{"id":"https://openalex.org/W4406262111","doi":"https://doi.org/10.1109/bibm62325.2024.10821876","title":"ADiffGDA: Exploring Gene-Drug Associations via Adaptive Graph Diffusion Networks","display_name":"ADiffGDA: Exploring Gene-Drug Associations via Adaptive Graph Diffusion Networks","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406262111","doi":"https://doi.org/10.1109/bibm62325.2024.10821876"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10821876","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821876","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045260031","display_name":"Che Zhang","orcid":"https://orcid.org/0000-0001-6757-4306"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Che Zhang","raw_affiliation_strings":["Xinjiang University,School of Software,Urumqi,China"],"affiliations":[{"raw_affiliation_string":"Xinjiang University,School of Software,Urumqi,China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032822444","display_name":"Yanhao Fan","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhao Fan","raw_affiliation_strings":["Central South University,School of Computer Science and Engineering,Changsha,China"],"affiliations":[{"raw_affiliation_string":"Central South University,School of Computer Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101610203","display_name":"Xiaowen Hu","orcid":"https://orcid.org/0000-0002-7339-3007"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowen Hu","raw_affiliation_strings":["Central South University,School of Computer Science and Engineering,Changsha,China"],"affiliations":[{"raw_affiliation_string":"Central South University,School of Computer Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002981402","display_name":"Yurong Qian","orcid":"https://orcid.org/0000-0001-6564-4745"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yurong Qian","raw_affiliation_strings":["Xinjiang University,School of Software,Urumqi,China"],"affiliations":[{"raw_affiliation_string":"Xinjiang University,School of Software,Urumqi,China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113262237","display_name":"Lei Deng","orcid":null},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Deng","raw_affiliation_strings":["Xinjiang University,School of Software,Urumqi,China"],"affiliations":[{"raw_affiliation_string":"Xinjiang University,School of Software,Urumqi,China","institution_ids":["https://openalex.org/I96908189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5045260031"],"corresponding_institution_ids":["https://openalex.org/I96908189"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22099878,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"140","last_page":"145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5623884201049805},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5431264638900757},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.4427621364593506},{"id":"https://openalex.org/keywords/graph-theory","display_name":"Graph theory","score":0.4407527446746826},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.4385736286640167},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.28047609329223633},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.16884219646453857},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14970886707305908},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1341666579246521},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10355672240257263}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5623884201049805},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5431264638900757},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.4427621364593506},{"id":"https://openalex.org/C88230418","wikidata":"https://www.wikidata.org/wiki/Q131476","display_name":"Graph theory","level":2,"score":0.4407527446746826},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.4385736286640167},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.28047609329223633},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.16884219646453857},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14970886707305908},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1341666579246521},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10355672240257263},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10821876","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821876","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1974534998","https://openalex.org/W1985270532","https://openalex.org/W2028279608","https://openalex.org/W2066201825","https://openalex.org/W2073415627","https://openalex.org/W2091439417","https://openalex.org/W2094611598","https://openalex.org/W2106417713","https://openalex.org/W2111708605","https://openalex.org/W2127553917","https://openalex.org/W2735272571","https://openalex.org/W2775185492","https://openalex.org/W2802314916","https://openalex.org/W2907492528","https://openalex.org/W3045200674","https://openalex.org/W3093030756","https://openalex.org/W3097794447","https://openalex.org/W3120280121","https://openalex.org/W3158143432","https://openalex.org/W3170286690","https://openalex.org/W3213337333","https://openalex.org/W4210607727","https://openalex.org/W4220710781","https://openalex.org/W4225402571","https://openalex.org/W4386316616","https://openalex.org/W4388615780","https://openalex.org/W4392523524","https://openalex.org/W6680012447","https://openalex.org/W6680830989","https://openalex.org/W6720006811","https://openalex.org/W6745537798","https://openalex.org/W6804167365","https://openalex.org/W6840404458"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Exploring":[0],"gene-drug":[1,86],"associations":[2],"is":[3,113],"a":[4,78,117,168],"key":[5,109],"step":[6],"in":[7,30,37,142],"identifying":[8],"new":[9],"drug":[10],"candidates,":[11],"but":[12],"traditional":[13],"experimental":[14],"methods":[15],"are":[16,101,184],"often":[17],"expensive":[18],"and":[19,69,98,145,180],"time-consuming.":[20],"While":[21],"Graph":[22],"Neural":[23],"Network":[24],"(GNN)-based":[25],"models":[26,44],"have":[27],"demonstrated":[28],"effectiveness":[29,166],"association":[31,87],"prediction":[32],"tasks,":[33],"they":[34],"face":[35],"challenges":[36],"the":[38,114,136],"information":[39,106],"aggregation":[40,126],"process.":[41],"Existing":[42],"GNN":[43],"either":[45],"treat":[46],"all":[47],"nodes":[48],"uniformly":[49],"or":[50],"rely":[51],"on":[52,129],"simple":[53],"attention":[54],"mechanisms":[55],"to":[56,59,65,123,138],"assign":[57],"weights":[58,127],"neighboring":[60],"nodes,":[61],"limiting":[62],"their":[63],"capacity":[64],"capture":[66,140],"complex":[67],"relationships":[68],"improve":[70],"performance.":[71],"To":[72],"address":[73],"these":[74],"limitations,":[75],"we":[76,153],"propose":[77],"novel":[79],"adaptive":[80],"graph":[81],"diffusion":[82],"network,":[83],"ADiffGDA,":[84],"for":[85,96,174,182],"prediction.":[88],"The":[89,178],"model":[90,137],"begins":[91],"by":[92],"randomly":[93],"initializing":[94],"embeddings":[95],"genes":[97],"drugs,":[99],"which":[100],"then":[102],"updated":[103],"through":[104],"neighborhood":[105,147],"aggregation.":[107],"A":[108],"feature":[110],"of":[111,116],"ADiffGDA":[112,156,183],"incorporation":[115],"heat":[118],"kernel,":[119],"enabling":[120],"each":[121],"node":[122,143],"dynamically":[124],"adjust":[125],"based":[128],"its":[130,165],"local":[131,146],"structure.":[132],"This":[133],"approach":[134],"allows":[135],"better":[139],"variations":[141],"types":[144],"patterns.":[148],"Through":[149],"extensive":[150],"comparative":[151],"experiments,":[152],"show":[154],"that":[155],"outperforms":[157],"existing":[158],"state-of-the-art":[159],"methods.":[160],"Furthermore,":[161],"case":[162],"studies":[163],"validate":[164],"as":[167],"predictive":[169],"tool,":[170],"offering":[171],"valuable":[172],"insights":[173],"future":[175],"biological":[176],"experiments.":[177],"code":[179],"datasets":[181],"freely":[185],"available":[186],"at":[187],"https://github.com/one-melon/ADiffGDA.":[188]},"counts_by_year":[],"updated_date":"2025-12-22T23:10:17.713674","created_date":"2025-10-10T00:00:00"}