{"id":"https://openalex.org/W4390971077","doi":"https://doi.org/10.1109/bibm58861.2023.10385887","title":"A Novel Drug-Drug Interaction Prediction Model Based on Line Subgraph Generation Strategy","display_name":"A Novel Drug-Drug Interaction Prediction Model Based on Line Subgraph Generation Strategy","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390971077","doi":"https://doi.org/10.1109/bibm58861.2023.10385887"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10385887","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385887","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088900710","display_name":"Tian Bai","orcid":"https://orcid.org/0000-0001-8060-4725"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210134929","display_name":"Jilin Province Science and Technology Department","ror":"https://ror.org/049x38272","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210134929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Bai","raw_affiliation_strings":["Jilin University,College of Computer Science and Technology,Changchun,China","College of Computer Science and Technology, Jilin University, Changchun, China","Key Laboratory of Symbolic Computation and Knowledge Engineering, Ministry of Education, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin University,College of Computer Science and Technology,Changchun,China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210134929"]},{"raw_affiliation_string":"College of Computer Science and Technology, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210134929"]},{"raw_affiliation_string":"Key Laboratory of Symbolic Computation and Knowledge Engineering, Ministry of Education, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100675408","display_name":"Chu Li","orcid":"https://orcid.org/0009-0003-7612-6224"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chu Li","raw_affiliation_strings":["Jilin University,College of Software,Changchun,China","College of Software, Jilin University, Changchun, China","Key Laboratory of Symbolic Computation and Knowledge Engineering, Ministry of Education, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin University,College of Software,Changchun,China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"College of Software, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Key Laboratory of Symbolic Computation and Knowledge Engineering, Ministry of Education, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101892442","display_name":"Xinyue Peng","orcid":"https://orcid.org/0000-0001-6386-2140"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I49232843","display_name":"Changchun University","ror":"https://ror.org/02an57k10","country_code":"CN","type":"education","lineage":["https://openalex.org/I49232843"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyue Peng","raw_affiliation_strings":["Jilin University,School of Nursing,Changchun,China","School of Nursing, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin University,School of Nursing,Changchun,China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I49232843"]},{"raw_affiliation_string":"School of Nursing, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025700414","display_name":"Haotian Guan","orcid":null},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210134929","display_name":"Jilin Province Science and Technology Department","ror":"https://ror.org/049x38272","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210134929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haotian Guan","raw_affiliation_strings":["Jilin University,College of Computer Science and Technology,Changchun,China","College of Computer Science and Technology, Jilin University, Changchun, China","Key Laboratory of Symbolic Computation and Knowledge Engineering, Ministry of Education, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin University,College of Computer Science and Technology,Changchun,China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210134929"]},{"raw_affiliation_string":"College of Computer Science and Technology, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210134929"]},{"raw_affiliation_string":"Key Laboratory of Symbolic Computation and Knowledge Engineering, Ministry of Education, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012016681","display_name":"Zefan Zhang","orcid":"https://orcid.org/0000-0001-5627-050X"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210134929","display_name":"Jilin Province Science and Technology Department","ror":"https://ror.org/049x38272","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210134929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zefan Zhang","raw_affiliation_strings":["Jilin University,College of Computer Science and Technology,Changchun,China","College of Computer Science and Technology, Jilin University, Changchun, China","Key Laboratory of Symbolic Computation and Knowledge Engineering, Ministry of Education, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin University,College of Computer Science and Technology,Changchun,China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210134929"]},{"raw_affiliation_string":"College of Computer Science and Technology, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210134929"]},{"raw_affiliation_string":"Key Laboratory of Symbolic Computation and Knowledge Engineering, Ministry of Education, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089534072","display_name":"Guishen Wang","orcid":"https://orcid.org/0000-0001-6039-9285"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210164189","display_name":"Jilin International Studies University","ror":"https://ror.org/05mvcw862","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210164189"]},{"id":"https://openalex.org/I4385474403","display_name":"Changchun University of Technology","ror":"https://ror.org/052pakb34","country_code":"CN","type":"education","lineage":["https://openalex.org/I4385474403"]},{"id":"https://openalex.org/I49232843","display_name":"Changchun University","ror":"https://ror.org/02an57k10","country_code":"CN","type":"education","lineage":["https://openalex.org/I49232843"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guishen Wang","raw_affiliation_strings":["Jilin University,School of Life Sciences,Changchun,China","College of Computer Science and Engineering, Changchun University of Technology, Changchun, China","School of Life Sciences, Jilin University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin University,School of Life Sciences,Changchun,China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210164189","https://openalex.org/I49232843"]},{"raw_affiliation_string":"College of Computer Science and Engineering, Changchun University of Technology, Changchun, China","institution_ids":["https://openalex.org/I4385474403"]},{"raw_affiliation_string":"School of Life Sciences, Jilin University, Changchun, China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4167,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.82365029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"153","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9793999791145325,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.911300003528595,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6145546436309814},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.4957643449306488},{"id":"https://openalex.org/keywords/cosine-similarity","display_name":"Cosine similarity","score":0.4596213400363922},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.4426473379135132},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4170013666152954},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.41390809416770935},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.33043110370635986},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.29183080792427063},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08549121022224426}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6145546436309814},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.4957643449306488},{"id":"https://openalex.org/C2780762811","wikidata":"https://www.wikidata.org/wiki/Q1784941","display_name":"Cosine similarity","level":3,"score":0.4596213400363922},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.4426473379135132},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4170013666152954},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41390809416770935},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.33043110370635986},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.29183080792427063},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08549121022224426},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10385887","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385887","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W2007954020","https://openalex.org/W2187089797","https://openalex.org/W2767891136","https://openalex.org/W2992586577","https://openalex.org/W2997578645","https://openalex.org/W3024894285","https://openalex.org/W3039265083","https://openalex.org/W3094497296","https://openalex.org/W3156650687","https://openalex.org/W3157889929","https://openalex.org/W3183966140","https://openalex.org/W3205082786","https://openalex.org/W3206046197","https://openalex.org/W3213715512","https://openalex.org/W4200227922","https://openalex.org/W4205463297","https://openalex.org/W4228996904","https://openalex.org/W4230270846","https://openalex.org/W4231449374","https://openalex.org/W4285794944","https://openalex.org/W4294558607","https://openalex.org/W4313405519","https://openalex.org/W4313525564","https://openalex.org/W4327722639","https://openalex.org/W4379016428","https://openalex.org/W4382239162","https://openalex.org/W6726873649","https://openalex.org/W6738964360"],"related_works":["https://openalex.org/W126212742","https://openalex.org/W4206379684","https://openalex.org/W4248119222","https://openalex.org/W2111998194","https://openalex.org/W2053824000","https://openalex.org/W3138464402","https://openalex.org/W2366105490","https://openalex.org/W2580680567","https://openalex.org/W4390349266","https://openalex.org/W2360571912"],"abstract_inverted_index":{"Drug-Drug":[0],"Interaction":[1],"(DDI)":[2],"prediction":[3,19,131],"task":[4,132,137],"is":[5],"helpful":[6],"for":[7,138],"better-understanding":[8],"drugs.":[9],"In":[10],"this":[11],"paper,":[12],"we":[13,57,85,104,127,155],"propose":[14,58,105],"a":[15,59,106,134,157],"novel":[16],"drug-drug":[17],"interaction":[18],"model":[20,32,167],"based":[21],"on":[22],"line":[23,44,87,107,124,140,163,184],"subgraph":[24,45,108,141,185],"generation":[25,46,109,186],"strategy,":[26,47],"named":[27],"DDI-LSG":[28,31,83,153,166],"model.":[29],"Our":[30,165],"consists":[33],"of":[34,81,142,151],"three":[35],"main":[36],"parts":[37],"which":[38],"include":[39],"drug":[40,65,68,94],"relation":[41,69,114],"graph":[42,70,88],"construction,":[43],"and":[48,76,115,183],"graph-level":[49,135,158],"classification.":[50],"To":[51,73],"consider":[52,74],"more":[53],"relationships":[54],"among":[55],"drugs,":[56],"node":[60,113,179],"feature-enhancing":[61],"method":[62,182],"to":[63,90,111,160],"encode":[64],"features":[66],"in":[67,122,147],"construction":[71],"process.":[72],"drugs":[75],"DDI":[77,92,121,130],"as":[78],"equivalent":[79],"factors":[80],"our":[82,152],"model,":[84,154],"introduce":[86],"transformation":[89],"integrate":[91],"with":[93,101],"feature":[95,180],"enhancing":[96,181],"vector.":[97],"Combining":[98],"Jaccard":[99],"similarity":[100],"cosine":[102],"similarity,":[103],"strategy":[110],"evaluate":[112],"extract":[116],"key":[117],"structures":[118],"around":[119],"target":[120,144],"the":[123,129,139,143,148,162,178],"graph.":[125],"Then,":[126],"reformulate":[128],"into":[133],"classification":[136],"DDI.":[145],"Therefore,":[146],"final":[149],"part":[150],"use":[156],"classifier":[159],"classify":[161],"subgraphs.":[164],"outperforms":[168],"better":[169],"experiment":[170],"results":[171,175],"than":[172],"baselines.":[173],"Ablation":[174],"have":[176],"validated":[177],"strategy.":[187]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}