{"id":"https://openalex.org/W4406260163","doi":"https://doi.org/10.1109/bibm62325.2024.10821754","title":"A Three-Step Framework for Automatically Registering Immunohistochemical and H&E Stained Whole Slide Images Targeting Clinical Applications","display_name":"A Three-Step Framework for Automatically Registering Immunohistochemical and H&E Stained Whole Slide Images Targeting Clinical Applications","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406260163","doi":"https://doi.org/10.1109/bibm62325.2024.10821754"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10821754","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821754","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yingjia Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yingjia Yang","raw_affiliation_strings":["Wuhan University,Institute of Artificial Intelligence, School of Computer Science,Wuhan,China"],"affiliations":[{"raw_affiliation_string":"Wuhan University,Institute of Artificial Intelligence, School of Computer Science,Wuhan,China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344883","display_name":"Yuan Wang","orcid":"https://orcid.org/0000-0002-9100-5194"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Wang","raw_affiliation_strings":["Wuhan University,Institute of Artificial Intelligence, School of Computer Science,Wuhan,China"],"affiliations":[{"raw_affiliation_string":"Wuhan University,Institute of Artificial Intelligence, School of Computer Science,Wuhan,China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100354236","display_name":"Cheng Li","orcid":"https://orcid.org/0000-0002-0892-4705"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cheng Li","raw_affiliation_strings":["Landing Intelligent Medicine Co., Ltd,Landing Artificial Intelligence Centre for Pathological Diagnosis,Wuhan,China"],"affiliations":[{"raw_affiliation_string":"Landing Intelligent Medicine Co., Ltd,Landing Artificial Intelligence Centre for Pathological Diagnosis,Wuhan,China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058197209","display_name":"Dehua Cao","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dehua Cao","raw_affiliation_strings":["Landing Intelligent Medicine Co., Ltd,Landing Artificial Intelligence Centre for Pathological Diagnosis,Wuhan,China"],"affiliations":[{"raw_affiliation_string":"Landing Intelligent Medicine Co., Ltd,Landing Artificial Intelligence Centre for Pathological Diagnosis,Wuhan,China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110954839","display_name":"Baochuan Pang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Baochuan Pang","raw_affiliation_strings":["Landing Intelligent Medicine Co., Ltd,Landing Artificial Intelligence Centre for Pathological Diagnosis,Wuhan,China"],"affiliations":[{"raw_affiliation_string":"Landing Intelligent Medicine Co., Ltd,Landing Artificial Intelligence Centre for Pathological Diagnosis,Wuhan,China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054898850","display_name":"Hailian Xiao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210159820","display_name":"Weifang Maternity and Child Care Hospital","ror":"https://ror.org/05j6mnq41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hailian Xiao","raw_affiliation_strings":["Wei County Maternal and Child Health Hospital,Handan,China"],"affiliations":[{"raw_affiliation_string":"Wei County Maternal and Child Health Hospital,Handan,China","institution_ids":["https://openalex.org/I4210159820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100377340","display_name":"Junfeng Wang","orcid":"https://orcid.org/0000-0003-0837-7577"},"institutions":[{"id":"https://openalex.org/I4210159820","display_name":"Weifang Maternity and Child Care Hospital","ror":"https://ror.org/05j6mnq41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junfeng Wang","raw_affiliation_strings":["Wei County Maternal and Child Health Hospital,Handan,China"],"affiliations":[{"raw_affiliation_string":"Wei County Maternal and Child Health Hospital,Handan,China","institution_ids":["https://openalex.org/I4210159820"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100446344","display_name":"Juan Liu","orcid":"https://orcid.org/0000-0003-4963-6694"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Liu","raw_affiliation_strings":["Wuhan University,Institute of Artificial Intelligence, School of Computer Science,Wuhan,China"],"affiliations":[{"raw_affiliation_string":"Wuhan University,Institute of Artificial Intelligence, School of Computer Science,Wuhan,China","institution_ids":["https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I37461747"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.41762401,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"3887","last_page":"3890"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.980400025844574,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.980400025844574,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9714999794960022,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.6763105392456055},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6544438600540161},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.43352869153022766},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.3818334639072418},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.22520455718040466},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16413599252700806}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6763105392456055},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6544438600540161},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.43352869153022766},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.3818334639072418},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22520455718040466},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16413599252700806}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10821754","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821754","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","score":0.44999998807907104,"id":"https://metadata.un.org/sdg/9"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320329542","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1548529611","https://openalex.org/W1969013163","https://openalex.org/W2085261163","https://openalex.org/W2120967246","https://openalex.org/W2151103935","https://openalex.org/W2625405520","https://openalex.org/W3013056581","https://openalex.org/W3015206436","https://openalex.org/W3029707943","https://openalex.org/W3134976640","https://openalex.org/W3170373133","https://openalex.org/W3187676753","https://openalex.org/W4212903321","https://openalex.org/W4220857768","https://openalex.org/W4385787393"],"related_works":["https://openalex.org/W2772917594","https://openalex.org/W2036807459","https://openalex.org/W2058170566","https://openalex.org/W2755342338","https://openalex.org/W2166024367","https://openalex.org/W3116076068","https://openalex.org/W2229312674","https://openalex.org/W2951359407","https://openalex.org/W2079911747","https://openalex.org/W1969923398"],"abstract_inverted_index":{"Joint":[0],"analysis":[1],"of":[2,31,70],"multiple":[3],"biomarker":[4],"images":[5],"and":[6,18,34,36,62,80],"tissue":[7],"morphology":[8],"plays":[9],"an":[10],"important":[11],"role":[12],"in":[13],"disease":[14],"diagnosis,":[15],"treatment":[16],"planning,":[17],"drug":[19],"development.":[20],"This":[21],"necessitates":[22],"precise":[23],"cross-staining":[24,52,82],"comparison":[25],"among":[26],"Whole":[27],"Slide":[28],"Images":[29],"(WSIs)":[30],"immunohistochemical":[32],"(IHC)":[33],"hematoxylin":[35],"eosin":[37],"(H&E)":[38],"stained":[39],"microscopic":[40],"slides.":[41],"In":[42],"this":[43],"paper,":[44],"we":[45],"propose":[46],"a":[47,78],"novel":[48],"three-step,":[49],"feature-based,":[50],"automatic":[51],"WSI":[53],"alignment":[54,84],"method":[55],"to":[56,86],"support":[57],"clinical":[58],"practice.":[59],"The":[60],"comparative":[61],"ablation":[63],"experiments":[64],"have":[65],"shown":[66],"the":[67],"good":[68],"performance":[69],"our":[71],"method,":[72],"suggesting":[73],"that":[74],"it":[75],"can":[76],"offer":[77],"simple":[79],"effective":[81],"WSIs":[83],"contributing":[85],"pathological":[87],"diagnosis.":[88]},"counts_by_year":[],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}