{"id":"https://openalex.org/W4390971248","doi":"https://doi.org/10.1109/bibm58861.2023.10385302","title":"Human-Spa: An Online Platform Based on Spatial Transcriptome Data for Diseases of Human Systems","display_name":"Human-Spa: An Online Platform Based on Spatial Transcriptome Data for Diseases of Human Systems","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390971248","doi":"https://doi.org/10.1109/bibm58861.2023.10385302"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10385302","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm58861.2023.10385302","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102608590","display_name":"Yunyun Su","orcid":null},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunyun Su","raw_affiliation_strings":["Hainan University,School of Computer Science and Technology,Haikou,China","School of Computer Science and Technology, Hainan University, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan University,School of Computer Science and Technology,Haikou,China","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"School of Computer Science and Technology, Hainan University, Haikou, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101125041","display_name":"Shiyu Yan","orcid":null},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyu Yan","raw_affiliation_strings":["Hainan University,School of Life Sciences,Haikou,China","School of Life Sciences, Hainan University, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan University,School of Life Sciences,Haikou,China","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"School of Life Sciences, Hainan University, Haikou, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100611825","display_name":"Chen Cao","orcid":"https://orcid.org/0000-0001-5343-808X"},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Cao","raw_affiliation_strings":["Nanjing Medical University,School of Biomedical Engineering and Informatics,Nanjing,China","School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanjing Medical University,School of Biomedical Engineering and Informatics,Nanjing,China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061028143","display_name":"Feifei Cui","orcid":"https://orcid.org/0000-0001-7055-3813"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feifei Cui","raw_affiliation_strings":["Hainan University,School of Computer Science and Technology,Haikou,China","School of Computer Science and Technology, Hainan University, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan University,School of Computer Science and Technology,Haikou,China","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"School of Computer Science and Technology, Hainan University, Haikou, China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017426085","display_name":"Quan Zou","orcid":"https://orcid.org/0000-0001-6406-1142"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Zou","raw_affiliation_strings":["University of Electronic Science and Technology of China,Institute of Fundamental and Frontier Sciences,Chengdu,China","Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China,Institute of Fundamental and Frontier Sciences,Chengdu,China","institution_ids":["https://openalex.org/I150229711"]},{"raw_affiliation_string":"Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100353028","display_name":"Zilong Zhang","orcid":"https://orcid.org/0000-0002-4934-1258"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zilong Zhang","raw_affiliation_strings":["Hainan University,School of Computer Science and Technology,Haikou,China","School of Computer Science and Technology, Hainan University, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hainan University,School of Computer Science and Technology,Haikou,China","institution_ids":["https://openalex.org/I20942203"]},{"raw_affiliation_string":"School of Computer Science and Technology, Hainan University, Haikou, China","institution_ids":["https://openalex.org/I20942203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8559,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.75365958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"293","last_page":"298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9801999926567078,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9718000292778015,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6803404092788696},{"id":"https://openalex.org/keywords/human-disease","display_name":"Human disease","score":0.6109919548034668},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.561744749546051},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4729998707771301},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.47263047099113464},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1754988431930542},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14566779136657715},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.09835335612297058},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08657670021057129}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6803404092788696},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.6109919548034668},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.561744749546051},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4729998707771301},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47263047099113464},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1754988431930542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14566779136657715},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09835335612297058},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08657670021057129},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10385302","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm58861.2023.10385302","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","score":0.6100000143051147,"id":"https://metadata.un.org/sdg/9"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1822781126","https://openalex.org/W1988484049","https://openalex.org/W2116163278","https://openalex.org/W2118258530","https://openalex.org/W2255388164","https://openalex.org/W2485836676","https://openalex.org/W2586738019","https://openalex.org/W2613084028","https://openalex.org/W2766417776","https://openalex.org/W2894687190","https://openalex.org/W2912683648","https://openalex.org/W2915848182","https://openalex.org/W2923300855","https://openalex.org/W2926010705","https://openalex.org/W2948019310","https://openalex.org/W2972983657","https://openalex.org/W2988665559","https://openalex.org/W3003526695","https://openalex.org/W3022968840","https://openalex.org/W3092803354","https://openalex.org/W3110693579","https://openalex.org/W3135013162","https://openalex.org/W3136101359","https://openalex.org/W3147234347","https://openalex.org/W3151709979","https://openalex.org/W3172602094","https://openalex.org/W3172730298","https://openalex.org/W3217789277","https://openalex.org/W4281294892","https://openalex.org/W4306353205","https://openalex.org/W4306730653","https://openalex.org/W4307952312","https://openalex.org/W4316673487","https://openalex.org/W6718250940"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2399513595","https://openalex.org/W4388386498","https://openalex.org/W2390279801","https://openalex.org/W4327953582","https://openalex.org/W4296277698","https://openalex.org/W2044340941","https://openalex.org/W2322763599","https://openalex.org/W2014372623"],"abstract_inverted_index":{"Spatial":[0],"transcriptomics":[1],"has":[2],"become":[3],"a":[4,100,187,205],"major":[5,57],"method":[6],"for":[7,48,192,211,218],"high-throughput":[8],"analysis":[9,61,125],"of":[10,17,35,64,87,131,143,160,169,201],"gene":[11,23],"expression":[12,24],"at":[13,220],"the":[14,30,60,85,129,140,144,158,167,199],"current":[15],"level":[16],"cells,":[18,28],"which":[19],"can":[20],"directly":[21],"study":[22,86],"changes":[25],"in":[26,59,72,84,147,154,166],"disease":[27,49,155,180,213],"reveal":[29],"occurrence":[31],"and":[32,44,51,62,78,119,124,149,164,184,194,208],"development":[33,163],"mechanism":[34],"diseases,":[36,43,109,118],"identify":[37],"potential":[38],"therapeutic":[39],"targets":[40],"related":[41,105,115],"to":[42,74,98,106,111,116,127],"provide":[45,112,120,204],"new":[46],"clues":[47],"diagnosis":[50],"treatment.":[52],"Although":[53],"there":[54,67],"have":[55],"been":[56],"breakthroughs":[58],"acquisition":[63],"transcriptome":[65,102],"data,":[66],"are":[68,96],"still":[69],"many":[70],"challenges":[71],"how":[73],"effectively":[75],"manage,":[76],"share":[77],"utilize":[79],"these":[80],"valuable":[81],"data":[82,122],"resources":[83],"human":[88,107,132,170],"systemic":[89,108,133],"diseases.":[90],"To":[91],"solve":[92],"this":[93],"problem,":[94],"we":[95],"committed":[97],"building":[99],"spatial":[101],"database":[103,145],"website":[104,146],"aiming":[110],"reliable":[113],"datasets":[114],"multiple":[117],"certain":[121],"information":[123],"results":[126],"accelerate":[128],"progress":[130],"diseases":[134],"research.":[135,214],"This":[136],"paper":[137],"will":[138,203],"introduce":[139],"construction":[141,200],"process":[142],"detail,":[148],"discuss":[150],"its":[151],"application":[152],"prospects":[153],"research,":[156],"with":[157],"aim":[159],"promoting":[161],"further":[162],"innovation":[165],"field":[168],"health.":[171],"Here,":[172],"Human-spa":[173],"mainly":[174],"includes":[175],"12":[176],"Human":[177,212],"systems,":[178],"38":[179],"types,":[181],"55":[182],"datasets,":[183],"Human-Spa":[185,202,215],"provides":[186],"very":[188],"friendly":[189],"web":[190],"interface":[191],"visualization":[193],"dataset":[195],"parsing.":[196],"In":[197],"conclusion,":[198],"powerful":[206],"tool":[207],"resource":[209],"platform":[210],"is":[216],"available":[217],"free":[219],"http://www.human-spa.cn/":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
