{"id":"https://openalex.org/W4406260050","doi":"https://doi.org/10.1109/bibm62325.2024.10821992","title":"Predicting Alzheimer\u2019s Disease Progression using Time-Decay LSTM Network with Multi-Condition Variational Autoencoder","display_name":"Predicting Alzheimer\u2019s Disease Progression using Time-Decay LSTM Network with Multi-Condition Variational Autoencoder","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406260050","doi":"https://doi.org/10.1109/bibm62325.2024.10821992"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10821992","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821992","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108681526","display_name":"Qiao Pan","orcid":"https://orcid.org/0009-0004-1797-8643"},"institutions":[{"id":"https://openalex.org/I181326427","display_name":"Donghua University","ror":"https://ror.org/035psfh38","country_code":"CN","type":"education","lineage":["https://openalex.org/I181326427"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiao Pan","raw_affiliation_strings":["DongHua University,School of Computer Science and Technology,ShangHai,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DongHua University,School of Computer Science and Technology,ShangHai,China","institution_ids":["https://openalex.org/I181326427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351074","display_name":"Yan Liu","orcid":"https://orcid.org/0000-0002-3864-1992"},"institutions":[{"id":"https://openalex.org/I181326427","display_name":"Donghua University","ror":"https://ror.org/035psfh38","country_code":"CN","type":"education","lineage":["https://openalex.org/I181326427"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Liu","raw_affiliation_strings":["DongHua University,School of Computer Science and Technology,ShangHai,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DongHua University,School of Computer Science and Technology,ShangHai,China","institution_ids":["https://openalex.org/I181326427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100340627","display_name":"Qian Li","orcid":"https://orcid.org/0000-0002-8308-9551"},"institutions":[{"id":"https://openalex.org/I181326427","display_name":"Donghua University","ror":"https://ror.org/035psfh38","country_code":"CN","type":"education","lineage":["https://openalex.org/I181326427"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Li","raw_affiliation_strings":["DongHua University,School of Computer Science and Technology,ShangHai,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DongHua University,School of Computer Science and Technology,ShangHai,China","institution_ids":["https://openalex.org/I181326427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100375186","display_name":"Mei Wang","orcid":"https://orcid.org/0000-0001-7392-0850"},"institutions":[{"id":"https://openalex.org/I181326427","display_name":"Donghua University","ror":"https://ror.org/035psfh38","country_code":"CN","type":"education","lineage":["https://openalex.org/I181326427"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei Wang","raw_affiliation_strings":["DongHua University,School of Computer Science and Technology,ShangHai,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DongHua University,School of Computer Science and Technology,ShangHai,China","institution_ids":["https://openalex.org/I181326427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181326427"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2332","last_page":"2338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoencoder","display_name":"Autoencoder","score":0.901846170425415},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5010974407196045},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.48188120126724243},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4366304874420166},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.4200226664543152},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.35474079847335815},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.27715760469436646},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2562341094017029},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17079925537109375}],"concepts":[{"id":"https://openalex.org/C101738243","wikidata":"https://www.wikidata.org/wiki/Q786435","display_name":"Autoencoder","level":3,"score":0.901846170425415},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5010974407196045},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48188120126724243},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4366304874420166},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.4200226664543152},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.35474079847335815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27715760469436646},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2562341094017029},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17079925537109375}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10821992","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821992","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337504","display_name":"Research and Development","ror":"https://ror.org/027s68j25"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1910549955","https://openalex.org/W2001199794","https://openalex.org/W2088584394","https://openalex.org/W2106931873","https://openalex.org/W2782660935","https://openalex.org/W2797937217","https://openalex.org/W2807758560","https://openalex.org/W2886568032","https://openalex.org/W2899192510","https://openalex.org/W2909627766","https://openalex.org/W2944851425","https://openalex.org/W2963360736","https://openalex.org/W2975979380","https://openalex.org/W3008974784","https://openalex.org/W3047286661","https://openalex.org/W3080312596","https://openalex.org/W3163616589","https://openalex.org/W3204772083","https://openalex.org/W4211139529","https://openalex.org/W4255543091","https://openalex.org/W4292533844","https://openalex.org/W4319294776","https://openalex.org/W4386798087","https://openalex.org/W4387834977","https://openalex.org/W6726341914","https://openalex.org/W6749103444","https://openalex.org/W6751354539"],"related_works":["https://openalex.org/W3013693939","https://openalex.org/W2566616303","https://openalex.org/W2159052453","https://openalex.org/W3131327266","https://openalex.org/W2734887215","https://openalex.org/W2803255133","https://openalex.org/W4297051394","https://openalex.org/W2752972570","https://openalex.org/W4386815338","https://openalex.org/W4220775285"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"disease":[1,15,51],"(AD)":[2],"is":[3,11,76,129],"a":[4,56,62,97,132],"progressive":[5],"neurodegenerative":[6],"disorder,":[7],"where":[8],"early":[9,30],"diagnosis":[10],"critical":[12],"for":[13,20,29,149],"slowing":[14],"progression.":[16,52],"Cognitive":[17],"assessments,":[18],"known":[19],"their":[21],"high":[22],"sensitivity":[23],"and":[24,48,116,152],"specificity,":[25],"are":[26,38],"essential":[27],"tools":[28],"detection.":[31],"However,":[32],"clinical":[33],"data":[34,88],"from":[35,121],"AD":[36,147],"patients":[37],"often":[39],"incomplete,":[40],"posing":[41],"significant":[42],"challenges":[43],"in":[44,145],"predicting":[45,146],"cognitive":[46],"scores":[47],"accurately":[49],"assessing":[50],"This":[53,110],"paper":[54],"proposes":[55],"time-decay":[57],"LSTM":[58,134],"network":[59],"combined":[60],"with":[61,74],"Multi-Condition":[63],"Variational":[64],"Autoencoder":[65],"(MC-VAE)":[66],"to":[67,78],"address":[68],"these":[69],"challenges.":[70],"First,":[71],"the":[72,84,87,107,114,126,150],"MC-VAE":[73],"clustering":[75],"employed":[77],"effectively":[79,112],"impute":[80],"missing":[81],"values,":[82],"capturing":[83],"diversity":[85],"of":[86,102],"distribution":[89],"while":[90],"maintaining":[91],"its":[92],"discreteness":[93],"during":[94],"interpolation.":[95],"Next,":[96],"multi-representation":[98],"information":[99,128],"encoder,":[100],"composed":[101],"several":[103],"MUST-Encoding":[104],"components,":[105],"encodes":[106],"imputed":[108],"data.":[109],"process":[111],"captures":[113],"non-linear":[115],"non-periodic":[117],"temporal":[118],"patterns":[119],"arising":[120],"irregular":[122],"time":[123],"series.":[124],"Finally,":[125],"encoded":[127],"input":[130],"into":[131],"Time-Decay":[133],"network.":[135],"Experimental":[136],"results":[137],"validate":[138],"that":[139],"our":[140],"model":[141],"outperforms":[142],"conventional":[143],"methods":[144],"progression":[148],"ADNI":[151],"NACC":[153],"public":[154],"datasets.":[155]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}