{"id":"https://openalex.org/W4390971156","doi":"https://doi.org/10.1109/bibm58861.2023.10385895","title":"Establishing a Correlation of Clinical Characteristics with the Level of Tumor Mutation Burden in Urothelial Bladder Carcinoma","display_name":"Establishing a Correlation of Clinical Characteristics with the Level of Tumor Mutation Burden in Urothelial Bladder Carcinoma","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390971156","doi":"https://doi.org/10.1109/bibm58861.2023.10385895"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10385895","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385895","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032731443","display_name":"Lujain Alshomali","orcid":null},"institutions":[{"id":"https://openalex.org/I158749337","display_name":"Princess Sumaya University for Technology","ror":"https://ror.org/01jy46q10","country_code":"JO","type":"education","lineage":["https://openalex.org/I158749337"]}],"countries":["JO"],"is_corresponding":true,"raw_author_name":"Lujain Alshomali","raw_affiliation_strings":["Princess Sumaya University for Technology,Software Engineering Dept.,Amman,Jordan","Software Engineering Dept., Princess Sumaya University for Technology, Amman, Jordan"],"affiliations":[{"raw_affiliation_string":"Princess Sumaya University for Technology,Software Engineering Dept.,Amman,Jordan","institution_ids":["https://openalex.org/I158749337"]},{"raw_affiliation_string":"Software Engineering Dept., Princess Sumaya University for Technology, Amman, Jordan","institution_ids":["https://openalex.org/I158749337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093735877","display_name":"Rania Khorma","orcid":null},"institutions":[{"id":"https://openalex.org/I158749337","display_name":"Princess Sumaya University for Technology","ror":"https://ror.org/01jy46q10","country_code":"JO","type":"education","lineage":["https://openalex.org/I158749337"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Rania Khorma","raw_affiliation_strings":["Princess Sumaya University for Technology,Software Engineering Dept.,Amman,Jordan","Software Engineering Dept., Princess Sumaya University for Technology, Amman, Jordan"],"affiliations":[{"raw_affiliation_string":"Princess Sumaya University for Technology,Software Engineering Dept.,Amman,Jordan","institution_ids":["https://openalex.org/I158749337"]},{"raw_affiliation_string":"Software Engineering Dept., Princess Sumaya University for Technology, Amman, Jordan","institution_ids":["https://openalex.org/I158749337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024476272","display_name":"Abdullah Al-Refai","orcid":"https://orcid.org/0000-0002-1557-3982"},"institutions":[{"id":"https://openalex.org/I158749337","display_name":"Princess Sumaya University for Technology","ror":"https://ror.org/01jy46q10","country_code":"JO","type":"education","lineage":["https://openalex.org/I158749337"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Abdullah Al-Refai","raw_affiliation_strings":["Princess Sumaya University for Technology,Software Engineering Dept.,Amman,Jordan","Software Engineering Dept., Princess Sumaya University for Technology, Amman, Jordan"],"affiliations":[{"raw_affiliation_string":"Princess Sumaya University for Technology,Software Engineering Dept.,Amman,Jordan","institution_ids":["https://openalex.org/I158749337"]},{"raw_affiliation_string":"Software Engineering Dept., Princess Sumaya University for Technology, Amman, Jordan","institution_ids":["https://openalex.org/I158749337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009739727","display_name":"Abedalrhman Alkhateeb","orcid":"https://orcid.org/0000-0002-1751-7570"},"institutions":[{"id":"https://openalex.org/I72541430","display_name":"Lakehead University","ror":"https://ror.org/023p7mg82","country_code":"CA","type":"education","lineage":["https://openalex.org/I72541430"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Abedalrhman Alkhateeb","raw_affiliation_strings":["Lakehead University,Computer Science Dept.,Thunder Bay,Canada","Computer Science Dept., Lakehead University, Thunder Bay, Canada"],"affiliations":[{"raw_affiliation_string":"Lakehead University,Computer Science Dept.,Thunder Bay,Canada","institution_ids":["https://openalex.org/I72541430"]},{"raw_affiliation_string":"Computer Science Dept., Lakehead University, Thunder Bay, Canada","institution_ids":["https://openalex.org/I72541430"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5032731443"],"corresponding_institution_ids":["https://openalex.org/I158749337"],"apc_list":null,"apc_paid":null,"fwci":0.3268,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.66084404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"3998","last_page":"4001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.7462681531906128},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"Bladder cancer","score":0.6310750842094421},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.5824741125106812},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.5689016580581665},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.525127649307251},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5048449635505676},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5019369125366211},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"Immune checkpoint","score":0.49108076095581055},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.47148725390434265},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.4395981431007385},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20620307326316833},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11989593505859375},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.07601422071456909},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07436087727546692}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7462681531906128},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.6310750842094421},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.5824741125106812},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5689016580581665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.525127649307251},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5048449635505676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5019369125366211},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.49108076095581055},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.47148725390434265},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4395981431007385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20620307326316833},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11989593505859375},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07601422071456909},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07436087727546692},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10385895","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385895","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2096589896","https://openalex.org/W2104885590","https://openalex.org/W2133990480","https://openalex.org/W2600611927","https://openalex.org/W2635951006","https://openalex.org/W2794343662","https://openalex.org/W2922870792","https://openalex.org/W2949515538","https://openalex.org/W2966500633","https://openalex.org/W2978209487","https://openalex.org/W2979367866","https://openalex.org/W3096112873","https://openalex.org/W3128646645","https://openalex.org/W3164167181","https://openalex.org/W4213428886"],"related_works":["https://openalex.org/W2533581028","https://openalex.org/W2898558914","https://openalex.org/W4237262135","https://openalex.org/W2090817358","https://openalex.org/W3127976301","https://openalex.org/W2111160383","https://openalex.org/W2056890439","https://openalex.org/W2981899172","https://openalex.org/W1522132782","https://openalex.org/W2261933510"],"abstract_inverted_index":{"Bladder":[0],"cancer":[1,56],"is":[2,35,60],"a":[3,36,80,125],"complex":[4],"disease":[5],"and":[6,43,130,147,152,163,171,185],"one":[7],"of":[8,13,57,65,83,137,165,173,177,180,192],"the":[9,54,88,93,135,156,174,178,189,193],"most":[10],"lethal":[11],"types":[12],"cancer.":[14],"Recently,":[15],"some":[16],"malignancies,":[17],"including":[18],"bladder":[19,55],"carcinomas,":[20],"have":[21],"shown":[22],"better":[23],"results":[24],"with":[25,68,77,79,134],"immunotherapy":[26,44],"using":[27],"immune":[28],"checkpoint":[29],"inhibitors.":[30],"Tumor":[31],"mutational":[32],"burden":[33,73,91],"(TMB)":[34,74],"potential":[37],"biomarker":[38],"for":[39,87],"predicting":[40],"tumor":[41,71],"behavior":[42],"response":[45],"as":[46],"an":[47,69],"outcome.":[48],"Publicly":[49],"available":[50],"clinical":[51,66,128,161,190],"data":[52],"from":[53],"TCGA":[58],"project":[59],"used":[61,111,122],"to":[62,112,123,160,183],"analyze":[63],"correlations":[64],"variables":[67,129,162],"increased":[70],"mutation":[72,90],"number":[75,82],"compared":[76,133],"those":[78],"lower":[81],"mutations.":[84],"The":[85,104,116],"threshold":[86],"high":[89],"in":[92],"analysis":[94],"was":[95,110,121,143],"set":[96],"at":[97],"10":[98],"mutations":[99],"(Mut)":[100],"per":[101],"Megabase":[102],"(Mb).":[103],"Chi-Square":[105,117],"test":[106],"(\u03c7<inf":[107],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[108],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</inf>)":[109],"compare":[113],"categorical":[114],"data.":[115],"\"Best":[118],"first\"":[119],"method":[120,159],"find":[124],"correlation":[126,142],"between":[127,145],"TMB,":[131,181],"then":[132],"p-value":[136],"significance":[138],"(p<0.05).":[139],"A":[140],"significant":[141],"found":[144],"TMB":[146],"Race,":[148],"Neoplasm":[149],"Histologic":[150],"Grade,":[151],"gender":[153],"when":[154],"applying":[155],"Best":[157],"First/Chi-Square":[158],"level":[164,179],"TMB.":[166],"This":[167],"enables":[168],"further":[169],"investigation":[170],"application":[172],"prediction":[175],"models":[176],"responsiveness":[182],"immunotherapy,":[184],"prognosis":[186],"based":[187],"on":[188],"features":[191],"patients.":[194]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2025-12-25T23:11:45.687758","created_date":"2025-10-10T00:00:00"}
