{"id":"https://openalex.org/W4390971326","doi":"https://doi.org/10.1109/bibm58861.2023.10385376","title":"High-Activity Enhancer Generation based on Feedback GAN with Domain Constraint and Curriculum Learning","display_name":"High-Activity Enhancer Generation based on Feedback GAN with Domain Constraint and Curriculum Learning","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390971326","doi":"https://doi.org/10.1109/bibm58861.2023.10385376"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10385376","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385376","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100328383","display_name":"Jia-Hao Li","orcid":"https://orcid.org/0009-0003-2889-0965"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahao Li","raw_affiliation_strings":["Harbin Institute of Technology,School of Compter Science and Technology,Shenzhen,China","School of Compter Science and Technology, Harbin Institute of Technology, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology,School of Compter Science and Technology,Shenzhen,China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Compter Science and Technology, Harbin Institute of Technology, Shenzhen, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061842825","display_name":"Liwei Xiao","orcid":"https://orcid.org/0000-0001-6971-9222"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liwei Xiao","raw_affiliation_strings":["Harbin Institute of Technology,School of Compter Science and Technology,Shenzhen,China","School of Compter Science and Technology, Harbin Institute of Technology, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology,School of Compter Science and Technology,Shenzhen,China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Compter Science and Technology, Harbin Institute of Technology, Shenzhen, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026469278","display_name":"Jiawei Luo","orcid":"https://orcid.org/0000-0003-2385-8272"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Luo","raw_affiliation_strings":["Harbin Institute of Technology,School of Compter Science and Technology,Shenzhen,China","School of Compter Science and Technology, Harbin Institute of Technology, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology,School of Compter Science and Technology,Shenzhen,China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Compter Science and Technology, Harbin Institute of Technology, Shenzhen, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104215392","display_name":"Xianliang Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianliang Liu","raw_affiliation_strings":["Harbin Institute of Technology,School of Compter Science and Technology,Shenzhen,China","School of Compter Science and Technology, Harbin Institute of Technology, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology,School of Compter Science and Technology,Shenzhen,China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Compter Science and Technology, Harbin Institute of Technology, Shenzhen, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100365536","display_name":"Junjie Chen","orcid":"https://orcid.org/0000-0002-0483-303X"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junjie Chen","raw_affiliation_strings":["Harbin Institute of Technology,School of Compter Science and Technology,Shenzhen,China","School of Compter Science and Technology, Harbin Institute of Technology, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology,School of Compter Science and Technology,Shenzhen,China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Compter Science and Technology, Harbin Institute of Technology, Shenzhen, China","institution_ids":["https://openalex.org/I204983213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204983213"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":null,"first_page":"2065","last_page":"2070"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enhancer","display_name":"Enhancer","score":0.9575613141059875},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5638031959533691},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.507616400718689},{"id":"https://openalex.org/keywords/constraint","display_name":"Constraint (computer-aided design)","score":0.43962448835372925},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.4183007478713989},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4078252613544464},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38350149989128113},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19574642181396484},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.16025012731552124}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.9575613141059875},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5638031959533691},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.507616400718689},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.43962448835372925},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4183007478713989},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4078252613544464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38350149989128113},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19574642181396484},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.16025012731552124},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10385376","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm58861.2023.10385376","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1965425724","https://openalex.org/W2020816856","https://openalex.org/W2170747616","https://openalex.org/W2183523328","https://openalex.org/W2296073425","https://openalex.org/W2784920021","https://openalex.org/W2913423296","https://openalex.org/W3006431270","https://openalex.org/W3027404681","https://openalex.org/W3034103023","https://openalex.org/W3096418018","https://openalex.org/W3127238141","https://openalex.org/W3135130381","https://openalex.org/W3139265997","https://openalex.org/W3164328317","https://openalex.org/W3173029858","https://openalex.org/W4280563114","https://openalex.org/W4281898027","https://openalex.org/W4295521014","https://openalex.org/W4360938365","https://openalex.org/W4362589790","https://openalex.org/W4380870878","https://openalex.org/W6731175945","https://openalex.org/W6735913928"],"related_works":["https://openalex.org/W2113330652","https://openalex.org/W2061914098","https://openalex.org/W4393004084","https://openalex.org/W4309683845","https://openalex.org/W2118646732","https://openalex.org/W4303699336","https://openalex.org/W2152841149","https://openalex.org/W2586783543","https://openalex.org/W4387598842","https://openalex.org/W2973036402"],"abstract_inverted_index":{"Enhancers":[0],"are":[1],"important":[2],"cis-regulatory":[3],"elements,":[4],"enhancing":[5],"the":[6,47,57,117,124,134],"transcription":[7],"of":[8,14,19,33,39,60,136],"target":[9],"genes.":[10],"De":[11],"novo":[12],"design":[13,70],"high-activity":[15,76,93,101,155],"enhancers":[16,48,102,138],"is":[17,80,97,139,161],"one":[18],"long-standing":[20],"goals":[21],"in":[22,144],"generated":[23,137,154],"biology":[24],"for":[25],"both":[26,90],"clinical":[27],"purpose":[28],"and":[29,43,92,95,108,122,165],"artificial":[30],"life,":[31],"because":[32],"their":[34],"vital":[35],"roles":[36],"on":[37,83,129],"regulation":[38],"cell":[40],"development,":[41],"differentiation,":[42],"apoptosis.":[44],"But":[45],"designing":[46],"with":[49,103,168],"specific":[50],"properties":[51],"remains":[52],"challenging,":[53],"primarily":[54],"due":[55],"to":[56,74,99,115,163],"unclear":[58],"understanding":[59],"enhancer":[61,69,77,86],"regulatory":[62],"codes.":[63],"Here,":[64],"we":[65,148],"propose":[66],"an":[67],"AI-driven":[68],"method,":[71],"named":[72],"Enhancer-GAN,":[73],"generate":[75,100,164],"sequences.":[78],"Enhancer-GAN":[79,114,160],"firstly":[81],"pre-trained":[82],"a":[84],"large":[85],"dataset":[87],"that":[88,133],"contains":[89],"low-activity":[91],"enhancers,":[94],"then":[96],"optimized":[98],"feedback-loop":[104],"mechanism.":[105],"Domain":[106],"constraint":[107],"curriculum":[109],"learning":[110],"were":[111],"introduced":[112],"into":[113],"alleviate":[116],"noise":[118],"from":[119,153],"feedback":[120],"loop":[121],"accelerate":[123],"training":[125],"convergence.":[126],"Experimental":[127],"results":[128,158],"benchmark":[130,145],"datasets":[131],"demonstrate":[132,159],"activity":[135],"significantly":[140],"higher":[141],"than":[142],"ones":[143],"dataset.":[146],"Besides,":[147],"find":[149],"10":[150],"new":[151],"motifs":[152],"enhancers.":[156],"These":[157],"promising":[162],"optimize":[166],"bio-sequences":[167],"desired":[169],"properties.":[170]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
