{"id":"https://openalex.org/W4406238243","doi":"https://doi.org/10.1109/bibm62325.2024.10822231","title":"Muli-Task Dual-view Model for Drug Combination Analysis: In Vivo and In Vitro Perspectives","display_name":"Muli-Task Dual-view Model for Drug Combination Analysis: In Vivo and In Vitro Perspectives","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406238243","doi":"https://doi.org/10.1109/bibm62325.2024.10822231"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10822231","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822231","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009881224","display_name":"Yuhe Yang","orcid":"https://orcid.org/0000-0003-0719-4867"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhe Yang","raw_affiliation_strings":["University of Electronic Science and Technology of China,School of Life Science and Technology,Chengdu,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China,School of Life Science and Technology,Chengdu,China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073409235","display_name":"Zhao\u2010Yue Zhang","orcid":"https://orcid.org/0000-0002-4619-247X"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaoyue Zhang","raw_affiliation_strings":["University of Electronic Science and Technology of China,School of Medicine,Chengdu,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China,School of Medicine,Chengdu,China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100936108","display_name":"Xueqin Xie","orcid":null},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueqin Xie","raw_affiliation_strings":["University of Electronic Science and Technology of China,School of Life Science and Technology,Chengdu,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China,School of Life Science and Technology,Chengdu,China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051695999","display_name":"Wei Su","orcid":"https://orcid.org/0000-0001-6818-0149"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Su","raw_affiliation_strings":["University of Electronic Science and Technology of China,School of Life Science and Technology,Chengdu,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China,School of Life Science and Technology,Chengdu,China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021812514","display_name":"Kejun Deng","orcid":"https://orcid.org/0000-0003-0411-549X"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kejun Deng","raw_affiliation_strings":["University of Electronic Science and Technology of China,School of Life Science and Technology,Chengdu,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China,School of Life Science and Technology,Chengdu,China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041539298","display_name":"Hao Lin","orcid":"https://orcid.org/0000-0001-6265-2862"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Lin","raw_affiliation_strings":["University of Electronic Science and Technology of China,School of Life Science and Technology,Chengdu,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China,School of Life Science and Technology,Chengdu,China","institution_ids":["https://openalex.org/I150229711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150229711"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"791","last_page":"796"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.982699990272522,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.982699990272522,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6263540983200073},{"id":"https://openalex.org/keywords/dual","display_name":"Dual (grammatical number)","score":0.6079152822494507},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.568975567817688},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.45932289958000183},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.4473445415496826},{"id":"https://openalex.org/keywords/systems-engineering","display_name":"Systems engineering","score":0.16533604264259338},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1500658094882965},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1423756182193756},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12404978275299072},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.0732676088809967},{"id":"https://openalex.org/keywords/art","display_name":"Art","score":0.062221378087997437}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6263540983200073},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.6079152822494507},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.568975567817688},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.45932289958000183},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4473445415496826},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.16533604264259338},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1500658094882965},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1423756182193756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12404978275299072},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0732676088809967},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.062221378087997437},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10822231","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822231","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1975147762","https://openalex.org/W1988037271","https://openalex.org/W2045916299","https://openalex.org/W2195203261","https://openalex.org/W2767891136","https://openalex.org/W2903936751","https://openalex.org/W2911310649","https://openalex.org/W2912247484","https://openalex.org/W3116202926","https://openalex.org/W4214868967","https://openalex.org/W4288712766","https://openalex.org/W4308834336","https://openalex.org/W4327564965","https://openalex.org/W4385245566","https://openalex.org/W4385567824","https://openalex.org/W4387663038","https://openalex.org/W4389937842","https://openalex.org/W4390114353","https://openalex.org/W4390193806","https://openalex.org/W4391737993","https://openalex.org/W4400396982","https://openalex.org/W4400519477","https://openalex.org/W6752178629","https://openalex.org/W6754929296","https://openalex.org/W6766673545","https://openalex.org/W6780017182","https://openalex.org/W6843615466"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2157355069","https://openalex.org/W2069460318","https://openalex.org/W2333960626","https://openalex.org/W2021792849","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433"],"abstract_inverted_index":{"Drug-drug":[0],"interactions":[1,6,153],"(DDIs)":[2],"and":[3,20,57,67,90,97,106,114,135,162],"drug":[4,13,37,83,152],"compatibility":[5],"(DCIs)":[7],"are":[8],"both":[9],"critical":[10],"components":[11],"of":[12,69,130,150],"combination":[14,38,84],"(DC),":[15],"essential":[16],"for":[17,82,132,137],"ensuring":[18],"safe":[19],"effective":[21],"therapeutic":[22,164],"strategies.":[23],"DDIs":[24,45,89],"typically":[25],"occur":[26,31],"in":[27,32,55,58,117,154],"vivo,":[28],"while":[29],"DCIs":[30,91],"vitro.":[33],"However,":[34],"most":[35],"existing":[36],"prediction":[39],"models":[40,104],"focus":[41],"solely":[42],"on":[43,140],"either":[44],"or":[46],"DCIs,":[47],"lacking":[48],"a":[49,78,118,146],"comprehensive":[50,148],"approach":[51,123],"to":[52,64,108],"predict":[53],"DC":[54,70],"vivo":[56],"vitro":[59],"perspectives,":[60],"which":[61],"can":[62],"lead":[63],"incomplete":[65],"understanding":[66,149],"management":[68],"risks.":[71],"To":[72],"address":[73],"this":[74],"problem,":[75],"we":[76],"propose":[77],"multi-task":[79,119],"dual-view":[80],"model":[81],"(MDDC)":[85],"that":[86],"simultaneously":[87],"predicts":[88],"by":[92],"using":[93],"pre-trained":[94],"molecular":[95,112],"sequence":[96],"graph":[98],"representations.":[99],"MDDC":[100,144],"utilized":[101],"the":[102],"pretrained":[103],"ChemBERTa-2":[105],"MolCLR":[107],"capture":[109],"diverse":[110],"view":[111],"features":[113],"fine-tune":[115],"them":[116],"learning":[120],"framework.":[121],"This":[122],"demonstrated":[124],"notable":[125],"performance":[126],"improvements,":[127],"with":[128],"AUROCs":[129],"0.914":[131],"DDI":[133],"task,":[134],"0.826":[136],"DCI":[138],"tasks":[139],"independent":[141],"testing":[142],"dataset.":[143],"offers":[145],"more":[147],"potential":[151],"medication":[155],"guidance,":[156],"thereby":[157],"reducing":[158],"adverse":[159],"effect":[160],"risks":[161],"enhancing":[163],"safety.":[165]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}