{"id":"https://openalex.org/W4390992003","doi":"https://doi.org/10.1109/bibm58861.2023.10385879","title":"Counterfactual Inference-based Data Augmentation for Drug-side effect Associations Prediction","display_name":"Counterfactual Inference-based Data Augmentation for Drug-side effect Associations Prediction","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390992003","doi":"https://doi.org/10.1109/bibm58861.2023.10385879"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10385879","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm58861.2023.10385879","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059693690","display_name":"Wenjie Yao","orcid":"https://orcid.org/0000-0002-3165-8724"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjie Yao","raw_affiliation_strings":["Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,China,430079","School of Computer, Central China Normal University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,China,430079","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079405950","display_name":"Weizhong Zhao","orcid":"https://orcid.org/0000-0001-8552-6084"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weizhong Zhao","raw_affiliation_strings":["Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,China,430079","National Language Resources Monitoring and Research Center for Network Media, Central China Normal University, Wuhan, China","School of Computer, Central China Normal University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,China,430079","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"National Language Resources Monitoring and Research Center for Network Media, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100734038","display_name":"Xiaowei Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I102401767","display_name":"University of Arkansas at Little Rock","ror":"https://ror.org/04fttyv97","country_code":"US","type":"education","lineage":["https://openalex.org/I102401767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaowei Xu","raw_affiliation_strings":["University of Arkansas at Little Rock,Department of Information Science,Little Rock,AR,USA,72204"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas at Little Rock,Department of Information Science,Little Rock,AR,USA,72204","institution_ids":["https://openalex.org/I102401767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113706284","display_name":"Xingpeng Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingpeng Jiang","raw_affiliation_strings":["Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,China,430079","School of Computer, Central China Normal University, Wuhan, China","National Language Resources Monitoring and Research Center for Network Media, Central China Normal University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,China,430079","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"National Language Resources Monitoring and Research Center for Network Media, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101496385","display_name":"Xianjun Shen","orcid":"https://orcid.org/0000-0001-5714-8848"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianjun Shen","raw_affiliation_strings":["Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,China,430079","School of Computer, Central China Normal University, Wuhan, China","National Language Resources Monitoring and Research Center for Network Media, Central China Normal University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,China,430079","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"National Language Resources Monitoring and Research Center for Network Media, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102010131","display_name":"Tingting He","orcid":"https://orcid.org/0000-0001-7523-6550"},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting He","raw_affiliation_strings":["Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,China,430079","School of Computer, Central China Normal University, Wuhan, China","National Language Resources Monitoring and Research Center for Network Media, Central China Normal University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University,Hubei Provincial Key Laboratory of Artificial Intelligence and Smart Learning,Wuhan,China,430079","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"School of Computer, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"National Language Resources Monitoring and Research Center for Network Media, Central China Normal University, Wuhan, China","institution_ids":["https://openalex.org/I40963666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1643","last_page":"1648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/counterfactual-thinking","display_name":"Counterfactual thinking","score":0.8697068691253662},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6563401818275452},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6290278434753418},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.47846317291259766},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3563233017921448},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.3494664132595062},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.34139591455459595},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3204602599143982},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.17180216312408447},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16846421360969543},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14410319924354553},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.11540713906288147}],"concepts":[{"id":"https://openalex.org/C108650721","wikidata":"https://www.wikidata.org/wiki/Q1783253","display_name":"Counterfactual thinking","level":2,"score":0.8697068691253662},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6563401818275452},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6290278434753418},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.47846317291259766},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3563233017921448},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.3494664132595062},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.34139591455459595},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3204602599143982},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.17180216312408447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16846421360969543},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14410319924354553},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11540713906288147},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10385879","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm58861.2023.10385879","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322186","display_name":"Natural Science Foundation of Hubei Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1522301498","https://openalex.org/W1977556410","https://openalex.org/W2003668590","https://openalex.org/W2060240021","https://openalex.org/W2141245797","https://openalex.org/W2166467489","https://openalex.org/W2461480626","https://openalex.org/W2611846802","https://openalex.org/W2753953057","https://openalex.org/W2789789321","https://openalex.org/W2897753544","https://openalex.org/W3012365916","https://openalex.org/W3014239097","https://openalex.org/W3033039844","https://openalex.org/W3043750334","https://openalex.org/W3093811011","https://openalex.org/W3095602948","https://openalex.org/W3095746859","https://openalex.org/W3135755067","https://openalex.org/W3154503084","https://openalex.org/W3174291985","https://openalex.org/W4225873739","https://openalex.org/W4313413399","https://openalex.org/W6631190155","https://openalex.org/W6719103970","https://openalex.org/W6779940601","https://openalex.org/W6784694379"],"related_works":["https://openalex.org/W3201448254","https://openalex.org/W4286970243","https://openalex.org/W2066431708","https://openalex.org/W4384133558","https://openalex.org/W3025615835","https://openalex.org/W173210993","https://openalex.org/W2390660599","https://openalex.org/W3028847759","https://openalex.org/W2393688264","https://openalex.org/W3170174360"],"abstract_inverted_index":{"Detecting":[0],"drug":[1],"side":[2,150],"effects":[3],"is":[4,107],"crucial":[5],"in":[6,36],"development":[7],"of":[8,43,79,147,155,163],"drugs.":[9],"As":[10],"publicly":[11],"available":[12],"biomedical":[13,38,112],"data":[14,44,57,96,113,167],"expands,":[15],"researchers":[16],"have":[17,32,60],"devised":[18],"numerous":[19],"computational":[20],"methods":[21,59],"for":[22,50,169],"predicting":[23],"drug-side":[24],"effect":[25],"associations":[26],"(DSAs).":[27],"Among":[28],"these,":[29],"network-based":[30],"approaches":[31],"gained":[33],"significant":[34,48],"attention":[35],"the":[37,41,65,73,77,84,120,153,161],"field.":[39],"However,":[40],"challenge":[42],"scarcity":[45],"poses":[46],"a":[47,93,124,138],"hurdle":[49],"existing":[51],"DSAs":[52,170],"prediction":[53,154],"models.":[54],"While":[55],"various":[56],"augmentation":[58,97,168],"been":[61],"created":[62],"to":[63,72,99,122,143],"solve":[64],"proble,":[66],"most":[67],"rely":[68],"on":[69,119],"random":[70],"alterations":[71],"original":[74],"networks,":[75],"neglecting":[76],"causality":[78],"DSAs\u2019":[80],"existence,":[81],"thus":[82],"impacting":[83],"predictive":[85],"performance":[86],"negatively.":[87],"In":[88],"this":[89,164],"paper,":[90],"we":[91,136],"introduce":[92],"counterfactual":[94,125,165],"inference-based":[95,126,166],"method":[98],"enhance":[100],"performance.":[101],"First,a":[102],"heterogeneous":[103],"information":[104],"network":[105,142],"(HIN)":[106],"construct":[108],"by":[109],"integrating":[110],"multiple":[111],"sources.":[114],"We":[115],"employ":[116],"community":[117],"detection":[118],"HIN":[121],"preform":[123],"method,":[127],"deriving":[128],"augmented":[129,133],"links":[130],"and":[131,149],"an":[132],"HIN.":[134],"Subsequently,":[135],"apply":[137],"meta-path-based":[139],"graph":[140],"neural":[141],"obtain":[144],"high-quality":[145],"representations":[146],"drugs":[148],"effects,":[151],"enabling":[152],"DSAs.":[156],"Our":[157],"comprehensive":[158],"experiments":[159],"confirm":[160],"effectiveness":[162],"prediction.":[171]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}