{"id":"https://openalex.org/W4390991988","doi":"https://doi.org/10.1109/bibm58861.2023.10386000","title":"PTDA-SWGCL: Predicting tRNA-Disease Associations using Supplementarily Weighted Graph Contrastive Learning","display_name":"PTDA-SWGCL: Predicting tRNA-Disease Associations using Supplementarily Weighted Graph Contrastive Learning","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390991988","doi":"https://doi.org/10.1109/bibm58861.2023.10386000"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10386000","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm58861.2023.10386000","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052229178","display_name":"Yuanpeng Zhang","orcid":"https://orcid.org/0000-0003-1736-3425"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuanpeng Zhang","raw_affiliation_strings":["Xinjiang University,School of Software,Urumqi,China","School of Software, Xinjiang University, Urumqi, China"],"affiliations":[{"raw_affiliation_string":"Xinjiang University,School of Software,Urumqi,China","institution_ids":["https://openalex.org/I96908189"]},{"raw_affiliation_string":"School of Software, Xinjiang University, Urumqi, China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002981402","display_name":"Yurong Qian","orcid":"https://orcid.org/0000-0001-6564-4745"},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yurong Qian","raw_affiliation_strings":["Xinjiang University,School of Software,Urumqi,China","School of Software, Xinjiang University, Urumqi, China"],"affiliations":[{"raw_affiliation_string":"Xinjiang University,School of Software,Urumqi,China","institution_ids":["https://openalex.org/I96908189"]},{"raw_affiliation_string":"School of Software, Xinjiang University, Urumqi, China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102884329","display_name":"Xiaojun Xiao","orcid":null},"institutions":[{"id":"https://openalex.org/I96908189","display_name":"Xinjiang University","ror":"https://ror.org/059gw8r13","country_code":"CN","type":"education","lineage":["https://openalex.org/I96908189"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojun Xiao","raw_affiliation_strings":["Xinjiang University,School of Software,Urumqi,China","School of Software, Xinjiang University, Urumqi, China"],"affiliations":[{"raw_affiliation_string":"Xinjiang University,School of Software,Urumqi,China","institution_ids":["https://openalex.org/I96908189"]},{"raw_affiliation_string":"School of Software, Xinjiang University, Urumqi, China","institution_ids":["https://openalex.org/I96908189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101610203","display_name":"Xiaowen Hu","orcid":"https://orcid.org/0000-0002-7339-3007"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowen Hu","raw_affiliation_strings":["Central South University,School of Computer Science and Engineering,Changsha,China","School of Computer Science and Engineering, Central South University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"Central South University,School of Computer Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015986813","display_name":"Zhijian Huang","orcid":"https://orcid.org/0000-0003-1601-3802"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijian Huang","raw_affiliation_strings":["Central South University,School of Computer Science and Engineering,Changsha,China","School of Computer Science and Engineering, Central South University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"Central South University,School of Computer Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113262237","display_name":"Lei Deng","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Deng","raw_affiliation_strings":["Central South University,School of Computer Science and Engineering,Changsha,China","School of Computer Science and Engineering, Central South University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"Central South University,School of Computer Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5052229178"],"corresponding_institution_ids":["https://openalex.org/I96908189"],"apc_list":null,"apc_paid":null,"fwci":0.3185,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.6545223,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"209","last_page":"214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transfer-rna","display_name":"Transfer RNA","score":0.6518207788467407},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6145080924034119},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.5392699241638184},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5093420743942261},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.4991295337677002},{"id":"https://openalex.org/keywords/semantic-similarity","display_name":"Semantic similarity","score":0.4934762716293335},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4844698905944824},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.47140052914619446},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.41788890957832336},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.41321074962615967},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.36531561613082886},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27218323945999146},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18492761254310608},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.18135347962379456},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.14741092920303345},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.145277738571167},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1167881190776825},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10834547877311707}],"concepts":[{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.6518207788467407},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6145080924034119},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.5392699241638184},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5093420743942261},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4991295337677002},{"id":"https://openalex.org/C130318100","wikidata":"https://www.wikidata.org/wiki/Q2268914","display_name":"Semantic similarity","level":2,"score":0.4934762716293335},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4844698905944824},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.47140052914619446},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41788890957832336},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.41321074962615967},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.36531561613082886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27218323945999146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18492761254310608},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.18135347962379456},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.14741092920303345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.145277738571167},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1167881190776825},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10834547877311707},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10386000","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm58861.2023.10386000","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1002725004","https://openalex.org/W2065506862","https://openalex.org/W2070493638","https://openalex.org/W2085906037","https://openalex.org/W2087064593","https://openalex.org/W2544883878","https://openalex.org/W2601934706","https://openalex.org/W2885318751","https://openalex.org/W2950847039","https://openalex.org/W2998496395","https://openalex.org/W3026092005","https://openalex.org/W3034492151","https://openalex.org/W3045200674","https://openalex.org/W3094605801","https://openalex.org/W3097173659","https://openalex.org/W3153325943","https://openalex.org/W3170286690","https://openalex.org/W3184643866","https://openalex.org/W3200290402","https://openalex.org/W4200432712","https://openalex.org/W4206711189","https://openalex.org/W4220710781","https://openalex.org/W4285803631","https://openalex.org/W4287812705","https://openalex.org/W4294811162","https://openalex.org/W4297891375","https://openalex.org/W4308871941","https://openalex.org/W4311995275","https://openalex.org/W6779961489"],"related_works":["https://openalex.org/W2040216736","https://openalex.org/W1998434095","https://openalex.org/W1979806605","https://openalex.org/W2075273261","https://openalex.org/W2905191830","https://openalex.org/W2939643004","https://openalex.org/W2114797768","https://openalex.org/W2380654781","https://openalex.org/W2176214140","https://openalex.org/W2516873349"],"abstract_inverted_index":{"tRNAs":[0,40],"play":[1],"a":[2,79],"pivotal":[3],"role":[4],"in":[5,24,50,160],"protein":[6],"synthesis":[7],"by":[8,137],"transporting":[9],"amino":[10],"acids":[11],"to":[12,16,34],"the":[13,67,126,138,142],"ribosome":[14],"according":[15],"mRNA":[17],"instructions.":[18],"These":[19],"molecules":[20],"are":[21,168],"essential":[22],"regulators":[23],"various":[25],"biological":[26],"processes,":[27],"and":[28,41,56,90,101,107,114,120,144,166],"their":[29],"dysregulation":[30],"is":[31,43,64,135],"closely":[32],"linked":[33],"human":[35],"diseases.":[36],"Predicting":[37],"associations":[38,63],"between":[39],"diseases":[42],"valuable":[44],"for":[45,82],"uncovering":[46],"biomarkers":[47],"that":[48,150],"aid":[49],"disease":[51,91,108,145],"prevention,":[52],"detection,":[53],"prognosis,":[54],"diagnosis,":[55],"treatment.":[57],"However,":[58],"experimental":[59],"validation":[60],"of":[61,69,141],"such":[62],"resource-intensive,":[65],"necessitating":[66],"development":[68],"robust":[70],"computational":[71],"methods.":[72,154],"In":[73],"this":[74,111],"study,":[75],"we":[76],"propose":[77],"PTDA-SWGCL,":[78],"novel":[80],"model":[81],"predicting":[83,161],"potential":[84],"tRNA-disease":[85,127,162],"associations.":[86,163],"PTDA-SWGCL":[87,151],"integrates":[88],"tRNA":[89,106,143],"similarity":[92,112],"information":[93,113],"derived":[94],"from":[95],"Gaussian":[96],"kernel":[97],"similarity,":[98,100],"sequence":[99],"semantic":[102],"similarity.":[103],"It":[104],"initializes":[105],"embeddings":[109],"using":[110],"refines":[115],"them":[116],"through":[117],"supplementarily":[118],"weight":[119],"graph":[121],"comparison":[122],"learning":[123],"training":[124],"on":[125],"association":[128,132],"graph.":[129],"The":[130,164],"final":[131],"pair":[133],"prediction":[134],"obtained":[136],"inner":[139],"product":[140],"embeddings.":[146],"Experimental":[147],"results":[148],"demonstrate":[149],"outperforms":[152],"state-of-the-art":[153],"Case":[155],"studies":[156],"confirm":[157],"its":[158],"effectiveness":[159],"code":[165],"data":[167],"available":[169],"at":[170],"https://github.com/ZYPssss/PTDA-SWGCL.":[171]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
