{"id":"https://openalex.org/W4406238241","doi":"https://doi.org/10.1109/bibm62325.2024.10822214","title":"Machine Learning Models Highlight the Impact of Pollution and Weather Patterns on Relapse Occurrence in Multiple Sclerosis Patients","display_name":"Machine Learning Models Highlight the Impact of Pollution and Weather Patterns on Relapse Occurrence in Multiple Sclerosis Patients","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406238241","doi":"https://doi.org/10.1109/bibm62325.2024.10822214"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10822214","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822214","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114316569","display_name":"Elena Marinello","orcid":null},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Marinello","raw_affiliation_strings":["University of Padova,Department of Information Engineering,Padova,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Padova,Department of Information Engineering,Padova,Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039343044","display_name":"Erica Tavazzi","orcid":"https://orcid.org/0000-0001-6188-6413"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Erica Tavazzi","raw_affiliation_strings":["Multiple Sclerosis Centre IRCCS Mondino Foundation,Pavia,Italy","University of Padova,Department of Information Engineering,Padova,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multiple Sclerosis Centre IRCCS Mondino Foundation,Pavia,Italy","institution_ids":[]},{"raw_affiliation_string":"University of Padova,Department of Information Engineering,Padova,Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013911767","display_name":"Enrico Longato","orcid":"https://orcid.org/0000-0001-5940-645X"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Longato","raw_affiliation_strings":["University of Padova,Department of Information Engineering,Padova,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Padova,Department of Information Engineering,Padova,Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061571103","display_name":"Pietro Bosoni","orcid":"https://orcid.org/0000-0002-1431-6044"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pietro Bosoni","raw_affiliation_strings":["University of Pavia,Department of Industrial and Information Engineering,Pavia,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia,Department of Industrial and Information Engineering,Pavia,Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068449833","display_name":"Arianna Dagliati","orcid":"https://orcid.org/0000-0002-5041-0409"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Arianna Dagliati","raw_affiliation_strings":["University of Pavia,Department of Industrial and Information Engineering,Pavia,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia,Department of Industrial and Information Engineering,Pavia,Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098815031","display_name":"Mahin Vazifehdan","orcid":"https://orcid.org/0009-0003-0506-306X"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mahin Vazifehdan","raw_affiliation_strings":["University of Pavia,Department of Industrial and Information Engineering,Pavia,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia,Department of Industrial and Information Engineering,Pavia,Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050932220","display_name":"Riccardo Bellazzi","orcid":"https://orcid.org/0000-0002-6974-9808"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccardo Bellazzi","raw_affiliation_strings":["University of Pavia,Department of Industrial and Information Engineering,Pavia,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia,Department of Industrial and Information Engineering,Pavia,Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047587986","display_name":"Isotta Trescato","orcid":"https://orcid.org/0000-0003-0625-993X"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Isotta Trescato","raw_affiliation_strings":["University of Padova,Department of Information Engineering,Padova,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Padova,Department of Information Engineering,Padova,Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061667028","display_name":"Alessandro Guazzo","orcid":"https://orcid.org/0000-0001-5155-2567"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Guazzo","raw_affiliation_strings":["University of Padova,Department of Information Engineering,Padova,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Padova,Department of Information Engineering,Padova,Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024366949","display_name":"Martina Vettoretti","orcid":"https://orcid.org/0000-0002-5020-1818"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Vettoretti","raw_affiliation_strings":["University of Padova,Department of Information Engineering,Padova,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Padova,Department of Information Engineering,Padova,Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016441737","display_name":"Eleonora Tavazzi","orcid":"https://orcid.org/0000-0003-2580-3646"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eleonora Tavazzi","raw_affiliation_strings":["Multiple Sclerosis Centre IRCCS Mondino Foundation,Pavia,Italy","University of Padova,Department of Information Engineering,Padova,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multiple Sclerosis Centre IRCCS Mondino Foundation,Pavia,Italy","institution_ids":[]},{"raw_affiliation_string":"University of Padova,Department of Information Engineering,Padova,Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057340064","display_name":"Lara Ahmad","orcid":"https://orcid.org/0000-0003-2463-6815"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lara Ahmad","raw_affiliation_strings":["Multiple Sclerosis Centre IRCCS Mondino Foundation,Pavia,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multiple Sclerosis Centre IRCCS Mondino Foundation,Pavia,Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008399548","display_name":"Roberto Bergamaschi","orcid":"https://orcid.org/0000-0002-1397-511X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto Bergamaschi","raw_affiliation_strings":["Multiple Sclerosis Centre IRCCS Mondino Foundation,Pavia,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multiple Sclerosis Centre IRCCS Mondino Foundation,Pavia,Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063501464","display_name":"Paola Cavalla","orcid":"https://orcid.org/0000-0003-4589-4864"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Cavalla","raw_affiliation_strings":["University of Turin,Department of Neurosciences \"Rita Levi Montalcini\",Torino,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turin,Department of Neurosciences \"Rita Levi Montalcini\",Torino,Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052801313","display_name":"Umberto Manera","orcid":"https://orcid.org/0000-0002-9995-8133"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Umberto Manera","raw_affiliation_strings":["University of Turin,Department of Neurosciences \"Rita Levi Montalcini\",Torino,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turin,Department of Neurosciences \"Rita Levi Montalcini\",Torino,Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090628289","display_name":"Adriano Chi\u00f2","orcid":"https://orcid.org/0000-0001-9579-5341"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Adriano Chi\u00f2","raw_affiliation_strings":["University of Turin,Department of Neurosciences \"Rita Levi Montalcini\",Torino,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turin,Department of Neurosciences \"Rita Levi Montalcini\",Torino,Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077821068","display_name":"Barbara Di Camillo","orcid":"https://orcid.org/0000-0001-8415-4688"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Di Camillo","raw_affiliation_strings":["University of Padova,Department of Information Engineering,Padova,Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Padova,Department of Information Engineering,Padova,Italy","institution_ids":["https://openalex.org/I138689650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"6161","last_page":"6168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5558550357818604},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"Multiple sclerosis","score":0.4907163381576538},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.42205584049224854},{"id":"https://openalex.org/keywords/weather-prediction","display_name":"Weather prediction","score":0.41299504041671753},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.32317230105400085},{"id":"https://openalex.org/keywords/meteorology","display_name":"Meteorology","score":0.29292112588882446},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24523183703422546},{"id":"https://openalex.org/keywords/geography","display_name":"Geography","score":0.17726638913154602}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5558550357818604},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.4907163381576538},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.42205584049224854},{"id":"https://openalex.org/C2987469573","wikidata":"https://www.wikidata.org/wiki/Q182868","display_name":"Weather prediction","level":2,"score":0.41299504041671753},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.32317230105400085},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.29292112588882446},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24523183703422546},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.17726638913154602},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibm62325.2024.10822214","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822214","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},{"id":"pmh:oai:www.research.unipd.it:11577/3546382","is_oa":false,"landing_page_url":"https://ieeexplore.ieee.org/document/10822214","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6399999856948853,"display_name":"Climate action","id":"https://metadata.un.org/sdg/13"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1987388972","https://openalex.org/W2101234009","https://openalex.org/W2112165124","https://openalex.org/W2224266618","https://openalex.org/W2559976784","https://openalex.org/W2574230683","https://openalex.org/W2607112601","https://openalex.org/W2792647451","https://openalex.org/W2802618774","https://openalex.org/W2992252352","https://openalex.org/W3112691794","https://openalex.org/W4393713763","https://openalex.org/W6676535487","https://openalex.org/W6863176011"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W4387369504","https://openalex.org/W3046775127","https://openalex.org/W4394896187","https://openalex.org/W3170094116","https://openalex.org/W4386462264","https://openalex.org/W3107602296","https://openalex.org/W4364306694","https://openalex.org/W4312192474"],"abstract_inverted_index":{"Multiple":[0],"Sclerosis":[1],"(MS)":[2],"is":[3,44],"a":[4,72,99,126],"chronic":[5],"autoimmune":[6],"and":[7,31,67,97,109,113,119,149,173,181,196,199],"inflammatory":[8],"neurological":[9],"disorder":[10],"characterised":[11],"by":[12],"episodes":[13],"of":[14,54,74,87,101,103,147,152,211],"symptom":[15],"exacerbation,":[16],"known":[17],"as":[18,28,163,185],"relapses.":[19],"Relapses":[20],"have":[21],"been":[22],"linked":[23],"to":[24],"environmental":[25,55,68,182,205],"factors":[26,56,206],"such":[27,162,184],"the":[29,35,38,52,78,85,88,133,141,174],"weather":[30],"pollutant":[32],"concentrations":[33],"in":[34,57,62,84,136,215],"air,":[36],"but":[37],"exact":[39],"relationship":[40],"between":[41],"these":[42],"phenomena":[43],"still":[45],"unclear.":[46],"In":[47],"this":[48],"study,":[49],"we":[50,95],"investigated":[51],"role":[53],"predicting":[58],"imminent":[59,212],"relapse":[60,213],"occurrence":[61,214],"MS":[63,166],"patients,":[64],"leveraging":[65],"clinical":[66,160],"data":[69,82],"collected":[70,83],"over":[71],"period":[73],"one":[75],"week":[76],"preceeding":[77],"possible":[79],"event,":[80],"using":[81],"context":[86],"H2020":[89],"BRAINTEASER":[90],"project.":[91],"To":[92],"do":[93],"this,":[94],"developed":[96],"tested":[98],"range":[100],"combinations":[102],"predictive":[104],"models":[105],"(logistic":[106],"regression,":[107],"LR;":[108],"random":[110],"forest,":[111],"RF)":[112],"feature":[114,128],"selection":[115,129],"schemes,":[116],"both":[117],"manual":[118],"data-driven.":[120],"The":[121],"RF":[122],"model":[123],"trained":[124],"after":[125],"data-driven":[127],"process":[130],"based":[131],"on":[132],"Variable":[134],"Importance":[135],"Projection":[137],"(VIP)":[138],"metric":[139],"yielded":[140],"best":[142],"results,":[143],"i.e.,":[144],"an":[145,150],"AUC-ROC":[146],"0.713":[148],"AUC-PR":[151],"0.639.":[153],"We":[154],"identified":[155],"several":[156],"key":[157],"predictors,":[158],"including":[159],"variables":[161,183],"time":[164],"since":[165],"onset,":[167,170],"age":[168],"at":[169],"diagnostic":[171],"delay,":[172],"Expanded":[175],"Disability":[176],"Status":[177],"Scale":[178],"(EDSS)":[179],"score,":[180],"wind":[186],"speed,":[187],"precipitation,":[188],"NO<inf":[189],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[190,193],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</inf>,":[191],"PM<inf":[192],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">10</inf>,":[194],"average":[195],"maximum":[197],"temperatures,":[198],"humidity.":[200],"These":[201],"findings":[202],"suggest":[203],"that":[204],"may":[207],"be":[208],"viable":[209],"predictors":[210],"MS.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}