{"id":"https://openalex.org/W4390992073","doi":"https://doi.org/10.1109/bibm58861.2023.10385543","title":"The Exploration of the Mechanism of Qiwei Baizhu San in the Treatment of Type 2 Diabetes Based on Network Pharmacology Integrating Macromolecular Docking","display_name":"The Exploration of the Mechanism of Qiwei Baizhu San in the Treatment of Type 2 Diabetes Based on Network Pharmacology Integrating Macromolecular Docking","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390992073","doi":"https://doi.org/10.1109/bibm58861.2023.10385543"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10385543","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385543","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100713162","display_name":"Shi-Yao Chen","orcid":"https://orcid.org/0000-0001-6403-1349"},"institutions":[{"id":"https://openalex.org/I4210161139","display_name":"Second Affiliated Hospital of Shandong University of TCM","ror":"https://ror.org/057bhmh42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161139"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shiyao Chen","raw_affiliation_strings":["Shandong University of TCM,School of TCM,Jinan,China","School of TCM, Shandong University of TCM, Jinan, China"],"affiliations":[{"raw_affiliation_string":"Shandong University of TCM,School of TCM,Jinan,China","institution_ids":["https://openalex.org/I4210161139"]},{"raw_affiliation_string":"School of TCM, Shandong University of TCM, Jinan, China","institution_ids":["https://openalex.org/I4210161139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321581","display_name":"Shuang Zhang","orcid":"https://orcid.org/0000-0003-4556-2333"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Zhang","raw_affiliation_strings":["Shandong University of TCM,School of Foreign Language,Jinan,China","School of Foreign Language, Shandong University of TCM, Jinan, China"],"affiliations":[{"raw_affiliation_string":"Shandong University of TCM,School of Foreign Language,Jinan,China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"School of Foreign Language, Shandong University of TCM, Jinan, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043730507","display_name":"Rufan Cao","orcid":null},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rufan Cao","raw_affiliation_strings":["Shandong University of TCM,The First Clinical Medical College,Jinan,China","The First Clinical Medical College, Shandong University of TCM, Jinan, China"],"affiliations":[{"raw_affiliation_string":"Shandong University of TCM,The First Clinical Medical College,Jinan,China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"The First Clinical Medical College, Shandong University of TCM, Jinan, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390692","display_name":"Xinyu Zhang","orcid":"https://orcid.org/0000-0002-2031-9348"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Zhang","raw_affiliation_strings":["Shandong University of TCM,The First Clinical Medical College,Jinan,China","The First Clinical Medical College, Shandong University of TCM, Jinan, China"],"affiliations":[{"raw_affiliation_string":"Shandong University of TCM,The First Clinical Medical College,Jinan,China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"The First Clinical Medical College, Shandong University of TCM, Jinan, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018300251","display_name":"Liangqing Guo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210161139","display_name":"Second Affiliated Hospital of Shandong University of TCM","ror":"https://ror.org/057bhmh42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161139"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangqing Guo","raw_affiliation_strings":["University of TCM,Affiliated Hospital of Shandong,Department of Endocrine,Jinan,China","Department of Endocrine, Affiliated Hospital of Shandong, University of TCM, Jinan, China"],"affiliations":[{"raw_affiliation_string":"University of TCM,Affiliated Hospital of Shandong,Department of Endocrine,Jinan,China","institution_ids":["https://openalex.org/I4210161139"]},{"raw_affiliation_string":"Department of Endocrine, Affiliated Hospital of Shandong, University of TCM, Jinan, China","institution_ids":["https://openalex.org/I4210161139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064755062","display_name":"Xiaochun Han","orcid":null},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaochun Han","raw_affiliation_strings":["Shandong University of TCM,School of Health,Jinan,China","School of Health, Shandong University of TCM, Jinan, China"],"affiliations":[{"raw_affiliation_string":"Shandong University of TCM,School of Health,Jinan,China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"School of Health, Shandong University of TCM, Jinan, China","institution_ids":["https://openalex.org/I154099455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100713162"],"corresponding_institution_ids":["https://openalex.org/I4210161139"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28059701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":null,"first_page":"4542","last_page":"4546"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/akt1","display_name":"AKT1","score":0.6228088736534119},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.5451428890228271},{"id":"https://openalex.org/keywords/autodock","display_name":"AutoDock","score":0.5263275504112244},{"id":"https://openalex.org/keywords/systems-pharmacology","display_name":"Systems pharmacology","score":0.5141106247901917},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5031930804252625},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4980807304382324},{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.4482670724391937},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"Mechanism of action","score":0.4441995620727539},{"id":"https://openalex.org/keywords/pi3k/akt/mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.3917601704597473},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.37405645847320557},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2605481743812561},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.2544320821762085},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.21115460991859436},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.19371113181114197},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.17430195212364197}],"concepts":[{"id":"https://openalex.org/C154137905","wikidata":"https://www.wikidata.org/wiki/Q17816452","display_name":"AKT1","level":4,"score":0.6228088736534119},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5451428890228271},{"id":"https://openalex.org/C2780152424","wikidata":"https://www.wikidata.org/wiki/Q4826062","display_name":"AutoDock","level":4,"score":0.5263275504112244},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.5141106247901917},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5031930804252625},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4980807304382324},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.4482670724391937},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4441995620727539},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.3917601704597473},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37405645847320557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2605481743812561},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2544320821762085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21115460991859436},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.19371113181114197},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17430195212364197},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10385543","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385543","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337504","display_name":"Research and Development","ror":"https://ror.org/027s68j25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W2354455883","https://openalex.org/W2462339939","https://openalex.org/W2762321620","https://openalex.org/W2787573946","https://openalex.org/W2806395673","https://openalex.org/W2889925472","https://openalex.org/W2900017146","https://openalex.org/W2909517991","https://openalex.org/W2923131065","https://openalex.org/W2998186422","https://openalex.org/W3007248192","https://openalex.org/W3007742776","https://openalex.org/W3016003132","https://openalex.org/W3017507639","https://openalex.org/W3038243707","https://openalex.org/W3081655479","https://openalex.org/W3088080395","https://openalex.org/W3119671147","https://openalex.org/W3133937752","https://openalex.org/W4285744182","https://openalex.org/W4307044382","https://openalex.org/W4309905400"],"related_works":["https://openalex.org/W4306407771","https://openalex.org/W4313250964","https://openalex.org/W4200377035","https://openalex.org/W4285026760","https://openalex.org/W4309947474","https://openalex.org/W4399896179","https://openalex.org/W3093749551","https://openalex.org/W4290465784","https://openalex.org/W4386274033","https://openalex.org/W3172040299"],"abstract_inverted_index":{"Objective":[0],"To":[1],"explore":[2],"the":[3,12,44,61,67,71,79,89,101,111],"target":[4,45,90,112],"and":[5,29,43,55,92,116,124,130,143,166,192,208,210,214],"mechanism":[6],"of":[7,14,34,47,60,70,74,81,139],"Qiwei":[8,35,75,133,184],"Baizhu":[9,36,76,134,185],"San":[10,37,77,135,186],"in":[11,78,162],"treatment":[13,80],"type":[15,48,197],"2":[16,49,198],"diabetes":[17,50,199],"based":[18],"on":[19,110,120,189],"network":[20,97],"pharmacology":[21],"integrating":[22],"macromolecular":[23],"docking.":[24],"Methods":[25],"The":[26,58],"active":[27,72,141,201],"ingredient":[28],"their":[30],"corresponding":[31],"action":[32,68],"targets":[33,69,146,150,194],"were":[38,51],"obtained":[39,52],"from":[40,53],"TCMSP":[41],"database,":[42,115],"genes":[46],"Genecards":[54],"OMIM":[56],"database.":[57],"intersection":[59,145],"two":[62],"was":[63,85],"taken":[64],"to":[65,87,99,195],"obtain":[66],"ingredients":[73,142,202],"T2DM.":[82,148],"Cytoscape":[83],"3.9.1":[84],"used":[86],"analyze":[88],"PPI":[91],"draw":[93],"a":[94,137,212],"\"drug-component-common":[95],"target\"":[96],"diagram":[98],"screen":[100],"core":[102,175,181],"components;":[103],"conduct":[104,117],"Reactome,":[105],"Wiki,":[106],"KEGG":[107],"Pathways":[108],"analysis":[109,119],"using":[113],"STRING":[114],"GO":[118],"Metascape;":[121],"use":[122],"Autodock":[123],"PyMol":[125],"software":[126],"for":[127],"Macromolecular":[128,169],"docking":[129,170],"visualization.":[131],"Result":[132],"has":[136],"total":[138],"57":[140],"202":[144],"with":[147,180],"Key":[149],"mainly":[151,160],"include":[152],"AKT1,":[153,190],"TP53,":[154],"HSP90AA1,":[155],"MAPK1,":[156],"etc.,":[157],"which":[158],"are":[159],"enriched":[161],"PI3K-Akt,":[163],"MAPK,":[164],"interleukin":[165],"other":[167,193],"pathways.":[168],"results":[171],"show":[172],"that":[173],"key":[174],"components":[176],"have":[177],"good":[178],"binding":[179],"targets.":[182],"Conclusion":[183],"can":[187],"act":[188],"MAPK1":[191],"treat":[196],"through":[200],"such":[203],"as":[204],"quercetin,":[205],"kaempferol,":[206],"luteolin,":[207],"formononetin,":[209],"play":[211],"multi-target":[213],"multi-pathway":[215],"therapeutic":[216],"role.":[217]},"counts_by_year":[],"updated_date":"2025-12-25T23:11:45.687758","created_date":"2025-10-10T00:00:00"}
