{"id":"https://openalex.org/W4390971329","doi":"https://doi.org/10.1109/bibm58861.2023.10386003","title":"Simulations of the insulin-like growth factor receptor signaling pathway with randomly sampled parameters","display_name":"Simulations of the insulin-like growth factor receptor signaling pathway with randomly sampled parameters","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390971329","doi":"https://doi.org/10.1109/bibm58861.2023.10386003"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10386003","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10386003","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100395020","display_name":"Yan Yan","orcid":"https://orcid.org/0000-0001-6142-4251"},"institutions":[{"id":"https://openalex.org/I91125648","display_name":"Wuhan Institute of Technology","ror":"https://ror.org/04jcykh16","country_code":"CN","type":"education","lineage":["https://openalex.org/I91125648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Yan","raw_affiliation_strings":["Wuhan Institute of Technology,School of Mathematics and Physics,Wuhan,China","School of Mathematics and Physics, Wuhan Institute of Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan Institute of Technology,School of Mathematics and Physics,Wuhan,China","institution_ids":["https://openalex.org/I91125648"]},{"raw_affiliation_string":"School of Mathematics and Physics, Wuhan Institute of Technology, Wuhan, China","institution_ids":["https://openalex.org/I91125648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058742858","display_name":"Xinan Zhang","orcid":"https://orcid.org/0000-0001-8614-7975"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinan Zhang","raw_affiliation_strings":["Central China Normal University,School of Mathematics and Statistics,Wuhan,China","School of Mathematics and Statistics, Central China Normal University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University,School of Mathematics and Statistics,Wuhan,China","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"School of Mathematics and Statistics, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039097797","display_name":"Tianhai Tian","orcid":"https://orcid.org/0000-0001-6191-0209"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tianhai Tian","raw_affiliation_strings":["Monash University,School of Mathematics,Melbourne,VIC,Australia,3800"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash University,School of Mathematics,Melbourne,VIC,Australia,3800","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33334034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"3848","last_page":"3854"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9789000153541565,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9789000153541565,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9778000116348267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9635000228881836,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.6785291433334351},{"id":"https://openalex.org/keywords/pi3k/akt/mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.6005095839500427},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"Insulin receptor","score":0.5617349147796631},{"id":"https://openalex.org/keywords/protein-kinase-b","display_name":"Protein kinase B","score":0.5546023845672607},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5373451113700867},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-1-receptor","display_name":"Insulin-like growth factor 1 receptor","score":0.5142154693603516},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.4637743830680847},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4469814598560333},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.4147074222564697},{"id":"https://openalex.org/keywords/cell-signaling","display_name":"Cell signaling","score":0.4147071838378906},{"id":"https://openalex.org/keywords/growth-factor","display_name":"Growth factor","score":0.4117794632911682},{"id":"https://openalex.org/keywords/insulin","display_name":"Insulin","score":0.2500317692756653},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.17685839533805847},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"Insulin resistance","score":0.13117006421089172},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.09596383571624756}],"concepts":[{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6785291433334351},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6005095839500427},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.5617349147796631},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5546023845672607},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5373451113700867},{"id":"https://openalex.org/C144174609","wikidata":"https://www.wikidata.org/wiki/Q14901457","display_name":"Insulin-like growth factor 1 receptor","level":4,"score":0.5142154693603516},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4637743830680847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4469814598560333},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4147074222564697},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.4147071838378906},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4117794632911682},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2500317692756653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17685839533805847},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.13117006421089172},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09596383571624756}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10386003","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10386003","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1720790551","https://openalex.org/W1973239973","https://openalex.org/W1984804160","https://openalex.org/W1987195331","https://openalex.org/W1990587141","https://openalex.org/W1993147091","https://openalex.org/W1998203489","https://openalex.org/W2009928329","https://openalex.org/W2014096417","https://openalex.org/W2023887100","https://openalex.org/W2028062775","https://openalex.org/W2034188706","https://openalex.org/W2036606290","https://openalex.org/W2053460598","https://openalex.org/W2070658593","https://openalex.org/W2075161553","https://openalex.org/W2086262311","https://openalex.org/W2095306595","https://openalex.org/W2096595244","https://openalex.org/W2101744311","https://openalex.org/W2109169395","https://openalex.org/W2110808396","https://openalex.org/W2111789241","https://openalex.org/W2114108194","https://openalex.org/W2128718699","https://openalex.org/W2141361677","https://openalex.org/W2144370915","https://openalex.org/W2152185832","https://openalex.org/W2160985231","https://openalex.org/W2296294081","https://openalex.org/W2588000397","https://openalex.org/W2763635492","https://openalex.org/W2788776849","https://openalex.org/W2900732216","https://openalex.org/W2944383003","https://openalex.org/W3000279920","https://openalex.org/W3004706226","https://openalex.org/W3158001674","https://openalex.org/W3163058507","https://openalex.org/W3199815956","https://openalex.org/W3200117713","https://openalex.org/W4221106694","https://openalex.org/W4280488314","https://openalex.org/W4385956638"],"related_works":["https://openalex.org/W2783307588","https://openalex.org/W2041064076","https://openalex.org/W2080849305","https://openalex.org/W2323939539","https://openalex.org/W4390532131","https://openalex.org/W2055451075","https://openalex.org/W2076822732","https://openalex.org/W2992448946","https://openalex.org/W1986472720","https://openalex.org/W1983095166"],"abstract_inverted_index":{"The":[0],"insulin-like":[1],"growth":[2],"factor":[3],"(IGF)":[4],"receptor":[5],"signaling":[6,32,64,123],"pathway":[7,143,160,163,175,185],"plays":[8],"a":[9,24,102],"crucial":[10],"role":[11],"in":[12,18,37,74,94,141],"regulating":[13],"growth,":[14],"development,":[15],"and":[16,30,131,161,186],"metabolism":[17],"the":[19,42,59,68,77,91,121,129,142,151,157,170,179,182,197,204],"human":[20],"body.":[21],"It":[22],"encompasses":[23],"group":[25],"of":[26,44,62,70,153,173,199,206],"signalling":[27,72],"molecules,":[28],"receptors,":[29],"downstream":[31],"pathways":[33],"that":[34,89],"are":[35,167],"involved":[36],"various":[38,145],"physiological":[39],"processes.":[40],"Given":[41],"complexity":[43],"molecular":[45,92],"processes":[46],"within":[47],"this":[48,63,98],"pathway,":[49],"mathematical":[50],"models":[51],"have":[52,136,144],"emerged":[53],"as":[54,176,178],"potent":[55],"tools":[56],"for":[57,120,156],"dissecting":[58],"dynamic":[60,146],"behaviors":[61],"pathways.":[65],"To":[66],"address":[67],"heterogeneity":[69],"cellular":[71],"observed":[73],"single-cell":[75],"studies,":[76],"nonlinear":[78,103],"mixed-effects":[79,104],"model":[80,200],"has":[81],"been":[82],"used":[83],"recently":[84],"to":[85,117,195],"generate":[86,118],"different":[87,95,137],"simulations":[88,119],"represent":[90],"dynamics":[93,205],"cells.":[96],"In":[97],"study,":[99],"we":[100],"use":[101],"ordinary":[105,113],"differential":[106,114],"equation":[107,115],"model,":[108,116],"based":[109],"on":[110,203],"an":[111,192],"established":[112],"IGFR":[122],"pathway.":[124,188],"Simulations":[125],"shows":[126],"that,":[127],"when":[128],"AKT":[130,187],"mitogen-activated":[132],"protein":[133],"(MAP)":[134],"kinase":[135,159,184],"activities,":[138],"other":[139],"kinases":[140],"properties.":[147],"We":[148],"also":[149],"test":[150],"influence":[152],"two":[154],"inhibitors":[155],"MAP":[158,183],"PI3K/AKT":[162],"separately.":[164],"Simulation":[165],"results":[166],"consistent":[168],"with":[169],"regulatory":[171],"mechanisms":[172],"each":[174],"well":[177],"cross-talk":[180],"between":[181],"This":[189],"study":[190,196],"provides":[191],"alternative":[193],"method":[194],"functions":[198],"parameter":[201],"variations":[202],"complex":[207],"systems.":[208]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}