{"id":"https://openalex.org/W4406260374","doi":"https://doi.org/10.1109/bibm62325.2024.10822036","title":"GT-KGCN: Gene Essentiality Prediction with Graph Transformer and Kolmogorov-Arnold Network","display_name":"GT-KGCN: Gene Essentiality Prediction with Graph Transformer and Kolmogorov-Arnold Network","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406260374","doi":"https://doi.org/10.1109/bibm62325.2024.10822036"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10822036","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822036","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rukai Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rukai Liu","raw_affiliation_strings":["Inner Mongolia University,College of Computer Science,Hohhot,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia University,College of Computer Science,Hohhot,China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028310649","display_name":"Bing Jia","orcid":"https://orcid.org/0000-0003-3294-6303"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Jia","raw_affiliation_strings":["Inner Mongolia University,College of Computer Science,Hohhot,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia University,College of Computer Science,Hohhot,China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062695688","display_name":"Baoqi Huang","orcid":"https://orcid.org/0000-0003-4027-1756"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baoqi Huang","raw_affiliation_strings":["Inner Mongolia University,College of Computer Science,Hohhot,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia University,College of Computer Science,Hohhot,China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036767777","display_name":"Winston K.G. Seah","orcid":"https://orcid.org/0000-0001-7147-5167"},"institutions":[{"id":"https://openalex.org/I41156924","display_name":"Victoria University of Wellington","ror":"https://ror.org/0040r6f76","country_code":"NZ","type":"education","lineage":["https://openalex.org/I41156924"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Winston K.G. Seah","raw_affiliation_strings":["Victoria University of Wellington,School of Engineering &#x0026; Computer Science,Wellington,New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Victoria University of Wellington,School of Engineering &#x0026; Computer Science,Wellington,New Zealand","institution_ids":["https://openalex.org/I41156924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111917510","display_name":"Fei Hao","orcid":null},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Hao","raw_affiliation_strings":["Inner Mongolia University,School of Life Science,Hohhot,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia University,School of Life Science,Hohhot,China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101968315","display_name":"Dongjun Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongjun Liu","raw_affiliation_strings":["Inner Mongolia University,School of Life Science,Hohhot,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia University,School of Life Science,Hohhot,China","institution_ids":["https://openalex.org/I2722730"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2041,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.58751568,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"1592","last_page":"1595"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9825999736785889,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.972599983215332,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5674570202827454},{"id":"https://openalex.org/keywords/transformer","display_name":"Transformer","score":0.5374714732170105},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.44395142793655396},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32817527651786804},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.2899623513221741},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.11158779263496399},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.090690016746521}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5674570202827454},{"id":"https://openalex.org/C66322947","wikidata":"https://www.wikidata.org/wiki/Q11658","display_name":"Transformer","level":3,"score":0.5374714732170105},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.44395142793655396},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32817527651786804},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.2899623513221741},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11158779263496399},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.090690016746521},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10822036","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822036","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4099999964237213,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322868","display_name":"Natural Science Foundation of Inner Mongolia","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W2008632223","https://openalex.org/W2130790725","https://openalex.org/W2135526239","https://openalex.org/W2790937047","https://openalex.org/W2912802963","https://openalex.org/W2915554882","https://openalex.org/W3042748728","https://openalex.org/W3187966659","https://openalex.org/W4385245566","https://openalex.org/W4390971257","https://openalex.org/W6726873649","https://openalex.org/W6867176674"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Identifying":[0],"essential":[1,162],"genes":[2],"in":[3,161],"an":[4],"organism":[5],"is":[6],"crucial":[7],"for":[8,22,50,58,68,131,135,139,144],"bioinformatics":[9],"and":[10,41,53,66,88,104,116,142,156,198],"genomics":[11],"research.":[12],"In":[13],"this":[14],"paper,":[15],"we":[16],"propose":[17],"a":[18,126],"new":[19],"computational":[20],"method":[21],"gene":[23,83,163,189],"similarity":[24],"prediction,":[25],"named":[26],"GT-KGCN,":[27],"which":[28],"combines":[29],"the":[30,33,93,169,182,186,193,200],"advantages":[31],"of":[32,61,95,109,129,172,185],"Graph":[34,37],"Transformer":[35],"(GT),":[36],"Convolutional":[38],"Network":[39,43],"(GCN),":[40],"Kolmogorov-Arnold":[42],"(KAN).":[44],"Specifically,":[45],"GT-KGCN":[46,96,124,148],"utilizes":[47],"graph":[48],"transformers":[49],"feature":[51,70],"embedding":[52],"multi-head":[54],"attention":[55],"aggregation,":[56],"GCN":[57],"hierarchical":[59],"aggregation":[60],"information":[62],"from":[63],"neighboring":[64],"nodes,":[65],"KAN":[67],"optimizing":[69],"learning":[71,154,159],"through":[72],"learnable":[73],"activation":[74],"functions.":[75],"Model":[76],"inputs":[77],"include":[78],"Protein-Protein":[79],"Interaction":[80],"(PPI)":[81],"networks,":[82],"expression":[84,190],"profiles,":[85],"subcellular":[86],"localization,":[87],"orthologs":[89],"information.":[90],"We":[91],"evaluated":[92],"performance":[94,184,196],"on":[97,181],"two":[98],"different":[99,178],"PPI":[100],"network":[101],"databases":[102],"(BioGRID":[103],"STRING)":[105],"using":[106],"multi-omics":[107,173],"datasets":[108,174],"Escherichia":[110,132],"coli,":[111,133],"Saccharomyces":[112,136],"cerevisiae,":[113,137],"Drosophila":[114,140],"melanogaster,":[115,141],"Homo":[117,145],"sapiens.":[118,146],"The":[119,147,165],"experimental":[120],"results":[121],"show":[122],"that":[123],"achieves":[125],"prediction":[127,183],"accuracy":[128],"99.12%":[130],"98.47%":[134],"92.22%":[138],"92.30%":[143],"model":[149],"outperforms":[150],"traditional":[151],"shallow":[152],"machine":[153],"methods":[155,160],"other":[157],"deep":[158],"prediction.":[164],"ablation":[166],"study":[167],"verifies":[168],"positive":[170],"effects":[171],"as":[175,177],"well":[176],"convolutional":[179],"layers":[180],"model,":[187],"with":[188],"data":[191],"showing":[192],"most":[194],"significant":[195],"improvement":[197],"demonstrating":[199],"model\u2019s":[201],"superiority.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
