{"id":"https://openalex.org/W4390992257","doi":"https://doi.org/10.1109/bibm58861.2023.10385397","title":"Explore the treatment of depression with Radix Bupleuri from the liver and spleen based on the theory of brain-gut axis","display_name":"Explore the treatment of depression with Radix Bupleuri from the liver and spleen based on the theory of brain-gut axis","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390992257","doi":"https://doi.org/10.1109/bibm58861.2023.10385397"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10385397","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385397","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101293697","display_name":"Xue-Hong Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue-Hong Zheng","raw_affiliation_strings":["Shandong University of Traditional Chinese Medicine,College of Pharmacy,Jinan,China","College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University of Traditional Chinese Medicine,College of Pharmacy,Jinan,China","institution_ids":["https://openalex.org/I134738993"]},{"raw_affiliation_string":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100762514","display_name":"Zhiyuan Yu","orcid":"https://orcid.org/0000-0002-2178-6423"},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Yuan Yu","raw_affiliation_strings":["Shandong University of Traditional Chinese Medicine,College of Traditional Chinese Medicine,Jinan,China","College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University of Traditional Chinese Medicine,College of Traditional Chinese Medicine,Jinan,China","institution_ids":["https://openalex.org/I134738993"]},{"raw_affiliation_string":"College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101621517","display_name":"Yanxin Zhang","orcid":"https://orcid.org/0000-0002-7334-9161"},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Xin Zhang","raw_affiliation_strings":["Shandong University of Traditional Chinese Medicine,Institute for Literature and Culture of Chinese Medicine,Jinan,China","Institute for Literature and Culture of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University of Traditional Chinese Medicine,Institute for Literature and Culture of Chinese Medicine,Jinan,China","institution_ids":["https://openalex.org/I134738993"]},{"raw_affiliation_string":"Institute for Literature and Culture of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xin-Xin Shao","orcid":null},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin-Xin Shao","raw_affiliation_strings":["Shandong University of Traditional Chinese Medicine,First School of Clinical Medicine,Jinan,China","First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University of Traditional Chinese Medicine,First School of Clinical Medicine,Jinan,China","institution_ids":["https://openalex.org/I134738993"]},{"raw_affiliation_string":"First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100427094","display_name":"Cong Chen","orcid":"https://orcid.org/0000-0001-5035-1026"},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cong Chen","raw_affiliation_strings":["Shandong University of Traditional Chinese Medicine,Institute for Literature and Culture of Chinese Medicine,Jinan,China","Institute for Literature and Culture of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University of Traditional Chinese Medicine,Institute for Literature and Culture of Chinese Medicine,Jinan,China","institution_ids":["https://openalex.org/I134738993"]},{"raw_affiliation_string":"Institute for Literature and Culture of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100438174","display_name":"Jia Li","orcid":"https://orcid.org/0000-0002-6691-3270"},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Li","raw_affiliation_strings":["Shandong University of Traditional Chinese Medicine,College of Pharmacy,Jinan,China","College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University of Traditional Chinese Medicine,College of Pharmacy,Jinan,China","institution_ids":["https://openalex.org/I134738993"]},{"raw_affiliation_string":"College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China","institution_ids":["https://openalex.org/I134738993"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I134738993"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":null,"first_page":"4733","last_page":"4740"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.982699990272522,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.982699990272522,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9674999713897705,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavones","display_name":"Flavones","score":0.6568300127983093},{"id":"https://openalex.org/keywords/radix","display_name":"Radix (gastropod)","score":0.5511811971664429},{"id":"https://openalex.org/keywords/antidepressant","display_name":"Antidepressant","score":0.5240626335144043},{"id":"https://openalex.org/keywords/serotonergic","display_name":"Serotonergic","score":0.48344478011131287},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.45539987087249756},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.44062909483909607},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"Traditional Chinese medicine","score":0.4323304295539856},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4210602939128876},{"id":"https://openalex.org/keywords/spleen","display_name":"Spleen","score":0.4161287248134613},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"Traditional medicine","score":0.3912285268306732},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.33210456371307373},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31734877824783325},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2320738136768341},{"id":"https://openalex.org/keywords/serotonin","display_name":"Serotonin","score":0.17367777228355408},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1515512764453888},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.12563353776931763},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.08432784676551819}],"concepts":[{"id":"https://openalex.org/C2776292868","wikidata":"https://www.wikidata.org/wiki/Q424525","display_name":"Flavones","level":2,"score":0.6568300127983093},{"id":"https://openalex.org/C2779091547","wikidata":"https://www.wikidata.org/wiki/Q287565","display_name":"Radix (gastropod)","level":2,"score":0.5511811971664429},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.5240626335144043},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.48344478011131287},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.45539987087249756},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44062909483909607},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.4323304295539856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4210602939128876},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.4161287248134613},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3912285268306732},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33210456371307373},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31734877824783325},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2320738136768341},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.17367777228355408},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1515512764453888},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12563353776931763},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.08432784676551819},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10385397","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385397","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.800000011920929,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W347526702","https://openalex.org/W1015713818","https://openalex.org/W1954242598","https://openalex.org/W1969140399","https://openalex.org/W2016810230","https://openalex.org/W2035021435","https://openalex.org/W2038754710","https://openalex.org/W2069791716","https://openalex.org/W2072921205","https://openalex.org/W2150220236","https://openalex.org/W2159040093","https://openalex.org/W2164342861","https://openalex.org/W2324730741","https://openalex.org/W2339700702","https://openalex.org/W2484327514","https://openalex.org/W2562159750","https://openalex.org/W2602895543","https://openalex.org/W2617315078","https://openalex.org/W2733140764","https://openalex.org/W2762626802","https://openalex.org/W2883871681","https://openalex.org/W2933773264","https://openalex.org/W2997744578","https://openalex.org/W3006836785","https://openalex.org/W3021086331","https://openalex.org/W4254023768"],"related_works":["https://openalex.org/W1533935771","https://openalex.org/W167444214","https://openalex.org/W2369448566","https://openalex.org/W4301240684","https://openalex.org/W2382832752","https://openalex.org/W2392204654","https://openalex.org/W2350706715","https://openalex.org/W2355119599","https://openalex.org/W2418446309","https://openalex.org/W2025449574"],"abstract_inverted_index":{"Objective":[0],"Taking":[1],"the":[2,7,12,24,29,39,47,62,69,77,113,119,129,137,143,183,191,197,201,213,221,229,249],"brain-gut":[3,44,192,226],"axis":[4,45,193,227],"theory":[5],"as":[6,74,76,155,166,175],"strating":[8],"point,":[9],"it":[10],"explains":[11],"modern":[13,56],"scientific":[14,237],"connotation":[15],"of":[16,31,38,49,65,83,132,185,190,200,208,215,220,231,242,251],"traditional":[17],"Chinese":[18],"medicine":[19],"(TCM)":[20],"treating":[21],"depression":[22],"from":[23],"Gan":[25,202],"and":[26,41,55,71,80,97,100,134,158,178,203,223,236,244],"Pi,":[27],"explore":[28],"mechanism":[30,214],"Radix":[32,84,140,216],"Bupleuri<sup":[33],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[34],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">1</sup>":[35],"realizing":[36,218],"co-regulation":[37,219],"liver":[40,114,133,222],"intestines":[42,224],"through":[43,161,225],"in":[46,68,95,106,205,228],"treatment":[48,184,230,241],"depression.":[50,186,232],"Methods":[51],"By":[52],"association":[53],"rules":[54],"biological":[57],"information":[58],"mining":[59],"methods,":[60],"analysis":[61],"protein":[63,92],"expression":[64,93],"depression-related":[66],"targets":[67,79,89,164],"brain":[70,96],"intestine":[72],"tissues,":[73,99],"well":[75],"core":[78,163],"main":[81],"mechanisms":[82],"Bupleuri":[85,141,217],"antidepressant.":[86],"Results":[87],"Depression-related":[88],"had":[90],"similar":[91,195],"levels":[94],"intestinal":[98],"there":[101,123],"is":[102,124,142,194],"a":[103,125],"strong":[104],"relationship":[105,127],"between.":[107],"The":[108,188],"antidepressant":[109,253],"TCM":[110],"belongs":[111],"to":[112,181,196],"meridian":[115],"most,":[116],"followed":[117],"by":[118],"spleen":[120],"meridian.":[121],"And":[122],"close":[126],"between":[128],"two":[130],"meridians":[131],"spleen.":[135],"Among":[136],"antidepression":[138],"TCM,":[139],"most":[144],"commonly":[145],"used":[146],"one":[147],"except":[148],"licorice.":[149],"It":[150],"contains":[151],"active":[152],"constituents":[153],"such":[154,165,174],"flavones,":[156],"steroids,":[157],"terpenes.":[159],"Mainly":[160],"7":[162],"MAOA,":[167],"GSK3B,":[168],"SLC6A4,":[169],"etc.,":[170],"regulating":[171],"10":[172],"pathways":[173],"Serotonergic":[176],"synapse":[177,180],"Dopaminergic":[179],"realize":[182],"Conclusion":[187],"role":[189],"physiological":[198],"function":[199],"Pi":[204],"theoretical":[206],"system":[207],"TCM.":[209],"This":[210],"study":[211],"reveals":[212],"Provide":[233],"new":[234,252],"ideas":[235],"explanations":[238],"for":[239,248],"clinical":[240],"depression,":[243],"provide":[245],"data":[246],"support":[247],"development":[250],"drugs.":[254]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}