{"id":"https://openalex.org/W4390992287","doi":"https://doi.org/10.1109/bibm58861.2023.10385469","title":"Interpretable Graph Convolutional Network for Alzheimer\u2019s Disease Diagnosis using Multi-Modal Imaging Genetics","display_name":"Interpretable Graph Convolutional Network for Alzheimer\u2019s Disease Diagnosis using Multi-Modal Imaging Genetics","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390992287","doi":"https://doi.org/10.1109/bibm58861.2023.10385469"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10385469","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm58861.2023.10385469","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000655873","display_name":"Houliang Zhou","orcid":"https://orcid.org/0000-0002-5793-3042"},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Houliang Zhou","raw_affiliation_strings":["Lehigh University,Computer Science and Engineering,PA,USA","Computer Science and Engineering, Lehigh University, PA, USA"],"affiliations":[{"raw_affiliation_string":"Lehigh University,Computer Science and Engineering,PA,USA","institution_ids":["https://openalex.org/I186143895"]},{"raw_affiliation_string":"Computer Science and Engineering, Lehigh University, PA, USA","institution_ids":["https://openalex.org/I186143895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100433744","display_name":"Yu Zhang","orcid":"https://orcid.org/0000-0003-4087-6544"},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["Lehigh University,Bioengineering, and Electrical and Computer Engineering,PA,USA","Bioengineering, and Electrical and Computer Engineering, Lehigh University, PA, USA"],"affiliations":[{"raw_affiliation_string":"Lehigh University,Bioengineering, and Electrical and Computer Engineering,PA,USA","institution_ids":["https://openalex.org/I186143895"]},{"raw_affiliation_string":"Bioengineering, and Electrical and Computer Engineering, Lehigh University, PA, USA","institution_ids":["https://openalex.org/I186143895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071709543","display_name":"Lifang He","orcid":"https://orcid.org/0000-0001-7810-9071"},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lifang He","raw_affiliation_strings":["Lehigh University,Computer Science and Engineering,PA,USA","Computer Science and Engineering, Lehigh University, PA, USA"],"affiliations":[{"raw_affiliation_string":"Lehigh University,Computer Science and Engineering,PA,USA","institution_ids":["https://openalex.org/I186143895"]},{"raw_affiliation_string":"Computer Science and Engineering, Lehigh University, PA, USA","institution_ids":["https://openalex.org/I186143895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333320","display_name":"Li Shen","orcid":"https://orcid.org/0000-0002-5443-0503"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Shen","raw_affiliation_strings":["University of Pennsylvania,Biostatistics, Epidemiology and Informatics,PA,USA","Biostatistics, Epidemiology and Informatics, University of Pennsylvania, PA, USA"],"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Biostatistics, Epidemiology and Informatics,PA,USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Biostatistics, Epidemiology and Informatics, University of Pennsylvania, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062182398","display_name":"Brian Y. Chen","orcid":"https://orcid.org/0000-0001-9025-0107"},"institutions":[{"id":"https://openalex.org/I186143895","display_name":"Lehigh University","ror":"https://ror.org/012afjb06","country_code":"US","type":"education","lineage":["https://openalex.org/I186143895"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Y. Chen","raw_affiliation_strings":["Lehigh University,Computer Science and Engineering,PA,USA","Computer Science and Engineering, Lehigh University, PA, USA"],"affiliations":[{"raw_affiliation_string":"Lehigh University,Computer Science and Engineering,PA,USA","institution_ids":["https://openalex.org/I186143895"]},{"raw_affiliation_string":"Computer Science and Engineering, Lehigh University, PA, USA","institution_ids":["https://openalex.org/I186143895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000655873"],"corresponding_institution_ids":["https://openalex.org/I186143895"],"apc_list":null,"apc_paid":null,"fwci":0.6362,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.71817242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1004","last_page":"1007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11273","display_name":"Advanced Graph Neural Networks","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9815999865531921,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5893014073371887},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5162441730499268},{"id":"https://openalex.org/keywords/modal","display_name":"Modal","score":0.46731919050216675},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.45083087682724},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3859393298625946},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18646371364593506},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.17092642188072205}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5893014073371887},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5162441730499268},{"id":"https://openalex.org/C71139939","wikidata":"https://www.wikidata.org/wiki/Q910194","display_name":"Modal","level":2,"score":0.46731919050216675},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.45083087682724},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3859393298625946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18646371364593506},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.17092642188072205},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10385469","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm58861.2023.10385469","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4399999976158142,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320338440","display_name":"HORIZON EUROPE Health","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1448960299","https://openalex.org/W1534628288","https://openalex.org/W1965917470","https://openalex.org/W2005821483","https://openalex.org/W2103017472","https://openalex.org/W2155513557","https://openalex.org/W2914372520","https://openalex.org/W2921571031","https://openalex.org/W3002127012","https://openalex.org/W4295917610","https://openalex.org/W4296121294","https://openalex.org/W4387225880","https://openalex.org/W6726873649"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W4402327032","https://openalex.org/W2382290278"],"abstract_inverted_index":{"Integrating":[0],"brain":[1,23,91],"images":[2],"and":[3,22,39,64,84,151,165],"genetic":[4,20,40,50],"data":[5],"provides":[6],"a":[7,27,57,78,104],"great":[8],"opportunity":[9],"to":[10,55,88,110,140],"discover":[11],"potential":[12],"biomarkers":[13],"for":[14,45,168],"neurological":[15],"disorder":[16],"diagnosis.":[17,48],"However,":[18],"learning":[19],"information":[21,67],"network":[24,43,51,76,92],"dysfunction":[25],"remains":[26],"challenging":[28],"task.":[29],"In":[30,72],"this":[31,70],"paper,":[32],"we":[33],"propose":[34],"an":[35],"interpretable":[36,80],"multi-modal":[37,94,97],"imaging":[38,75],"graph":[41,60],"convolution":[42],"(GCN)":[44],"Alzheimer\u2019s":[46,122],"disease":[47],"Our":[49,128],"uses":[52,77],"hierarchical":[53],"GCN":[54,81],"mimic":[56],"gene":[58],"ontology-based":[59],"of":[61],"biological":[62],"processes":[63],"learn":[65,89],"the":[66,90,99,112,121,148],"flow":[68],"in":[69],"graph.":[71],"parallel,":[73],"our":[74,118,132],"sparse":[79],"with":[82,161],"node":[83],"edge":[85],"importance":[86],"probabilities":[87,157],"from":[93],"images.":[95],"After":[96],"fusion,":[98],"final":[100],"representation":[101],"guided":[102],"by":[103,155],"cluster-based":[105],"consistency":[106],"constraint":[107],"is":[108,174],"used":[109],"predict":[111],"disease-related":[113],"clinical":[114,163],"measures.":[115],"We":[116],"evaluate":[117],"method":[119],"on":[120],"Disease":[123],"Neuroimaging":[124],"Initiative":[125],"(ADNI)":[126],"database.":[127],"result":[129],"shows":[130],"that":[131,147],"imaging-genetics":[133],"framework":[134],"achieves":[135],"superior":[136],"prediction":[137],"performance":[138],"compared":[139],"all":[141],"state-of-the-art":[142],"methods.":[143],"The":[144,172],"interpretation":[145],"demonstrated":[146],"salient":[149,152],"SNPs,":[150],"regions":[153],"interpreted":[154],"important":[156,167],"were":[158],"significantly":[159],"correlated":[160],"AD-related":[162],"symptoms,":[164],"considerably":[166],"developing":[169],"novel":[170],"biomarkers.":[171],"code":[173],"available":[175],"at":[176],"https://github.com/Houliang-Zhou/IG-GCN.":[177]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}