{"id":"https://openalex.org/W4390992054","doi":"https://doi.org/10.1109/bibm58861.2023.10385815","title":"Disease Treatment Key Genes Identification In Heterogeneous Interaction Networks","display_name":"Disease Treatment Key Genes Identification In Heterogeneous Interaction Networks","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390992054","doi":"https://doi.org/10.1109/bibm58861.2023.10385815"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10385815","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385815","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100362634","display_name":"Wenhao Li","orcid":"https://orcid.org/0000-0003-1631-7697"},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenhao Li","raw_affiliation_strings":["Xidian University,School of Computer Science and Technology,Xi&#x2019;an,China"],"affiliations":[{"raw_affiliation_string":"Xidian University,School of Computer Science and Technology,Xi&#x2019;an,China","institution_ids":["https://openalex.org/I149594827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054607668","display_name":"Bingbo Wang","orcid":"https://orcid.org/0000-0002-1808-1852"},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingbo Wang","raw_affiliation_strings":["Xidian University,School of Computer Science and Technology,Xi&#x2019;an,China"],"affiliations":[{"raw_affiliation_string":"Xidian University,School of Computer Science and Technology,Xi&#x2019;an,China","institution_ids":["https://openalex.org/I149594827"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101352781","display_name":"Junru Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I149594827","display_name":"Xidian University","ror":"https://ror.org/05s92vm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I149594827"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junru Zheng","raw_affiliation_strings":["Xidian University,School of Computer Science and Technology,Xi&#x2019;an,China"],"affiliations":[{"raw_affiliation_string":"Xidian University,School of Computer Science and Technology,Xi&#x2019;an,China","institution_ids":["https://openalex.org/I149594827"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100362634"],"corresponding_institution_ids":["https://openalex.org/I149594827"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33836536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"3642","last_page":"3649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9488000273704529,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5918216109275818},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5820431113243103},{"id":"https://openalex.org/keywords/theophylline","display_name":"Theophylline","score":0.5576488971710205},{"id":"https://openalex.org/keywords/coding","display_name":"Coding (social sciences)","score":0.5465701222419739},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4635182321071625},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.45440763235092163},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.4543265104293823},{"id":"https://openalex.org/keywords/heterogeneous-network","display_name":"Heterogeneous network","score":0.44684356451034546},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4258320927619934},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3093045949935913},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.20071670413017273},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18836921453475952},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10015034675598145}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5918216109275818},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5820431113243103},{"id":"https://openalex.org/C2778095195","wikidata":"https://www.wikidata.org/wiki/Q407308","display_name":"Theophylline","level":2,"score":0.5576488971710205},{"id":"https://openalex.org/C179518139","wikidata":"https://www.wikidata.org/wiki/Q5140297","display_name":"Coding (social sciences)","level":2,"score":0.5465701222419739},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4635182321071625},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.45440763235092163},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.4543265104293823},{"id":"https://openalex.org/C158207573","wikidata":"https://www.wikidata.org/wiki/Q5747224","display_name":"Heterogeneous network","level":4,"score":0.44684356451034546},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4258320927619934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3093045949935913},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20071670413017273},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18836921453475952},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10015034675598145},{"id":"https://openalex.org/C108037233","wikidata":"https://www.wikidata.org/wiki/Q11375","display_name":"Wireless network","level":3,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10385815","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385815","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W2056782561","https://openalex.org/W2062533676","https://openalex.org/W2076827940","https://openalex.org/W2093598191","https://openalex.org/W2103017472","https://openalex.org/W2110553827","https://openalex.org/W2111020654","https://openalex.org/W2130687290","https://openalex.org/W2131161884","https://openalex.org/W2132022337","https://openalex.org/W2134118500","https://openalex.org/W2158293950","https://openalex.org/W2294302252","https://openalex.org/W2602233541","https://openalex.org/W2612436700","https://openalex.org/W2616561032","https://openalex.org/W2767891136","https://openalex.org/W2888838927","https://openalex.org/W2895679848","https://openalex.org/W2896002881","https://openalex.org/W2900841953","https://openalex.org/W2917858269","https://openalex.org/W2950595506","https://openalex.org/W3005336815","https://openalex.org/W3008903812","https://openalex.org/W3137864305","https://openalex.org/W3204559909","https://openalex.org/W3215223367","https://openalex.org/W4206904468","https://openalex.org/W4213104910","https://openalex.org/W4255156463","https://openalex.org/W4285132881","https://openalex.org/W4321004782","https://openalex.org/W4322832229","https://openalex.org/W6604597423"],"related_works":["https://openalex.org/W2472660848","https://openalex.org/W2091818840","https://openalex.org/W2904348443","https://openalex.org/W2982584908","https://openalex.org/W2420613639","https://openalex.org/W1977649247","https://openalex.org/W28067814","https://openalex.org/W2319698807","https://openalex.org/W2140725853","https://openalex.org/W2327088557"],"abstract_inverted_index":{"Systematically,":[0],"network":[1,7,107],"pharmacology":[2],"based":[3,105],"on":[4,106],"homogeneous":[5],"interaction":[6,63,225],"of":[8,22,43,66,112,134,192,205],"encoding":[9,67],"genes":[10,50,79],"has":[11],"effectively":[12,145],"elucidated":[13],"treatment":[14,113,164,186],"effects,":[15],"multiple":[16,189],"actions,":[17],"and":[18,31,45,51,71,80,90,119,141,148,177,197,213],"associated":[19],"side":[20,203,232],"effects":[21,223],"drugs":[23,140,244],"by":[24,208],"quantifying":[25,102],"the":[26,41,85,91,110,160,179,198,202],"proximity":[27,86],"between":[28,87],"disease":[29],"modules":[30,89,93],"drug":[32,88,127,163,222],"modules.":[33],"However,":[34],"further":[35],"exploration":[36],"is":[37],"required":[38],"to":[39,54,59,201],"understand":[40],"contributions":[42],"heterogeneous":[44,62,147,212],"multi-scale":[46,149,214],"factors,":[47],"including":[48],"non-coding":[49,69,78,117],"GO":[52,72,81,120],"Terms,":[53],"proximity.":[55],"This":[56],"study":[57],"aims":[58],"integrate":[60],"a":[61,131,169,237],"network(HIN)":[64],"consisting":[65],"genes,":[68,70,116,118],"Terms.":[73],"We":[74],"find":[75],"that":[76,154],"incorporating":[77],"Terms":[82],"significantly":[83],"enhances":[84],"diseases":[92,229,246],"they":[94],"address.":[95],"Additionally,":[96],"we":[97,144,172],"propose":[98],"an":[99],"index":[100],"for":[101,165,187,194,220,241],"crucial":[103,156],"nodes":[104],"proximity,":[108],"enabling":[109],"identification":[111],"key":[114],"coding":[115],"terms":[121],"(T<inf":[122],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[123,151,175,216],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">key</inf>)":[124],"involved":[125,183],"in":[126,158,184,224,247],"effect":[128,204],"processes.":[129],"In":[130,210],"systematic":[132],"validation":[133],"712":[135],"drug-disease":[136,248],"pairs":[137],"encompassing":[138],"471":[139],"35":[142],"diseases,":[143],"identify":[146],"T<inf":[150,174,215],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">key</inf>":[152,176,217],"factors":[153],"play":[155],"roles":[157],"elucidating":[159],"mechanisms":[161],"underlying":[162],"various":[166],"diseases.":[167],"As":[168],"case":[170],"study,":[171],"present":[173],"elucidate":[178],"pivotal":[180],"biological":[181],"pathways":[182,199],"Theophylline":[185,190,193],"Asthma,":[188],"actions":[191],"Pulmouary":[195],"Emphysema,":[196],"leading":[200],"Hypotension":[206],"induced":[207],"Theophylline.":[209],"conclusion,":[211],"are":[218],"imperative":[219],"mediating":[221],"networks,":[226],"thus":[227],"treating":[228],"or":[230],"causing":[231],"effects.":[233],"Our":[234],"research":[235],"presents":[236],"feasible":[238],"computational":[239],"tool":[240],"understanding":[242],"how":[243],"treat":[245],"relationship":[249],"analysis.":[250]},"counts_by_year":[],"updated_date":"2025-12-25T23:11:45.687758","created_date":"2025-10-10T00:00:00"}
