{"id":"https://openalex.org/W4390971358","doi":"https://doi.org/10.1109/bibm58861.2023.10385283","title":"Pan-cancer analysis of HAVCR2 based on machine learning: A potential target of survival and immunotherapy","display_name":"Pan-cancer analysis of HAVCR2 based on machine learning: A potential target of survival and immunotherapy","publication_year":2023,"publication_date":"2023-12-05","ids":{"openalex":"https://openalex.org/W4390971358","doi":"https://doi.org/10.1109/bibm58861.2023.10385283"},"language":"en","primary_location":{"id":"doi:10.1109/bibm58861.2023.10385283","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm58861.2023.10385283","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019674746","display_name":"Yu Guo","orcid":"https://orcid.org/0000-0003-3541-8282"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Guo","raw_affiliation_strings":["Harbin Institute of Technology,School of Computer Science and Technology,Harbin,China","School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology,School of Computer Science and Technology,Harbin,China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100773304","display_name":"Yukai Wang","orcid":"https://orcid.org/0000-0003-3842-7942"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yukai Wang","raw_affiliation_strings":["Harbin Institute of Technology,School of Computer Science and Technology,Harbin,China","School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology,School of Computer Science and Technology,Harbin,China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037178137","display_name":"Yang Hu","orcid":"https://orcid.org/0000-0002-4508-5365"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Hu","raw_affiliation_strings":["Harbin Institute of Technology,School of Computer Science and Technology,Harbin,China","School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology,School of Computer Science and Technology,Harbin,China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100392450","display_name":"Yadong Wang","orcid":"https://orcid.org/0000-0002-0028-0263"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yadong Wang","raw_affiliation_strings":["Harbin Institute of Technology,School of Computer Science and Technology,Harbin,China","School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology,School of Computer Science and Technology,Harbin,China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204983213"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2919","last_page":"2925"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6951349973678589},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6418505907058716},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.6231762170791626},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5206674337387085},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.48787951469421387},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.4816628694534302},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.4187786281108856},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"Cancer immunotherapy","score":0.41660866141319275},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.39876148104667664},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.29252660274505615},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.225460946559906},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14965605735778809}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6951349973678589},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6418505907058716},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6231762170791626},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5206674337387085},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.48787951469421387},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4816628694534302},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4187786281108856},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.41660866141319275},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39876148104667664},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29252660274505615},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.225460946559906},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14965605735778809}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm58861.2023.10385283","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm58861.2023.10385283","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1922412259","https://openalex.org/W1982505108","https://openalex.org/W1994257755","https://openalex.org/W2031627869","https://openalex.org/W2104966044","https://openalex.org/W2107598346","https://openalex.org/W2108026478","https://openalex.org/W2149121521","https://openalex.org/W2151293773","https://openalex.org/W2568773821","https://openalex.org/W2593059553","https://openalex.org/W2611395158","https://openalex.org/W2761081415","https://openalex.org/W2970055262","https://openalex.org/W2995684511","https://openalex.org/W3006500278","https://openalex.org/W3037333252","https://openalex.org/W3039484069","https://openalex.org/W3128646645","https://openalex.org/W3128803455","https://openalex.org/W3156148127","https://openalex.org/W3203114048","https://openalex.org/W4205177974","https://openalex.org/W4221134810"],"related_works":["https://openalex.org/W4200022043","https://openalex.org/W2112727616","https://openalex.org/W2884525857","https://openalex.org/W4322720888","https://openalex.org/W4296613612","https://openalex.org/W3193904228","https://openalex.org/W3111580887","https://openalex.org/W3185708072","https://openalex.org/W2902626376","https://openalex.org/W3049036915"],"abstract_inverted_index":{"Hepatitis":[0],"A":[1],"virus":[2],"cellular":[3],"receptor":[4],"2":[5],"(HAVCR2)":[6],"is":[7,14,22],"an":[8],"immune":[9,43,162,175],"checkpoint":[10],"inhibitor,":[11],"whose":[12],"expression":[13,107,138],"closely":[15],"associated":[16,68,113,132],"with":[17,49,69,114,133,144,160,185],"tumor":[18],"exhaustion.":[19],"However,":[20],"there":[21],"no":[23,158],"systemic":[24],"pan-cancer":[25,99],"analysis":[26,77],"of":[27,65,78,93,177],"HAVCR2.":[28],"Our":[29],"study":[30],"aims":[31],"to":[32],"understand":[33],"its":[34],"multi-omics":[35,53],"profiles,":[36],"genetic":[37],"alterations,":[38],"prognostic":[39],"significance,":[40],"biological":[41],"functions,":[42],"infiltration":[44],"patterns,":[45],"and":[46,67,83,90,102,122,141,150,194,202],"the":[47,174],"relationship":[48],"drug":[50,209],"sensitivity":[51],"using":[52],"bioinformatics":[54],"from":[55],"public":[56],"databases.":[57],"HAVCR2":[58,94,106,129,137,171,181,206],"was":[59,112,182],"significantly":[60,140],"upregulated":[61],"in":[62,98,109,128,152,164],"24":[63],"types":[64],"cancers":[66,111],"prognosis,":[70],"as":[71,207],"indicated":[72],"by":[73,100],"a":[74,208],"comprehensively":[75],"integrated":[76],"The":[79,87],"Cancer":[80],"Genome":[81],"Atlas":[82],"Genotype-Tissue":[84],"Expression":[85],"portals.":[86],"DNA":[88],"methylation":[89],"protein":[91],"levels":[92],"were":[95,130],"also":[96],"assessed":[97],"UALCAN":[101],"CPTAC.":[103],"Besides,":[104,180],"high":[105],"group":[108],"different":[110],"worse":[115],"or":[116],"better":[117],"prognosis":[118],"for":[119,205],"overall":[120],"survival":[121],"disease-free":[123],"survival.":[124],"Further,":[125],"pathways":[126],"involved":[127],"all":[131,161],"human":[134],"immunity.":[135],"Then,":[136],"exhibited":[139],"positively":[142,183],"correlated":[143,184],"DCs,":[145],"CD4+":[146],"T":[147],"cells,":[148],"neutrophils,":[149],"macrophages":[151],"most":[153,186],"cancers,":[154,166],"but":[155],"had":[156],"almost":[157],"correlation":[159],"cells":[163],"some":[165],"which":[167],"might":[168],"mean":[169],"that":[170],"hardly":[172],"affects":[173],"microenvironment":[176],"these":[178],"cancers.":[179],"known":[187],"immunomodulatory":[188],"genes,":[189],"especially":[190],"CCR1,":[191],"CCR5,":[192],"PDCD1LG2,":[193],"CD86.":[195],"Totally,":[196],"our":[197],"work":[198],"provided":[199],"new":[200],"insights":[201],"theoretical":[203],"basis":[204],"target.":[210]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
