{"id":"https://openalex.org/W4406271592","doi":"https://doi.org/10.1109/bibm62325.2024.10822016","title":"MDMD: A Computational Model for Predicting Drug-Related Microbes Based on the Aggregated Metapaths from a Heterogeneous Network","display_name":"MDMD: A Computational Model for Predicting Drug-Related Microbes Based on the Aggregated Metapaths from a Heterogeneous Network","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406271592","doi":"https://doi.org/10.1109/bibm62325.2024.10822016"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10822016","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822016","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041932219","display_name":"Jiajie Xing","orcid":null},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajie Xing","raw_affiliation_strings":["Inner Mongolia University,College of Computer Science,Hohhot,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia University,College of Computer Science,Hohhot,China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018529469","display_name":"Yuan Zhang","orcid":"https://orcid.org/0000-0002-4839-0218"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Zhang","raw_affiliation_strings":["Inner Mongolia University,College of Computer Science,Hohhot,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia University,College of Computer Science,Hohhot,China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100621288","display_name":"Jiaxuan Wang","orcid":"https://orcid.org/0009-0008-0450-6857"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxuan Wang","raw_affiliation_strings":["Inner Mongolia University,College of Computer Science,Hohhot,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia University,College of Computer Science,Hohhot,China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100773422","display_name":"Juan Wang","orcid":"https://orcid.org/0000-0002-8289-1614"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Wang","raw_affiliation_strings":["Inner Mongolia University,College of Computer Science,Hohhot,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia University,College of Computer Science,Hohhot,China","institution_ids":["https://openalex.org/I2722730"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2722730"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"6306","last_page":"6313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.683753252029419},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.48112550377845764},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.45707967877388},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.25687623023986816},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08832508325576782},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.08001023530960083}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.683753252029419},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48112550377845764},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.45707967877388},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.25687623023986816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08832508325576782},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.08001023530960083}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10822016","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10822016","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317803","display_name":"Education Department of Inner Mongolia Autonomous Region","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322868","display_name":"Natural Science Foundation of Inner Mongolia","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W103340358","https://openalex.org/W1510073064","https://openalex.org/W1533861849","https://openalex.org/W1577392641","https://openalex.org/W1980471449","https://openalex.org/W2012606594","https://openalex.org/W2016853666","https://openalex.org/W2078599166","https://openalex.org/W2087007556","https://openalex.org/W2096541451","https://openalex.org/W2104957671","https://openalex.org/W2106565661","https://openalex.org/W2124001239","https://openalex.org/W2129712434","https://openalex.org/W2159452112","https://openalex.org/W2162078360","https://openalex.org/W2168022112","https://openalex.org/W2322763599","https://openalex.org/W2563720483","https://openalex.org/W2583889943","https://openalex.org/W2618503740","https://openalex.org/W2740199405","https://openalex.org/W2743104969","https://openalex.org/W2767891136","https://openalex.org/W2769934873","https://openalex.org/W2770191688","https://openalex.org/W2788398649","https://openalex.org/W2799481458","https://openalex.org/W2806074960","https://openalex.org/W2807176368","https://openalex.org/W2901312953","https://openalex.org/W2903096015","https://openalex.org/W2911286998","https://openalex.org/W3005110075","https://openalex.org/W3037489518","https://openalex.org/W3107527779","https://openalex.org/W3116604690","https://openalex.org/W3119962804","https://openalex.org/W3138837064","https://openalex.org/W3192677404","https://openalex.org/W3206937279","https://openalex.org/W3217763658","https://openalex.org/W4213205106","https://openalex.org/W4220796987","https://openalex.org/W4225873739","https://openalex.org/W4231449374","https://openalex.org/W4282930057","https://openalex.org/W4295934099","https://openalex.org/W4297253807","https://openalex.org/W4297964735","https://openalex.org/W4309467503","https://openalex.org/W4311584330","https://openalex.org/W4313309561","https://openalex.org/W4318539234","https://openalex.org/W4318982906","https://openalex.org/W6603694148","https://openalex.org/W6758075616"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Clinical":[0],"studies":[1],"have":[2],"shown":[3],"that":[4,125,175,217,230],"microbes":[5,46,92,194,220],"in":[6,31,141,223,253,255,266],"the":[7,19,32,41,67,74,95,104,110,122,129,132,142,146,149,154,157,167,176,193,203,209,224,236,249,257,261,264,267],"human":[8,14],"body":[9],"are":[10,55,73,202,221],"closely":[11],"related":[12],"to":[13,39,89,152,191,207],"health.":[15],"Microbes":[16],"can":[17,126,165,269],"influence":[18],"activity":[20],"and":[21,45,50,78,114,139,199,263],"toxicity":[22],"of":[23,34,69,106,112,121,131,137,156,169,195,219,238,248,260],"drugs.":[24],"So":[25],"they":[26],"play":[27],"an":[28,119],"important":[29],"role":[30],"treatment":[33,237],"diseases.":[35],"It":[36],"is":[37,188,251],"critical":[38],"research":[40],"associations":[42,111],"between":[43,76],"drugs":[44,77,197,205],"for":[47,59,134,160,235],"drug":[48],"development":[49],"precision":[51],"medicine.":[52],"Recently,":[53],"there":[54],"several":[56],"computation":[57],"methods":[58,65],"predicting":[60],"drug-related":[61,91],"microbes.":[62,79],"However,":[63],"these":[64],"ignore":[66],"information":[68],"diseases":[70,72],"because":[71],"bridge":[75],"Here":[80],"we":[81,228],"introduce":[82],"a":[83,98],"new":[84],"model":[85],"(called":[86],"MDMD)":[87],"proposed":[88],"predict":[90,192],"based":[93],"on":[94],"Metapaths":[96],"from":[97],"heterogeneous":[99,143],"network":[100],"constructed":[101],"by":[102,180,241],"using":[103],"data":[105,265],"Diseases,":[107],"Microbes,":[108],"Drugs,":[109],"microbe-disease":[113],"disease-drug.":[115],"The":[116,186,214],"MDMD":[117,147,177,187,250,262],"uses":[118,148],"aggregation":[120],"metapath":[123,158],"features":[124,133],"effectively":[127],"abundance":[128],"embedding":[130],"different":[135],"types":[136],"nodes":[138],"edges":[140],"networks.":[144],"Then,":[145],"attention":[150],"mechanism":[151],"mark":[153],"importance":[155],"vector":[159],"each":[161],"node":[162],"type":[163],"which":[164,201,256],"improve":[166],"quality":[168],"feature":[170],"embedding.":[171],"Experimental":[172],"results":[173,215],"demonstrate":[174],"improves":[178],"accuracy":[179],"1.9%":[181],"compared":[182],"with":[183],"other":[184],"models.":[185],"also":[189],"used":[190,206],"two":[196],"Lamivudine":[198],"Tenofovir":[200],"antiretroviral":[204],"treat":[208],"Acquired":[210],"Immune":[211],"Deficiency":[212],"Syndrome(AIDS).":[213],"show":[216],"90-95%":[218],"reported":[222],"PubMed.":[225],"In":[226],"addition,":[227],"found":[229],"lamivudine":[231],"may":[232],"be":[233,270],"useful":[234],"tuberculosis":[239,243],"caused":[240],"Mycobacterium":[242],"(Mtb).":[244],"An":[245],"online":[246],"platform":[247],"available":[252],"https://mdmd2023.bit1024.top/,":[254],"source":[258],"code":[259],"work":[268],"downloaded.":[271]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
