{"id":"https://openalex.org/W4390992006","doi":"https://doi.org/10.1109/bibm58861.2023.10385762","title":"Metapath-aggregated multilevel graph embedding for miRNA\u2012disease association prediction","display_name":"Metapath-aggregated multilevel graph embedding for miRNA\u2012disease association prediction","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390992006","doi":"https://doi.org/10.1109/bibm58861.2023.10385762"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10385762","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm58861.2023.10385762","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103873465","display_name":"Wen Cao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Cao","raw_affiliation_strings":["University of Chinese Academy of Science,College of Life Sciences,Beijing,China,100049"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chinese Academy of Science,College of Life Sciences,Beijing,China,100049","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101465750","display_name":"Chen Yang","orcid":"https://orcid.org/0000-0002-3284-8554"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Chen","raw_affiliation_strings":["Huazhong Agricultural University,College of Informatics,Wuhan,China,430070"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,College of Informatics,Wuhan,China,430070","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015411300","display_name":"Jianye Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Ye Yang","raw_affiliation_strings":["Huazhong Agricultural University,College of Informatics,Wuhan,China,430070"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,College of Informatics,Wuhan,China,430070","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102239608","display_name":"Feiyang Xue","orcid":"https://orcid.org/0000-0002-8427-1195"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei-Yang Xue","raw_affiliation_strings":["Huazhong Agricultural University,College of Informatics,Wuhan,China,430070"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,College of Informatics,Wuhan,China,430070","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100583019","display_name":"Zhan-Hui Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhan-Hui Yu","raw_affiliation_strings":["Huazhong Agricultural University,College of Informatics,Wuhan,China,430070"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,College of Informatics,Wuhan,China,430070","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113124011","display_name":"Jing Feng","orcid":null},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Feng","raw_affiliation_strings":["Huazhong Agricultural University,College of Informatics,Wuhan,China,430070"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,College of Informatics,Wuhan,China,430070","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083670525","display_name":"Zejun Wu","orcid":"https://orcid.org/0000-0001-7864-9297"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ze-Jun Wu","raw_affiliation_strings":["Huazhong Agricultural University,College of Informatics,Wuhan,China,430070"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,College of Informatics,Wuhan,China,430070","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022557533","display_name":"Jing Gong","orcid":"https://orcid.org/0000-0003-1895-2993"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Gong","raw_affiliation_strings":["Huazhong Agricultural University,College of Informatics,Wuhan,China,430070"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,College of Informatics,Wuhan,China,430070","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072833116","display_name":"Xiaohui Niu","orcid":"https://orcid.org/0000-0001-6801-2030"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Hui Niu","raw_affiliation_strings":["Huazhong Agricultural University,College of Informatics,Wuhan,China,430070"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huazhong Agricultural University,College of Informatics,Wuhan,China,430070","institution_ids":["https://openalex.org/I204823248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8185,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.86700343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"468","last_page":"473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6567763090133667},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.5298259854316711},{"id":"https://openalex.org/keywords/embedding","display_name":"Embedding","score":0.4568716585636139},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.45402413606643677},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3276703953742981},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.32079407572746277},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.054609060287475586}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6567763090133667},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.5298259854316711},{"id":"https://openalex.org/C41608201","wikidata":"https://www.wikidata.org/wiki/Q980509","display_name":"Embedding","level":2,"score":0.4568716585636139},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.45402413606643677},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3276703953742981},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.32079407572746277},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.054609060287475586},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10385762","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm58861.2023.10385762","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322186","display_name":"Natural Science Foundation of Hubei Province","ror":null},{"id":"https://openalex.org/F4320324775","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W2106029302","https://openalex.org/W2115440941","https://openalex.org/W2162674813","https://openalex.org/W2575293459","https://openalex.org/W2592189645","https://openalex.org/W2767061187","https://openalex.org/W2941271674","https://openalex.org/W3004507689","https://openalex.org/W3092487493","https://openalex.org/W3103513278","https://openalex.org/W4200542843","https://openalex.org/W4206703149","https://openalex.org/W4210548518","https://openalex.org/W4246271082","https://openalex.org/W4281553978","https://openalex.org/W4281685099","https://openalex.org/W4294376371","https://openalex.org/W4294811162","https://openalex.org/W4311823641","https://openalex.org/W4313423934","https://openalex.org/W4320857183","https://openalex.org/W4323974793","https://openalex.org/W4366464062","https://openalex.org/W4384827482","https://openalex.org/W4385072429","https://openalex.org/W6758075616"],"related_works":["https://openalex.org/W2081900870","https://openalex.org/W2345479200","https://openalex.org/W2183306018","https://openalex.org/W2352440174","https://openalex.org/W2849310602","https://openalex.org/W3006008237","https://openalex.org/W4309440960","https://openalex.org/W2419146053","https://openalex.org/W4388890789","https://openalex.org/W2932872266"],"abstract_inverted_index":{"MicroRNAs":[0],"(miRNAs)":[1],"are":[2,36],"crucial":[3],"regulators":[4],"in":[5,198,215],"various":[6],"diseases.":[7,107],"The":[8,83],"identification":[9],"of":[10,21,47,113,162,167,205],"associations":[11,59,136,192],"between":[12],"miRNAs":[13,91,105],"and":[14,24,30,45,52,64,92,106,120,164,187,211],"diseases":[15],"could":[16,193],"greatly":[17],"facilitate":[18],"the":[19,42,87,96,116,130,133,148,170,174,178,181,188,202,212],"investigation":[20],"disease":[22,80,135,217],"mechanisms":[23],"drug":[25],"development.":[26],"Limited":[27],"by":[28,124],"time":[29],"cost":[31],"efficiency,":[32],"conventional":[33],"experimental":[34,149],"techniques":[35],"inadequate":[37],"for":[38,56,78,104,169],"this":[39,68],"purpose.":[40],"With":[41,177],"extensive":[43],"advance":[44],"application":[46],"deep":[48],"learning,":[49],"developing":[50],"efficient":[51],"accurate":[53],"computational":[54],"models":[55],"predicting":[57],"miRNA\u2012disease":[58],"has":[60],"a":[61,72],"vital":[62],"role":[63],"is":[65],"feasible.":[66],"In":[67],"study,":[69,180],"we":[70,109],"proposed":[71],"meta-path-aggregated":[73],"multilevel":[74],"graph":[75,119,126,139],"embedding":[76],"model":[77,84,131,154,207],"miRNA\u2012":[79,134],"association":[81],"prediction.":[82],"first":[85],"calculated":[86],"multiple":[88],"similarities":[89],"among":[90],"diseases,":[93],"respectively.":[94],"Then,":[95],"node":[97,122],"features":[98],"were":[99],"extracted":[100],"from":[101,115],"similarity":[102],"matrices":[103],"Furthermore,":[108],"integrated":[110],"four":[111],"types":[112],"meta-paths":[114],"miRNA\u2012lncRNA\u2012disease":[117],"heterogeneous":[118],"learned":[121],"embeddings":[123],"hierarchical":[125],"attention":[127],"modules.":[128],"Finally,":[129],"predicted":[132,191],"using":[137],"two-layer":[138],"convolution":[140],"networks":[141],"(GCNs).":[142],"Compared":[143],"with":[144,159],"six":[145],"state-of-the-art":[146],"models,":[147],"results":[150],"demonstrated":[151],"that":[152],"our":[153,206],"achieved":[155],"higher":[156],"prediction":[157],"performance":[158,183],"an":[160,165],"AUC":[161],"0.9892":[163],"AUPR":[166],"0.9898":[168],"5-fold":[171],"cross-validation":[172],"on":[173],"HMDDv3.2":[175],"dataset.":[176],"case":[179],"model\u2019s":[182],"was":[184],"further":[185],"validated,":[186],"top":[189],"20":[190],"be":[194],"experimentally":[195],"confirmed.":[196],"All":[197],"all,":[199],"it":[200],"implies":[201],"predictive":[203],"power":[204],"<sup":[208],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[209],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">1</sup>":[210],"potential":[213],"value":[214],"understanding":[216],"pathology.":[218]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
