{"id":"https://openalex.org/W4406271298","doi":"https://doi.org/10.1109/bibm62325.2024.10821749","title":"AI-Enhanced Detection of Cellular Aggregate Biomarkers For Point-of-Care Using Digital Holographic Microscopy","display_name":"AI-Enhanced Detection of Cellular Aggregate Biomarkers For Point-of-Care Using Digital Holographic Microscopy","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406271298","doi":"https://doi.org/10.1109/bibm62325.2024.10821749"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10821749","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821749","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101504866","display_name":"Qianyu Chen","orcid":"https://orcid.org/0000-0002-4098-5735"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Qianyu Chen","raw_affiliation_strings":["Technical University of Munich TUMCREATE,Singapore"],"affiliations":[{"raw_affiliation_string":"Technical University of Munich TUMCREATE,Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079573229","display_name":"Matthew E. Cove","orcid":"https://orcid.org/0000-0003-3805-4680"},"institutions":[{"id":"https://openalex.org/I4210146690","display_name":"National University Hospital","ror":"https://ror.org/04fp9fm22","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210146690"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Matthew Edward Cove","raw_affiliation_strings":["National University Hospital,Singapore"],"affiliations":[{"raw_affiliation_string":"National University Hospital,Singapore","institution_ids":["https://openalex.org/I4210146690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025491363","display_name":"Kerem Delikoyun","orcid":"https://orcid.org/0000-0002-3294-049X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kerem Delikoyun","raw_affiliation_strings":["Technical University of Munich TUMCREATE,Singapore"],"affiliations":[{"raw_affiliation_string":"Technical University of Munich TUMCREATE,Singapore","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074346065","display_name":"Klaus Diepold","orcid":"https://orcid.org/0000-0003-0439-7511"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus Diepold","raw_affiliation_strings":["Technical University of Munich,Munich,Germany"],"affiliations":[{"raw_affiliation_string":"Technical University of Munich,Munich,Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039133098","display_name":"Oliver Hayden","orcid":"https://orcid.org/0000-0002-2678-8663"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Hayden","raw_affiliation_strings":["Technical University of Munich,Munich,Germany"],"affiliations":[{"raw_affiliation_string":"Technical University of Munich,Munich,Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072502646","display_name":"Win Sen Kuan","orcid":"https://orcid.org/0000-0002-2134-7842"},"institutions":[{"id":"https://openalex.org/I4210146690","display_name":"National University Hospital","ror":"https://ror.org/04fp9fm22","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210146690"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Win Sen Kuan","raw_affiliation_strings":["National University Hospital,Singapore"],"affiliations":[{"raw_affiliation_string":"National University Hospital,Singapore","institution_ids":["https://openalex.org/I4210146690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022233834","display_name":"Wei Liu","orcid":"https://orcid.org/0000-0001-5386-3027"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wei Liu","raw_affiliation_strings":["Agency for Science, Technology and Research,Singapore"],"affiliations":[{"raw_affiliation_string":"Agency for Science, Technology and Research,Singapore","institution_ids":["https://openalex.org/I115228651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012832200","display_name":"John Tshon Yit Soong","orcid":null},"institutions":[{"id":"https://openalex.org/I4210146690","display_name":"National University Hospital","ror":"https://ror.org/04fp9fm22","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210146690"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"John Soong","raw_affiliation_strings":["National University Hospital,Singapore"],"affiliations":[{"raw_affiliation_string":"National University Hospital,Singapore","institution_ids":["https://openalex.org/I4210146690"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5101504866"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.222,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.57121696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"5610","last_page":"5615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11778","display_name":"Electrical and Bioimpedance Tomography","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11778","display_name":"Electrical and Bioimpedance Tomography","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13341","display_name":"Belt Conveyor Systems Engineering","score":0.9182999730110168,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/digital-holographic-microscopy","display_name":"Digital holographic microscopy","score":0.8530948758125305},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.683112382888794},{"id":"https://openalex.org/keywords/point-of-care","display_name":"Point of care","score":0.6727951765060425},{"id":"https://openalex.org/keywords/aggregate","display_name":"Aggregate (composite)","score":0.6321042776107788},{"id":"https://openalex.org/keywords/holography","display_name":"Holography","score":0.6224566698074341},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4753122925758362},{"id":"https://openalex.org/keywords/point","display_name":"Point (geometry)","score":0.4539681077003479},{"id":"https://openalex.org/keywords/optical-microscope","display_name":"Optical microscope","score":0.45265430212020874},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3844011127948761},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3152061104774475},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.19970661401748657},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1642104685306549},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.14310017228126526},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.13137510418891907},{"id":"https://openalex.org/keywords/scanning-electron-microscope","display_name":"Scanning electron microscope","score":0.11641398072242737},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10982504487037659},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.07275146245956421}],"concepts":[{"id":"https://openalex.org/C59994255","wikidata":"https://www.wikidata.org/wiki/Q5276092","display_name":"Digital holographic microscopy","level":3,"score":0.8530948758125305},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.683112382888794},{"id":"https://openalex.org/C51915194","wikidata":"https://www.wikidata.org/wiki/Q17075487","display_name":"Point of care","level":2,"score":0.6727951765060425},{"id":"https://openalex.org/C4679612","wikidata":"https://www.wikidata.org/wiki/Q866298","display_name":"Aggregate (composite)","level":2,"score":0.6321042776107788},{"id":"https://openalex.org/C187590223","wikidata":"https://www.wikidata.org/wiki/Q527628","display_name":"Holography","level":2,"score":0.6224566698074341},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4753122925758362},{"id":"https://openalex.org/C28719098","wikidata":"https://www.wikidata.org/wiki/Q44946","display_name":"Point (geometry)","level":2,"score":0.4539681077003479},{"id":"https://openalex.org/C77017923","wikidata":"https://www.wikidata.org/wiki/Q912313","display_name":"Optical microscope","level":3,"score":0.45265430212020874},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3844011127948761},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3152061104774475},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.19970661401748657},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1642104685306549},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14310017228126526},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13137510418891907},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.11641398072242737},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10982504487037659},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.07275146245956421},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10821749","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821749","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320338440","display_name":"HORIZON EUROPE Health","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W2011854883","https://openalex.org/W2080380084","https://openalex.org/W2085770918","https://openalex.org/W2302517508","https://openalex.org/W2907453767","https://openalex.org/W2946901414","https://openalex.org/W2963150697","https://openalex.org/W2980998394","https://openalex.org/W3012478585","https://openalex.org/W3082474906","https://openalex.org/W3215073785","https://openalex.org/W4200427314","https://openalex.org/W4224242128","https://openalex.org/W4382810129","https://openalex.org/W4386032930","https://openalex.org/W4386996067","https://openalex.org/W4388464572","https://openalex.org/W4393237778","https://openalex.org/W6990022686"],"related_works":["https://openalex.org/W2328609563","https://openalex.org/W4312527205","https://openalex.org/W2246931670","https://openalex.org/W4327547188","https://openalex.org/W2082754782","https://openalex.org/W2928460470","https://openalex.org/W4401390462","https://openalex.org/W746579726","https://openalex.org/W1966829612","https://openalex.org/W4389138632"],"abstract_inverted_index":{"In":[0],"the":[1,37,71,75,79,107,137,160,192],"acute":[2],"clinical":[3,53,92,144],"setting,":[4],"stratification":[5],"of":[6,41,60,78,96,121,143,163,175,194],"patients":[7],"presenting":[8],"with":[9,106,184],"fever":[10,42,176],"is":[11,99,171],"a":[12,133],"challenge":[13],"that":[14,159,174],"often":[15],"results":[16],"in":[17,91],"high":[18],"diagnostic":[19,89],"costs":[20],"and":[21,43,50,58,111,118,165,177,188,199],"inpatient":[22],"monitoring,":[23],"leading":[24],"to":[25,33,47,86],"substantial":[26],"resource":[27],"utilization.":[28],"Cellular":[29],"aggregation":[30],"patterns":[31,153,182],"promise":[32],"reveal":[34],"information":[35],"about":[36],"underlying":[38],"immunology":[39],"mechanisms":[40],"provide":[44],"new":[45],"biomarkers":[46,195],"facilitate":[48],"triage":[49,198],"diagnosis.":[51,200],"However,":[52],"utilization":[54],"requires":[55],"rapid":[56,141],"imaging":[57,84],"measurement":[59],"these":[61,64],"patterns,":[62],"currently":[63],"tools":[65],"are":[66],"unavailable.":[67],"This":[68],"study":[69],"introduces":[70],"YOLO-Graph":[72],"model":[73,148],"for":[74,129,196],"fast":[76],"analysis":[77,142],"aggregates":[80,167],"from":[81,168],"high-throughput":[82],"cellular":[83,122,151],"data,":[85],"enhance":[87],"early":[88,197],"capabilities":[90],"practice.":[93],"The":[94],"core":[95],"our":[97,146],"methodology":[98],"built":[100],"on":[101],"integrating":[102],"digital":[103],"holographic":[104],"microscopy":[105],"YOLOv8x-p2":[108],"neural":[109],"network":[110],"graph":[112],"model,":[113],"enabling":[114],"precise":[115],"morphological":[116],"detection":[117],"quantitative":[119],"assessment":[120],"aggregates.":[123],"Our":[124],"detector":[125],"achieved":[126],"91.14%":[127],"accuracy":[128],"aggregate":[130,152],"identification,":[131],"marking":[132],"13.92%":[134],"improvement":[135],"over":[136],"benchmark":[138],"pipeline.Using":[139],"this":[140],"samples,":[145],"YOLOGraph":[147],"identified":[149],"specific":[150,181],"during":[154],"immune":[155],"reactions.":[156],"We":[157],"showed":[158],"mean":[161],"value":[162],"platelet-platelet":[164],"leukocyte-platelet":[166],"healthy":[169],"controls":[170],"lower":[172],"than":[173],"pneumonia":[178],"patients.":[179],"Identifying":[180],"associated":[183],"clinically":[185],"important":[186],"diagnoses":[187],"outcomes":[189],"will":[190],"allow":[191],"development":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2025-12-23T23:11:35.936235","created_date":"2025-10-10T00:00:00"}
