{"id":"https://openalex.org/W4406262147","doi":"https://doi.org/10.1109/bibm62325.2024.10821915","title":"Identifying brain disease genes via integrating brain imaging and molecular network","display_name":"Identifying brain disease genes via integrating brain imaging and molecular network","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406262147","doi":"https://doi.org/10.1109/bibm62325.2024.10821915"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10821915","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821915","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100391700","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0001-6853-7785"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Northwestern Polytechnical University,School of Computer Science,Xi’an,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern Polytechnical University,School of Computer Science,Xi’an,China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101477538","display_name":"Yuxian Wang","orcid":"https://orcid.org/0000-0002-3450-2565"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxian Wang","raw_affiliation_strings":["Northwestern Polytechnical University,School of Computer Science,Xi’an,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern Polytechnical University,School of Computer Science,Xi’an,China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086535409","display_name":"Jiajie Peng","orcid":null},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajie Peng","raw_affiliation_strings":["Northwestern Polytechnical University,School of Computer Science,Xi’an,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern Polytechnical University,School of Computer Science,Xi’an,China","institution_ids":["https://openalex.org/I17145004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I17145004"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1207","last_page":"1212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9057000279426575,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9057000279426575,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-disease","display_name":"Brain disease","score":0.5936741232872009},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.5474553108215332},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5208193063735962},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.48258888721466064},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.47540029883384705},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3965066969394684},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3554800748825073},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22333785891532898},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22315430641174316},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1480971872806549},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.11005207896232605}],"concepts":[{"id":"https://openalex.org/C2991673738","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Brain disease","level":3,"score":0.5936741232872009},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5474553108215332},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5208193063735962},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48258888721466064},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47540029883384705},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3965066969394684},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3554800748825073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22333785891532898},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22315430641174316},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1480971872806549},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11005207896232605}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10821915","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821915","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1498123445","https://openalex.org/W1993673892","https://openalex.org/W1995978685","https://openalex.org/W2024729467","https://openalex.org/W2096173332","https://openalex.org/W2476779615","https://openalex.org/W2556519015","https://openalex.org/W2797105966","https://openalex.org/W2800243708","https://openalex.org/W2900569176","https://openalex.org/W2951422523","https://openalex.org/W2983166786","https://openalex.org/W3010830252","https://openalex.org/W3118069393","https://openalex.org/W3211333882","https://openalex.org/W4311904335","https://openalex.org/W4311963244","https://openalex.org/W4313368047","https://openalex.org/W4319997081","https://openalex.org/W4381435341","https://openalex.org/W4386471322","https://openalex.org/W4387225979","https://openalex.org/W4391140461","https://openalex.org/W4392607741","https://openalex.org/W6678885109"],"related_works":["https://openalex.org/W2327340211","https://openalex.org/W2027542625","https://openalex.org/W4292199793","https://openalex.org/W2282195379","https://openalex.org/W2089784006","https://openalex.org/W2295388821","https://openalex.org/W2102312026","https://openalex.org/W2071433170","https://openalex.org/W2885663991","https://openalex.org/W1016623679"],"abstract_inverted_index":{"Identifying":[0],"genes":[1,118,139],"associate":[2],"to":[3,20,80,113,135],"brain":[4,45,50,74,82,94,122,137,167,184,190],"diseases":[5],"is":[6,111],"crucial":[7],"for":[8,15,36,188],"uncovering":[9],"the":[10,21,121,159,173,180,183],"related":[11],"biological":[12,28],"mechanisms":[13],"and":[14,76,96,106,178],"advancing":[16],"therapeutic":[17],"interventions.":[18],"Due":[19],"ongoing":[22],"advancements":[23],"in":[24,57,158],"network-based":[25],"computational":[26],"approaches,":[27],"networks,":[29,32],"especially":[30],"molecular":[31],"provide":[33],"valuable":[34],"insights":[35],"predicting":[37,189],"disease":[38,51,83,138,162,191],"genes.":[39,84,192],"However,":[40],"many":[41],"methods":[42,157],"have":[43],"ignored":[44],"imaging":[46,75,95],"data":[47],"when":[48],"exploring":[49],"genes,":[52],"despite":[53],"its":[54],"widely":[55],"use":[56],"neuroscience":[58],"research.":[59],"In":[60],"this":[61],"paper,":[62],"we":[63,150],"propose":[64],"a":[65,88,104,141],"novel":[66],"framework,":[67],"Deep":[68],"Interactive":[69],"AutoEncoder":[70],"(DIAE),":[71],"which":[72],"integrates":[73],"molecular-based":[77,127],"gene":[78,89,100,128,163,186],"networks":[79],"predict":[81,136],"DIAE":[85,152,177],"first":[86],"constructs":[87],"association":[90],"network":[91,124,187],"based":[92],"on":[93],"high-resolution":[97],"whole":[98],"brain-whole":[99],"expression":[101],"data.":[102],"Subsequently,":[103],"deep":[105],"interactive":[107],"multi-network":[108],"integration":[109],"method":[110],"introduced":[112],"learn":[114],"low-dimensional":[115],"features":[116,132],"of":[117,161,176,182],"by":[119],"combining":[120],"imaging-based":[123,185],"with":[125,153],"other":[126],"networks.":[129],"Finally,":[130],"these":[131],"are":[133],"utilized":[134],"using":[140],"support":[142],"vector":[143],"machine":[144],"(SVM)":[145],"model.":[146],"For":[147],"performance":[148,175],"evaluation,":[149],"compare":[151],"three":[154],"existing":[155],"state-of-the-art":[156],"context":[160],"identification":[164],"across":[165],"four":[166],"diseases.":[168],"The":[169],"experimental":[170],"results":[171],"show":[172],"superior":[174],"highlight":[179],"effectiveness":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}