{"id":"https://openalex.org/W4406260037","doi":"https://doi.org/10.1109/bibm62325.2024.10821755","title":"Image2SignalNet: Image-based deep learning approach for capturing neuronal signals from calcium imaging","display_name":"Image2SignalNet: Image-based deep learning approach for capturing neuronal signals from calcium imaging","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406260037","doi":"https://doi.org/10.1109/bibm62325.2024.10821755"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10821755","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821755","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111296924","display_name":"Eunjung Jo","orcid":null},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunjung Jo","raw_affiliation_strings":["Korea University,Dept. of Artificial Intelligence,Seoul,South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea University,Dept. of Artificial Intelligence,Seoul,South Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066958234","display_name":"Dong-Hee Shin","orcid":"https://orcid.org/0000-0002-1008-2009"},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Hee Shin","raw_affiliation_strings":["Korea University,Dept. of Artificial Intelligence,Seoul,South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea University,Dept. of Artificial Intelligence,Seoul,South Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086054502","display_name":"Ji-Hye Oh","orcid":"https://orcid.org/0009-0008-0157-0706"},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Hye Oh","raw_affiliation_strings":["Korea University,Dept. of Artificial Intelligence,Seoul,South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea University,Dept. of Artificial Intelligence,Seoul,South Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083705796","display_name":"Sanghyeon Cho","orcid":"https://orcid.org/0009-0004-9945-4498"},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sanghyeon Cho","raw_affiliation_strings":["Korea University,Dept. of Artificial Intelligence,Seoul,South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea University,Dept. of Artificial Intelligence,Seoul,South Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109419944","display_name":"Hyun Jung Lee","orcid":"https://orcid.org/0009-0000-9682-7544"},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Jung Lee","raw_affiliation_strings":["Korea University,Dept. of Artificial Intelligence,Seoul,South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea University,Dept. of Artificial Intelligence,Seoul,South Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075267855","display_name":"Tae\u2010Eui Kam","orcid":"https://orcid.org/0000-0002-6677-7176"},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae-Eui Kam","raw_affiliation_strings":["Korea University,Dept. of Artificial Intelligence,Seoul,South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea University,Dept. of Artificial Intelligence,Seoul,South Korea","institution_ids":["https://openalex.org/I197347611"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I197347611"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15191337,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"3357","last_page":"3360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9857000112533569,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9857000112533569,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.9071000218391418,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-imaging","display_name":"Calcium imaging","score":0.7228244543075562},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6121898889541626},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5890897512435913},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5672428607940674},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.46368589997291565},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.44076403975486755},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4006582200527191},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3488617539405823},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3389131724834442},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.17103645205497742},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.10777539014816284}],"concepts":[{"id":"https://openalex.org/C2776032975","wikidata":"https://www.wikidata.org/wiki/Q5018833","display_name":"Calcium imaging","level":3,"score":0.7228244543075562},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6121898889541626},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5890897512435913},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5672428607940674},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.46368589997291565},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.44076403975486755},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4006582200527191},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3488617539405823},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3389131724834442},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17103645205497742},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.10777539014816284},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10821755","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821755","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321373","display_name":"Korea University","ror":"https://ror.org/047dqcg40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1977530624","https://openalex.org/W1982918139","https://openalex.org/W2069644094","https://openalex.org/W2086871516","https://openalex.org/W2090206974","https://openalex.org/W2171332611","https://openalex.org/W2512047842","https://openalex.org/W2794648976","https://openalex.org/W2913083484","https://openalex.org/W2950205567","https://openalex.org/W3133698431","https://openalex.org/W3191325495","https://openalex.org/W3195625084","https://openalex.org/W4200512433","https://openalex.org/W4206792024","https://openalex.org/W4220740615","https://openalex.org/W4294251987","https://openalex.org/W4297243218","https://openalex.org/W4366824614"],"related_works":["https://openalex.org/W1499732058","https://openalex.org/W2048213734","https://openalex.org/W1989673413","https://openalex.org/W1568635045","https://openalex.org/W4226087776","https://openalex.org/W4375867731","https://openalex.org/W2371794589","https://openalex.org/W2315373624","https://openalex.org/W1967736413","https://openalex.org/W2140812068"],"abstract_inverted_index":{"Two-photon":[0],"calcium":[1,53,100,109,131],"imaging":[2,54,101,110,132],"is":[3],"a":[4,24,141],"powerful":[5],"technique":[6],"for":[7,94],"recording":[8],"neuronal":[9,17,35,50,73,84,96],"activities":[10],"over":[11],"extended":[12],"periods.":[13],"However,":[14],"reliably":[15],"capturing":[16,83],"signals":[18,51,74],"from":[19,52,75],"the":[20,88,106,114,128],"this":[21,38],"data":[22,111,133],"poses":[23],"significant":[25,89,123],"challenge":[26],"due":[27],"to":[28,46,140],"non-uniform":[29],"neuropil":[30],"distribution":[31],"and":[32],"densely":[33],"packed":[34],"populations.":[36],"In":[37],"study,":[39],"we":[40,64,104],"leverage":[41],"deep":[42],"learning":[43],"(DL)":[44],"techniques":[45],"directly":[47,71],"capture":[48],"true":[49],"data,":[55],"addressing":[56],"these":[57],"challenges":[58],"effectively.":[59],"Utilizing":[60],"publicly":[61],"available":[62],"datasets,":[63],"demonstrate":[65],"that":[66],"our":[67,120],"DL-based":[68],"approach,":[69],"which":[70],"extracts":[72],"images,":[76],"outperforms":[77],"existing":[78],"non-DL":[79],"methods":[80,93],"in":[81,99,127],"accurately":[82],"signals.":[85],"This":[86],"highlights":[87],"potential":[90],"of":[91,108,116,130,144],"DL":[92,117,137],"unveiling":[95],"activity":[97],"hidden":[98],"data.":[102],"Furthermore,":[103],"investigate":[105],"impact":[107],"quality":[112,129],"on":[113],"performance":[115],"models.":[118],"While":[119],"approach":[121],"demonstrates":[122],"promise,":[124],"ongoing":[125],"improvements":[126],"will":[134],"further":[135],"enhance":[136],"techniques,":[138],"leading":[139],"deeper":[142],"understanding":[143],"brain":[145],"mechanisms.":[146]},"counts_by_year":[],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}