{"id":"https://openalex.org/W4406271546","doi":"https://doi.org/10.1109/bibm62325.2024.10821731","title":"Learning Interpretable Continuous Representation for Alzheimer\u2019s Disease Classification","display_name":"Learning Interpretable Continuous Representation for Alzheimer\u2019s Disease Classification","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406271546","doi":"https://doi.org/10.1109/bibm62325.2024.10821731"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10821731","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821731","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087223934","display_name":"Menghui Zhou","orcid":"https://orcid.org/0000-0001-8973-418X"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Menghui Zhou","raw_affiliation_strings":["The University of Sheffield,Department of Computer Science,Sheffield,UK"],"affiliations":[{"raw_affiliation_string":"The University of Sheffield,Department of Computer Science,Sheffield,UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102902385","display_name":"Mingxia Wang","orcid":"https://orcid.org/0000-0003-2340-8941"},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingxia Wang","raw_affiliation_strings":["Yunnan University,National Pilot School of Software,Kunming,China"],"affiliations":[{"raw_affiliation_string":"Yunnan University,National Pilot School of Software,Kunming,China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100433635","display_name":"Yu Zhang","orcid":"https://orcid.org/0000-0002-8925-2284"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["The University of Sheffield,Department of Computer Science,Sheffield,UK"],"affiliations":[{"raw_affiliation_string":"The University of Sheffield,Department of Computer Science,Sheffield,UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049095825","display_name":"Zhipeng Yuan","orcid":"https://orcid.org/0000-0002-0333-524X"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zhipeng Yuan","raw_affiliation_strings":["The University of Sheffield,Department of Computer Science,Sheffield,UK"],"affiliations":[{"raw_affiliation_string":"The University of Sheffield,Department of Computer Science,Sheffield,UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030717108","display_name":"Vitaveska Lanfranchi","orcid":"https://orcid.org/0000-0003-3148-2535"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vitaveska Lanfranchi","raw_affiliation_strings":["The University of Sheffield,Department of Computer Science,Sheffield,UK"],"affiliations":[{"raw_affiliation_string":"The University of Sheffield,Department of Computer Science,Sheffield,UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008276130","display_name":"Po Yang","orcid":"https://orcid.org/0000-0002-8553-7127"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Po Yang","raw_affiliation_strings":["The University of Sheffield,Department of Computer Science,Sheffield,UK"],"affiliations":[{"raw_affiliation_string":"The University of Sheffield,Department of Computer Science,Sheffield,UK","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5087223934"],"corresponding_institution_ids":["https://openalex.org/I91136226"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23431184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"6545","last_page":"6552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.960099995136261,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.960099995136261,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6417602896690369},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6237287521362305},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.5863012671470642},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4330664277076721},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.3956161439418793},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3592635989189148},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3367667496204376},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16950345039367676},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.05412110686302185}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6417602896690369},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6237287521362305},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.5863012671470642},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4330664277076721},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.3956161439418793},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3592635989189148},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3367667496204376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16950345039367676},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05412110686302185},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10821731","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821731","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1849277567","https://openalex.org/W1989858256","https://openalex.org/W2061699647","https://openalex.org/W2078524519","https://openalex.org/W2094637188","https://openalex.org/W2098505831","https://openalex.org/W2164931791","https://openalex.org/W2167460663","https://openalex.org/W2194775991","https://openalex.org/W2194999895","https://openalex.org/W2566079294","https://openalex.org/W2580596898","https://openalex.org/W2593468621","https://openalex.org/W2774698027","https://openalex.org/W2783188875","https://openalex.org/W2790446188","https://openalex.org/W2883432928","https://openalex.org/W2890928570","https://openalex.org/W2906155095","https://openalex.org/W2919115771","https://openalex.org/W2964184826","https://openalex.org/W3022315685","https://openalex.org/W3174654335","https://openalex.org/W4206046172","https://openalex.org/W4241074797","https://openalex.org/W4294811409","https://openalex.org/W4296658109","https://openalex.org/W4306317074","https://openalex.org/W4312642389","https://openalex.org/W4382317568","https://openalex.org/W4387412063","https://openalex.org/W4394627530","https://openalex.org/W6637373629","https://openalex.org/W6749186005","https://openalex.org/W6780322082","https://openalex.org/W6803224836"],"related_works":["https://openalex.org/W2062195135","https://openalex.org/W2795079307","https://openalex.org/W2961085424","https://openalex.org/W2793058541","https://openalex.org/W1983629434","https://openalex.org/W2055929693","https://openalex.org/W4224009465","https://openalex.org/W4324271173","https://openalex.org/W1967645776","https://openalex.org/W2352227742"],"abstract_inverted_index":{"Alzheimer\u2019s":[0,113],"disease":[1,20],"(AD)":[2],"is":[3],"the":[4,16,38,50,60,68,112],"leading":[5],"cause":[6],"of":[7,41,71,106,136,165],"dementia":[8],"worldwide,":[9],"characterized":[10],"by":[11],"its":[12],"gradual":[13],"progression":[14],"and":[15,59,148],"subtle":[17],"variations":[18],"across":[19,98],"stages,":[21],"which":[22],"pose":[23],"significant":[24],"challenges":[25],"for":[26,162],"accurate":[27],"diagnosis.":[28],"While":[29],"deep":[30,72],"representation":[31,160],"learning":[32,73,137,161],"algorithms":[33],"have":[34],"shown":[35],"promise":[36],"in":[37,56,134],"early":[39],"detection":[40],"AD":[42,57,99],"using":[43,128],"MRI":[44,133],"data,":[45],"existing":[46],"approaches":[47],"often":[48],"overlook":[49],"meaningful":[51],"relationships":[52],"between":[53],"continuous":[54,96,138],"labels":[55],"progression,":[58],"learned":[61],"representations":[62,97],"frequently":[63],"lack":[64],"interpretability":[65],"due":[66],"to":[67,145,159],"black-box":[69],"nature":[70],"models.":[74],"To":[75],"address":[76],"these":[77],"limitations,":[78],"we":[79],"propose":[80],"ICReL":[81,121],"(Interpretable":[82],"Continuous":[83],"Representation":[84],"Learning),":[85],"a":[86,103,155],"novel":[87],"concept":[88],"based":[89],"on":[90,111],"coding":[91],"rate":[92],"principles":[93],"that":[94,120],"captures":[95],"stages":[100],"while":[101],"maintaining":[102],"high":[104],"degree":[105],"interpretability.":[107],"Extensive":[108],"experimental":[109],"results":[110],"Disease":[114],"Neuroimaging":[115],"Initiative":[116],"(ADNI)":[117],"dataset":[118],"demonstrate":[119],"not":[122],"only":[123],"outperforms":[124],"multiple":[125],"baseline":[126],"methods":[127],"2D":[129],"slice":[130],"or":[131],"3D":[132],"terms":[135],"representations,":[139],"but":[140],"also":[141],"exhibits":[142],"enhanced":[143],"robustness":[144],"label":[146],"corruption":[147],"superior":[149],"predictive":[150],"performance.":[151],"This":[152],"work":[153],"offers":[154],"new,":[156],"interpretable":[157],"approach":[158],"computer-aided":[163],"diagnosis":[164],"neurodegenerative":[166],"diseases.":[167]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}