{"id":"https://openalex.org/W4390992360","doi":"https://doi.org/10.1109/bibm58861.2023.10385892","title":"A Heterogeneous Ranking Contrastive Learning Method for Drug-Target Interaction Prediction","display_name":"A Heterogeneous Ranking Contrastive Learning Method for Drug-Target Interaction Prediction","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390992360","doi":"https://doi.org/10.1109/bibm58861.2023.10385892"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10385892","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385892","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068706606","display_name":"Desheng Kong","orcid":"https://orcid.org/0000-0002-7339-7593"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Desheng Kong","raw_affiliation_strings":["Nankai University,Collage of Software,TianJin,China","Collage of Software, Nankai University, TianJin, China"],"affiliations":[{"raw_affiliation_string":"Nankai University,Collage of Software,TianJin,China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Collage of Software, Nankai University, TianJin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101804966","display_name":"Jin Xu","orcid":"https://orcid.org/0000-0001-9372-5681"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Jin","raw_affiliation_strings":["Nankai University,Collage of Software,TianJin,China","Collage of Software, Nankai University, TianJin, China"],"affiliations":[{"raw_affiliation_string":"Nankai University,Collage of Software,TianJin,China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Collage of Software, Nankai University, TianJin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086445905","display_name":"Maoqiang Xie","orcid":"https://orcid.org/0000-0003-1010-0534"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"MaoQiang Xie","raw_affiliation_strings":["Nankai University,Collage of Software,TianJin,China","Collage of Software, Nankai University, TianJin, China"],"affiliations":[{"raw_affiliation_string":"Nankai University,Collage of Software,TianJin,China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Collage of Software, Nankai University, TianJin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100448076","display_name":"Mingming Liu","orcid":"https://orcid.org/0000-0002-6861-5824"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"MingMing Liu","raw_affiliation_strings":["Nankai University,Collage of Software,TianJin,China","Collage of Software, Nankai University, TianJin, China"],"affiliations":[{"raw_affiliation_string":"Nankai University,Collage of Software,TianJin,China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Collage of Software, Nankai University, TianJin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058722514","display_name":"Yanhao Li","orcid":"https://orcid.org/0000-0003-1749-2032"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhao Li","raw_affiliation_strings":["Nankai University,Collage of Software,TianJin,China","Collage of Software, Nankai University, TianJin, China"],"affiliations":[{"raw_affiliation_string":"Nankai University,Collage of Software,TianJin,China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Collage of Software, Nankai University, TianJin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100904464","display_name":"Jingjing He","orcid":"https://orcid.org/0009-0005-0158-4532"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjing He","raw_affiliation_strings":["Nankai University,Collage of Software,TianJin,China","Collage of Software, Nankai University, TianJin, China"],"affiliations":[{"raw_affiliation_string":"Nankai University,Collage of Software,TianJin,China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Collage of Software, Nankai University, TianJin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100627106","display_name":"Hao Shi","orcid":"https://orcid.org/0000-0003-0184-2245"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Shi","raw_affiliation_strings":["Nankai University,Collage of Software,TianJin,China","Collage of Software, Nankai University, TianJin, China"],"affiliations":[{"raw_affiliation_string":"Nankai University,Collage of Software,TianJin,China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Collage of Software, Nankai University, TianJin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005983505","display_name":"Yiran Wan","orcid":null},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiran Wan","raw_affiliation_strings":["Nankai University,Collage of Software,TianJin,China","Collage of Software, Nankai University, TianJin, China"],"affiliations":[{"raw_affiliation_string":"Nankai University,Collage of Software,TianJin,China","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Collage of Software, Nankai University, TianJin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101082924","display_name":"Yalou Huang","orcid":"https://orcid.org/0000-0002-6573-1854"},"institutions":[{"id":"https://openalex.org/I4210112130","display_name":"Tianjin International Joint Academy of Biomedicine","ror":"https://ror.org/01v11cc68","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210112130"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yalou Huang","raw_affiliation_strings":["TianJin International Joint Academy of Biomedicine,TianJin,China","TianJin International Joint Academy of Biomedicine, TianJin, China"],"affiliations":[{"raw_affiliation_string":"TianJin International Joint Academy of Biomedicine,TianJin,China","institution_ids":["https://openalex.org/I4210112130"]},{"raw_affiliation_string":"TianJin International Joint Academy of Biomedicine, TianJin, China","institution_ids":["https://openalex.org/I4210112130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102743275","display_name":"Weiwei Yang","orcid":"https://orcid.org/0000-0002-0377-2626"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weiwei Yang","raw_affiliation_strings":["China Electronics Divital Innovation"],"affiliations":[{"raw_affiliation_string":"China Electronics Divital Innovation","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5068706606"],"corresponding_institution_ids":["https://openalex.org/I205237279"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26770985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":null,"first_page":"237","last_page":"240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11273","display_name":"Advanced Graph Neural Networks","score":0.9257000088691711,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7526178359985352},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5946484804153442},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5632013082504272},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5593307018280029},{"id":"https://openalex.org/keywords/generalization","display_name":"Generalization","score":0.5215739607810974},{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.4716067910194397},{"id":"https://openalex.org/keywords/consistency","display_name":"Consistency (knowledge bases)","score":0.43216848373413086},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.3332853317260742},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.23627883195877075},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.12576133012771606}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7526178359985352},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5946484804153442},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5632013082504272},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5593307018280029},{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.5215739607810974},{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.4716067910194397},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.43216848373413086},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.3332853317260742},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.23627883195877075},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12576133012771606},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10385892","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385892","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W2139516171","https://openalex.org/W2187089797","https://openalex.org/W2753953057","https://openalex.org/W2767891136","https://openalex.org/W2896900946","https://openalex.org/W2912358215","https://openalex.org/W3021338900","https://openalex.org/W3126516421","https://openalex.org/W3133638358","https://openalex.org/W3216881118","https://openalex.org/W4220796987","https://openalex.org/W4296044354"],"related_works":["https://openalex.org/W3162204513","https://openalex.org/W2371138613","https://openalex.org/W2048963458","https://openalex.org/W43109613","https://openalex.org/W2359952343","https://openalex.org/W2188500270","https://openalex.org/W2239445980","https://openalex.org/W2303858293","https://openalex.org/W2080152487","https://openalex.org/W1546381263"],"abstract_inverted_index":{"Recently,":[0],"with":[1],"the":[2,73,108,117,123,136,144],"in-depth":[3],"study":[4],"of":[5,44,126,146],"biological":[6,49,113],"network":[7],"structures,":[8],"methods":[9],"such":[10],"as":[11,54],"graph":[12,16,102],"neural":[13],"networks":[14],"and":[15,23,81,132,161,167],"contrastive":[17,52,67,91,138],"learning":[18,53,68,92,139],"have":[19,69],"attracted":[20],"significant":[21,71],"attention":[22],"demonstrated":[24],"notable":[25],"advantages":[26],"in":[27,47,111,122],"DTI":[28,96,147],"prediction.":[29],"Nevertheless,":[30],"it":[31,162],"remains":[32],"a":[33,41,88],"challenging":[34],"task":[35],"that":[36,152],"predicting":[37],"new":[38],"DTIs":[39],"by":[40,85],"small":[42],"number":[43],"known":[45],"data":[46],"heterogeneous":[48,89,112,137],"networks.":[50,114],"Graph":[51],"an":[55],"effective":[56],"method":[57,93],"to":[58,106,128,142],"solute":[59],"this":[60,86],"issue":[61],"has":[62],"been":[63],"proposed":[64],"recently.":[65],"Although":[66],"shown":[70],"advantages,":[72],"objective":[74],"function":[75],"heavily":[76],"relies":[77],"on":[78,158],"unbiased":[79],"positive":[80,131],"negative":[82,133],"samples.":[83],"Inspired":[84],"issue,":[87],"ranking":[90,124],"(HRCL-DTI)":[94],"for":[95,135],"prediction":[97,118],"is":[98],"proposed.":[99],"Specifically,":[100],"multiple":[101,159],"encoders":[103],"are":[104,120],"employed":[105],"capture":[107],"topological":[109],"relationships":[110],"After":[115],"that,":[116],"scores":[119],"calculated":[121],"module":[125],"HRCL-DTI":[127,153],"select":[129],"reliable":[130],"samples":[134],"module,":[140],"aiming":[141],"enhance":[143],"consistency":[145],"representations.":[148],"Experimental":[149],"results":[150],"demonstrate":[151],"outperforms":[154],"existing":[155],"stateof-the-art":[156],"baselines":[157],"datasets":[160],"possesses":[163],"strong":[164],"generalization":[165],"ability":[166],"practical":[168],"effectiveness.":[169]},"counts_by_year":[],"updated_date":"2025-12-25T23:11:45.687758","created_date":"2025-10-10T00:00:00"}