{"id":"https://openalex.org/W4406238108","doi":"https://doi.org/10.1109/bibm62325.2024.10821966","title":"MFFL-DSR: A Multi-Feature Fusion Learning Method for Discovering the Synergistic Relationships between Psychotropic and Cardiovascular Drugs","display_name":"MFFL-DSR: A Multi-Feature Fusion Learning Method for Discovering the Synergistic Relationships between Psychotropic and Cardiovascular Drugs","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406238108","doi":"https://doi.org/10.1109/bibm62325.2024.10821966"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10821966","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821966","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100398661","display_name":"Ling Wang","orcid":"https://orcid.org/0000-0001-8964-6454"},"institutions":[{"id":"https://openalex.org/I179060312","display_name":"Northeast Electric Power University","ror":"https://ror.org/00zqaxa34","country_code":"CN","type":"education","lineage":["https://openalex.org/I179060312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Wang","raw_affiliation_strings":["Northeast Electric Power University,Computer Science and Technology, School of Computer Science,Jilin,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Electric Power University,Computer Science and Technology, School of Computer Science,Jilin,China","institution_ids":["https://openalex.org/I179060312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014454350","display_name":"Xi Wei Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I179060312","display_name":"Northeast Electric Power University","ror":"https://ror.org/00zqaxa34","country_code":"CN","type":"education","lineage":["https://openalex.org/I179060312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Wei Wang","raw_affiliation_strings":["Northeast Electric Power University,Computer Science and Technology, School of Computer Science,Jilin,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Electric Power University,Computer Science and Technology, School of Computer Science,Jilin,China","institution_ids":["https://openalex.org/I179060312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074232429","display_name":"Tie Hua Zhou","orcid":"https://orcid.org/0000-0002-3258-0244"},"institutions":[{"id":"https://openalex.org/I179060312","display_name":"Northeast Electric Power University","ror":"https://ror.org/00zqaxa34","country_code":"CN","type":"education","lineage":["https://openalex.org/I179060312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tie Hua Zhou","raw_affiliation_strings":["Northeast Electric Power University,Computer Science and Technology, School of Computer Science,Jilin,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Electric Power University,Computer Science and Technology, School of Computer Science,Jilin,China","institution_ids":["https://openalex.org/I179060312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031885220","display_name":"Tian Yu Jin","orcid":"https://orcid.org/0009-0008-0909-0854"},"institutions":[{"id":"https://openalex.org/I179060312","display_name":"Northeast Electric Power University","ror":"https://ror.org/00zqaxa34","country_code":"CN","type":"education","lineage":["https://openalex.org/I179060312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Yu Jin","raw_affiliation_strings":["Northeast Electric Power University,Computer Science and Technology, School of Computer Science,Jilin,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Electric Power University,Computer Science and Technology, School of Computer Science,Jilin,China","institution_ids":["https://openalex.org/I179060312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069882603","display_name":"Zheng Yang Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I179060312","display_name":"Northeast Electric Power University","ror":"https://ror.org/00zqaxa34","country_code":"CN","type":"education","lineage":["https://openalex.org/I179060312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Yang Zhang","raw_affiliation_strings":["Northeast Electric Power University,Computer Science and Technology, School of Computer Science,Jilin,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Electric Power University,Computer Science and Technology, School of Computer Science,Jilin,China","institution_ids":["https://openalex.org/I179060312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043932631","display_name":"Keun Ho Ryu","orcid":"https://orcid.org/0000-0003-0394-9054"},"institutions":[{"id":"https://openalex.org/I141445968","display_name":"Ton Duc Thang University","ror":"https://ror.org/01drq0835","country_code":"VN","type":"education","lineage":["https://openalex.org/I141445968"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Keun Ho Ryu","raw_affiliation_strings":["Ton Duc Thang University,Faculty of Information Technology,Ho Chi Minh City,Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ton Duc Thang University,Faculty of Information Technology,Ho Chi Minh City,Vietnam","institution_ids":["https://openalex.org/I141445968"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3205,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.66077959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"7150","last_page":"7152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9588000178337097,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9588000178337097,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6953814625740051},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.595284640789032},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4986879825592041},{"id":"https://openalex.org/keywords/fusion","display_name":"Fusion","score":0.44080305099487305},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.32735198736190796}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6953814625740051},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.595284640789032},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4986879825592041},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.44080305099487305},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.32735198736190796},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10821966","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821966","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.699999988079071}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1578104218","https://openalex.org/W2767891136","https://openalex.org/W2946438679","https://openalex.org/W3139253280","https://openalex.org/W3165195325","https://openalex.org/W3208102118","https://openalex.org/W4313405519"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W4387369504","https://openalex.org/W3046775127","https://openalex.org/W4394896187","https://openalex.org/W3170094116","https://openalex.org/W4386462264","https://openalex.org/W3107602296","https://openalex.org/W4364306694","https://openalex.org/W4312192474"],"abstract_inverted_index":{"Cardiovascular":[0],"disease":[1],"and":[2,10,42,101],"depression":[3],"often":[4],"require":[5],"combined":[6],"use":[7],"of":[8,34],"cardiovascular":[9],"psychotropic":[11],"drugs.":[12],"This":[13],"paper":[14],"introduces":[15],"Multi-Feature":[16],"Fusion":[17],"Learning":[18],"for":[19],"Discovering":[20],"Synergistic":[21],"Relationships":[22],"(MFFL-DSR),":[23],"a":[24,54],"method":[25],"to":[26,63],"predict":[27],"drug":[28,35,65,83],"interactions.":[29],"It":[30],"first":[31],"constructs":[32],"matrices":[33],"features,":[36],"including":[37],"classification,":[38],"targets,":[39],"enzymes,":[40],"pathways,":[41],"molecular":[43],"structure.":[44],"Drugs":[45],"from":[46],"different":[47],"feature":[48],"domains":[49],"are":[50],"then":[51],"projected":[52],"into":[53],"shared":[55],"interaction":[56],"domain.":[57],"A":[58],"regularization":[59],"term":[60],"is":[61],"formulated":[62],"represent":[64],"pairing":[66],"relationships":[67],"in":[68,93],"the":[69,73],"inter-action":[70],"space,":[71],"forming":[72],"MFFL-DSR":[74,89],"objective":[75],"function.":[76],"Finally,":[77],"iterative":[78],"optimization":[79],"identifies":[80],"all":[81],"potential":[82],"combinations.":[84],"The":[85],"results":[86],"show":[87],"that":[88],"outperforms":[90],"baseline":[91],"methods":[92],"six":[94],"metrics:":[95],"AUPR,":[96],"AUC,":[97],"Precision,":[98],"Accuracy,":[99],"Recall,":[100],"F1":[102],"score.":[103]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}