{"id":"https://openalex.org/W4406259996","doi":"https://doi.org/10.1109/bibm62325.2024.10821719","title":"An Effective Tool for Differential Interaction Analysis in Single-Cell Hi-C Data","display_name":"An Effective Tool for Differential Interaction Analysis in Single-Cell Hi-C Data","publication_year":2024,"publication_date":"2024-12-03","ids":{"openalex":"https://openalex.org/W4406259996","doi":"https://doi.org/10.1109/bibm62325.2024.10821719"},"language":"en","primary_location":{"id":"doi:10.1109/bibm62325.2024.10821719","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821719","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074611035","display_name":"Yichao Zhao","orcid":"https://orcid.org/0000-0001-8784-5361"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yichao Zhao","raw_affiliation_strings":["Central South University,School of Computer Science and Engineering,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central South University,School of Computer Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044328870","display_name":"Ruiqing Zheng","orcid":"https://orcid.org/0000-0001-6372-6798"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruiqing Zheng","raw_affiliation_strings":["Central South University,School of Computer Science and Engineering,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central South University,School of Computer Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100725456","display_name":"Li Tang","orcid":"https://orcid.org/0000-0002-2930-0862"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Tang","raw_affiliation_strings":["Central South University,School of Computer Science and Engineering,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central South University,School of Computer Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112925021","display_name":"Pengzhen Jia","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengzhen Jia","raw_affiliation_strings":["Central South University,School of Computer Science and Engineering,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central South University,School of Computer Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040090704","display_name":"Min Li","orcid":"https://orcid.org/0000-0003-1330-2326"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["Central South University,School of Computer Science and Engineering,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central South University,School of Computer Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I139660479"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"264","last_page":"267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14509","display_name":"demographic modeling and climate adaptation","score":0.6869000196456909,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T14509","display_name":"demographic modeling and climate adaptation","score":0.6869000196456909,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13553","display_name":"Age of Information Optimization","score":0.6714000105857849,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10037","display_name":"Physics of Superconductivity and Magnetism","score":0.6657999753952026,"subfield":{"id":"https://openalex.org/subfields/3104","display_name":"Condensed Matter Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.596973180770874},{"id":"https://openalex.org/keywords/differential","display_name":"Differential (mechanical device)","score":0.4453500211238861},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1603083610534668}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.596973180770874},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.4453500211238861},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1603083610534668},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm62325.2024.10821719","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm62325.2024.10821719","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1965863160","https://openalex.org/W2114104545","https://openalex.org/W2146512944","https://openalex.org/W2551092411","https://openalex.org/W2599773520","https://openalex.org/W2731989040","https://openalex.org/W2768310712","https://openalex.org/W2783644856","https://openalex.org/W2898577086","https://openalex.org/W2965970564","https://openalex.org/W3131450268","https://openalex.org/W3158393751","https://openalex.org/W3193986928","https://openalex.org/W3194691506","https://openalex.org/W4313454972","https://openalex.org/W4379792586","https://openalex.org/W4386305466","https://openalex.org/W4386471322","https://openalex.org/W4387701182","https://openalex.org/W6753058790"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"The":[0,120],"three-dimensional":[1],"(3D)":[2],"genome":[3,47],"refers":[4],"to":[5,117],"exploring":[6],"the":[7,13,19,23,28,40,62,91],"spatial":[8],"arrangement":[9],"of":[10,22,44,59],"chromatins":[11],"within":[12],"cell":[14],"nucleus.":[15],"Analyzing":[16],"differential":[17,79],"interactions,":[18],"basic":[20],"units":[21],"3D":[24,46],"genome,":[25],"particularly":[26],"at":[27,124],"single-cell":[29,45,82],"level,":[30],"is":[31,122],"crucial":[32],"for":[33,64,77,101],"revealing":[34],"cell-type-specific":[35],"functions":[36],"and":[37,42,67,104,111],"states.":[38],"However,":[39],"sparsity":[41],"heterogeneity":[43],"data":[48,65],"pose":[49],"significant":[50],"challenges.":[51],"Although":[52],"existing":[53],"methods":[54],"offer":[55],"helpful":[56],"solutions,":[57],"most":[58],"them":[60],"lack":[61],"design":[63],"distribution":[66],"cell-specific":[68],"characteristics.":[69],"Here,":[70],"we":[71],"developed":[72],"a":[73],"new":[74],"method,":[75],"DISHIC,":[76],"identifying":[78],"interactions":[80],"in":[81],"high-throughput":[83],"Chromatin":[84],"Conformation":[85],"Capture":[86],"(scHi-C)":[87],"data.":[88],"Based":[89],"on":[90],"ZINB-WaVE":[92],"model,":[93],"DISHIC":[94],"independently":[95],"models":[96],"each":[97],"bin":[98],"pair,":[99],"accounting":[100],"both":[102],"bin-pair-level":[103],"cell-level":[105],"covariates.":[106],"We":[107],"validated":[108],"DISHIC's":[109],"effectiveness":[110,115],"demonstrated":[112],"its":[113],"enhanced":[114],"compared":[116],"other":[118],"methods.":[119],"code":[121],"available":[123],"https://github.com/zhaoyichao777/DISHIC.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}