{"id":"https://openalex.org/W4390992414","doi":"https://doi.org/10.1109/bibm58861.2023.10385925","title":"KtreeBnIp: An Efficient Epistasis Mining Approach Using K-tree Optimizing Bayesian Network","display_name":"KtreeBnIp: An Efficient Epistasis Mining Approach Using K-tree Optimizing Bayesian Network","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390992414","doi":"https://doi.org/10.1109/bibm58861.2023.10385925"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10385925","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385925","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087894632","display_name":"Keqin Li","orcid":"https://orcid.org/0000-0001-5224-4048"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Keqin Li","raw_affiliation_strings":["Huazhong Agricultural University,Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics,Wuhan,China","Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics,Wuhan,China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100692891","display_name":"Xuan Yang","orcid":"https://orcid.org/0000-0002-6306-0110"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan Yang","raw_affiliation_strings":["Huazhong Agricultural University,Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics,Wuhan,China","Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics,Wuhan,China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048386963","display_name":"Ao Xie","orcid":"https://orcid.org/0000-0001-7735-5342"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ao Xie","raw_affiliation_strings":["Huazhong Agricultural University,Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics,Wuhan,China","Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics,Wuhan,China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083192739","display_name":"Yulong Kan","orcid":"https://orcid.org/0000-0002-9200-5161"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yulong Kan","raw_affiliation_strings":["Huazhong Agricultural University,Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics,Wuhan,China","Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics,Wuhan,China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100407798","display_name":"Xu Wang","orcid":"https://orcid.org/0000-0001-6476-0509"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Wang","raw_affiliation_strings":["Huazhong Agricultural University,Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics,Wuhan,China","Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics,Wuhan,China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101632353","display_name":"Junli Deng","orcid":"https://orcid.org/0000-0002-6034-7749"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junli Deng","raw_affiliation_strings":["Huazhong Agricultural University,Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics,Wuhan,China","Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics,Wuhan,China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016726574","display_name":"Jianxiao Liu","orcid":"https://orcid.org/0000-0002-9165-4012"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianxiao Liu","raw_affiliation_strings":["Huazhong Agricultural University,Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics,Wuhan,China","Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics,Wuhan,China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"Key Laboratory of Smart Farming for Agricultural Animals, Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China","institution_ids":["https://openalex.org/I204823248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5087894632"],"corresponding_institution_ids":["https://openalex.org/I204823248"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.40224742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":null,"first_page":"2817","last_page":"2824"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.9677000045776367,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.9677000045776367,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.9333999752998352,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.794588029384613},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6551072001457214},{"id":"https://openalex.org/keywords/bayesian-network","display_name":"Bayesian network","score":0.5574679374694824},{"id":"https://openalex.org/keywords/tree","display_name":"Tree (set theory)","score":0.5048261284828186},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.44431209564208984},{"id":"https://openalex.org/keywords/false-positive-rate","display_name":"False positive rate","score":0.4367341995239258},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3262574076652527},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.22185489535331726},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18421822786331177},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10777163505554199},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10476011037826538}],"concepts":[{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.794588029384613},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6551072001457214},{"id":"https://openalex.org/C33724603","wikidata":"https://www.wikidata.org/wiki/Q812540","display_name":"Bayesian network","level":2,"score":0.5574679374694824},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.5048261284828186},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.44431209564208984},{"id":"https://openalex.org/C95922358","wikidata":"https://www.wikidata.org/wiki/Q5432725","display_name":"False positive rate","level":2,"score":0.4367341995239258},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3262574076652527},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.22185489535331726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18421822786331177},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10777163505554199},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10476011037826538},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10385925","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385925","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324775","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1481655810","https://openalex.org/W1822695366","https://openalex.org/W1974510435","https://openalex.org/W1980771638","https://openalex.org/W2017489620","https://openalex.org/W2041170649","https://openalex.org/W2046918131","https://openalex.org/W2113082345","https://openalex.org/W2113784410","https://openalex.org/W2126964466","https://openalex.org/W2127599473","https://openalex.org/W2154572047","https://openalex.org/W2155781289","https://openalex.org/W2285056512","https://openalex.org/W2319197375","https://openalex.org/W2405013394","https://openalex.org/W2470566663","https://openalex.org/W2605140612","https://openalex.org/W2617467681","https://openalex.org/W2727539851","https://openalex.org/W2809656353","https://openalex.org/W2953267417","https://openalex.org/W2971147549","https://openalex.org/W3176466131","https://openalex.org/W6601905193"],"related_works":["https://openalex.org/W1547817677","https://openalex.org/W2615678788","https://openalex.org/W2023460495","https://openalex.org/W2109954095","https://openalex.org/W1967902778","https://openalex.org/W1981509636","https://openalex.org/W3139253026","https://openalex.org/W3035525216","https://openalex.org/W2157308673","https://openalex.org/W2099041096"],"abstract_inverted_index":{"Mining":[0],"the":[1,22,61,72,85,94,99,111,120,124,129,142,147,155,164],"epistatic":[2,156],"gene":[3],"loci":[4,67,157],"for":[5,206],"complex":[6],"diseases":[7],"is":[8,107],"an":[9],"important":[10],"research":[11],"topic":[12],"in":[13,96,202],"recent":[14],"years.":[15],"The":[16],"existing":[17],"epistasis":[18,47,167,186,207],"detection":[19,187],"methods":[20],"have":[21],"shortcomings":[23],"of":[24,65,149,204],"high":[25,29],"complexity,":[26],"low":[27],"efficiency,":[28],"false":[30,193],"positive":[31,194],"rate,":[32],"inability":[33],"to":[34,109,122,146,153],"deal":[35],"with":[36,163],"large-scale":[37,64,203],"genome-wide":[38],"data,":[39],"etc.":[40],"In":[41],"this":[42],"work,":[43],"we":[44],"propose":[45],"a":[46],"mining":[48,168],"method":[49],"which":[50],"using":[51,84,170],"k-tree":[52,62,79,134],"optimizing":[53,103],"Bayesian":[54,104],"network":[55,105,136,144],"(BN)":[56],"(KtreeBnIp).":[57],"Firstly,":[58],"it":[59,77,117,198],"constructs":[60],"including":[63],"SNP":[66],"and":[68,114,140,151,173,191],"phenotype":[69],"by":[70,83],"sampling":[71],"Dandelion":[73],"code":[74],"uniformly.":[75],"Then":[76],"decomposes":[78],"into":[80],"different":[81],"k-cliques":[82],"graph":[86],"decomposition":[87],"algorithm":[88],"based":[89],"on":[90],"neighbor":[91],"nodes.":[92],"For":[93],"nodes":[95],"each":[97],"k-clique,":[98],"integer":[100],"linear":[101],"programming":[102],"(ILPBN)":[106],"used":[108,201],"obtain":[110,123,154],"sub-network":[112],"quickly":[113],"accurately.":[115],"Finally,":[116],"merges":[118],"all":[119],"sub-networks":[121],"whole":[125],"network.":[126],"It":[127],"repeats":[128],"above":[130],"operations":[131],"(k-tree":[132],"generation,":[133],"decomposition,":[135],"generation)":[137],"several":[138],"times":[139],"gets":[141],"final":[143],"according":[145],"frequency":[148],"edges,":[150],"thus":[152],"affecting":[158],"phenotype.":[159],"We":[160],"compare":[161],"KtreeBnIp":[162,183],"current":[165],"popular":[166],"algorithms":[169],"both":[171],"simulated":[172],"real":[174],"age-related":[175],"macular":[176],"degeneration(AMD)":[177],"datasets.":[178],"Experiment":[179],"results":[180],"show":[181],"that":[182],"has":[184],"better":[185],"accuracy,":[188],"higher":[189],"F1-score,":[190],"lower":[192],"rate.":[195],"Most":[196],"importantly,":[197],"can":[199],"be":[200],"SNPs":[205],"detection.":[208]},"counts_by_year":[],"updated_date":"2025-12-23T23:11:35.936235","created_date":"2025-10-10T00:00:00"}
