wenhui Xiao","orcid":null},"institutions":[{"id":"https://openalex.org/I121296143","display_name":"Hunan University of Science and Technology","ror":"https://ror.org/02m9vrb24","country_code":"CN","type":"education","lineage":["https://openalex.org/I121296143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhui Xiao","raw_affiliation_strings":["Hunan University of Science and Technology,College of Computer Science and Engineering,Xiangtan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan University of Science and Technology,College of Computer Science and Engineering,Xiangtan,China","institution_ids":["https://openalex.org/I121296143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044283271","display_name":"Xiangzheng Fu","orcid":"https://orcid.org/0000-0001-6840-2573"},"institutions":[{"id":"https://openalex.org/I141568987","display_name":"Hong Kong Baptist University","ror":"https://ror.org/0145fw131","country_code":"HK","type":"education","lineage":["https://openalex.org/I141568987"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Xiangzheng Fu","raw_affiliation_strings":["Hong Kong Baptist University,College of Chinese Medicine,Hong Kong,SAR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hong Kong Baptist University,College of Chinese Medicine,Hong Kong,SAR China","institution_ids":["https://openalex.org/I141568987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100405157","display_name":"Yifan Chen","orcid":"https://orcid.org/0000-0003-4880-3489"},"institutions":[{"id":"https://openalex.org/I119273862","display_name":"Central South University of Forestry and Technology","ror":"https://ror.org/02czw2k81","country_code":"CN","type":"education","lineage":["https://openalex.org/I119273862"]},{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Chen","raw_affiliation_strings":["Central South University of Forestry and Technology,College of Computer and Information Engineering,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central South University of Forestry and Technology,College of Computer and Information Engineering,Changsha,China","institution_ids":["https://openalex.org/I119273862","https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1122","last_page":"1128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9890000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9850000143051147,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.6238917112350464},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6215682625770569},{"id":"https://openalex.org/keywords/dual","display_name":"Dual (grammatical number)","score":0.5690413117408752},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.5077387094497681},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.49256640672683716},{"id":"https://openalex.org/keywords/zero","display_name":"Zero (linguistics)","score":0.4325546622276306},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.37348634004592896},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.21015429496765137},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.06496289372444153}],"concepts":[{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.6238917112350464},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6215682625770569},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.5690413117408752},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5077387094497681},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.49256640672683716},{"id":"https://openalex.org/C2780813799","wikidata":"https://www.wikidata.org/wiki/Q3274237","display_name":"Zero (linguistics)","level":2,"score":0.4325546622276306},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37348634004592896},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.21015429496765137},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.06496289372444153},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10822267","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822267","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W2059994125","https://openalex.org/W2106210472","https://openalex.org/W2137403619","https://openalex.org/W2747907311","https://openalex.org/W2800753891","https://openalex.org/W2803908182","https://openalex.org/W2919918774","https://openalex.org/W2977216863","https://openalex.org/W3036062177","https://openalex.org/W3093030756","https://openalex.org/W3113654230","https://openalex.org/W3131891239","https://openalex.org/W4206547282","https://openalex.org/W4210466552","https://openalex.org/W4226097900","https://openalex.org/W4298001693","https://openalex.org/W4308372707","https://openalex.org/W4309098239","https://openalex.org/W4309645563","https://openalex.org/W4313245211","https://openalex.org/W4360770766","https://openalex.org/W4381046896","https://openalex.org/W4383711298","https://openalex.org/W4386892950","https://openalex.org/W4387623731","https://openalex.org/W4388481037","https://openalex.org/W4389481640","https://openalex.org/W4389903759","https://openalex.org/W4398151435","https://openalex.org/W4398784522","https://openalex.org/W4399556056","https://openalex.org/W4401070379","https://openalex.org/W6846096296"],"related_works":["https://openalex.org/W2378757965","https://openalex.org/W3013650182","https://openalex.org/W2989283631","https://openalex.org/W4249605382","https://openalex.org/W4313491656","https://openalex.org/W4224903346","https://openalex.org/W3279617","https://openalex.org/W4402958497","https://openalex.org/W1593262897","https://openalex.org/W2958550830"],"abstract_inverted_index":{"MicroRNAs":[0],"(miRNAs)":[1],"are":[2,143],"a":[3,60,147],"class":[4],"of":[5,20,33,124,134,180],"non-coding":[6],"RNA":[7],"molecules":[8],"that":[9,191],"have":[10],"been":[11],"shown":[12],"to":[13,42,46,72,129,152,175],"be":[14],"closely":[15],"associated":[16],"with":[17,88],"the":[18,27,48,74,110,119,125,154,164,177,181],"sensitivity":[19,49,76,155,200],"chemotherapeutic":[21],"drugs":[22],"in":[23,146],"cancer":[24],"treatment.":[25],"Given":[26],"high":[28],"cost":[29],"and":[30,53,80,102,136,160,204],"extended":[31],"duration":[32],"traditional":[34],"biological":[35],"experiments,":[36],"there":[37],"is":[38,193],"an":[39,194],"urgent":[40],"need":[41],"develop":[43],"computational":[44],"models":[45,100],"predict":[47],"scores":[50,77,157,201],"between":[51,78,158,202],"miRNAs":[52,79,135,159,203],"drugs.":[54,81,137,161,205],"In":[55],"this":[56],"study,":[57],"we":[58,172],"proposed":[59],"dual-stream":[61],"graph":[62],"neural":[63],"network":[64],"method":[65],"based":[66,92],"on":[67,93,168],"Zero-Shot":[68],"Embeddings,":[69],"named":[70],"DSHGZS,":[71],"explore":[73],"potential":[75,199],"DSHGZS":[82,192],"first":[83],"constructs":[84],"two":[85,126],"heterogeneous":[86,127],"graphs":[87,128],"different":[89],"isomorphic":[90],"subgraphs":[91],"zero-shot":[94],"embeddings":[95,142],"obtained":[96],"from":[97],"large":[98],"language":[99],"(LLMs)":[101],"known":[103],"miRNA-drug":[104],"association":[105,156],"data.":[106],"It":[107],"then":[108],"utilized":[109],"enhanced":[111],"LLM-derived":[112,182],"node":[113,183],"feature":[114,121,141,170],"representations,":[115,171],"embedding":[116],"them":[117],"into":[118],"layer":[120],"learning":[122],"process":[123],"generate":[130],"high-quality":[131,140,169],"vector":[132],"representations":[133,179],"The":[138],"learned":[139],"subsequently":[144],"used":[145],"segmented":[148],"inner":[149],"product":[150],"decoder":[151],"evaluate":[153],"To":[162],"address":[163],"model\u2019s":[165],"excessive":[166],"reliance":[167],"employed":[173],"PCA":[174],"extract":[176],"core":[178],"features":[184],"for":[185,197],"data":[186],"augmentation.":[187],"Case":[188],"studies":[189],"demonstrated":[190],"effective":[195],"tool":[196],"predicting":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}