{"id":"https://openalex.org/W4313525406","doi":"https://doi.org/10.1109/bibm55620.2022.9995711","title":"Genetic algorithm application for the prediction of potential SARS-CoV-2 new variant of concern","display_name":"Genetic algorithm application for the prediction of potential SARS-CoV-2 new variant of concern","publication_year":2022,"publication_date":"2022-12-06","ids":{"openalex":"https://openalex.org/W4313525406","doi":"https://doi.org/10.1109/bibm55620.2022.9995711"},"language":"en","primary_location":{"id":"doi:10.1109/bibm55620.2022.9995711","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm55620.2022.9995711","pdf_url":null,"source":{"id":"https://openalex.org/S4363607730","display_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085018122","display_name":"Avisa Maleki","orcid":"https://orcid.org/0000-0001-6956-8196"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Avisa Maleki","raw_affiliation_strings":["University of Catania,Department of Mathematics and Computer Science,Catania,Italy","Department of Mathematics and Computer Science, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Catania,Department of Mathematics and Computer Science,Catania,Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Mathematics and Computer Science, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076050008","display_name":"Alvaro Ras-Carmona","orcid":"https://orcid.org/0000-0003-1644-6878"},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alvaro Ras-Carmona","raw_affiliation_strings":["University Complutense of Madrid,Faculty of Medicine,Department of Immunology,Madrid,Spain","Department of Immunology, Faculty of Medicine, University Complutense of Madrid, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Complutense of Madrid,Faculty of Medicine,Department of Immunology,Madrid,Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"Department of Immunology, Faculty of Medicine, University Complutense of Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083311782","display_name":"Valentina Di Salvatore","orcid":"https://orcid.org/0000-0001-5576-3070"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Di Salvatore","raw_affiliation_strings":["University of Catania,Department of Drug and Health Sciences,Catania,Italy","Department of Drug and Health Sciences, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Catania,Department of Drug and Health Sciences,Catania,Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Drug and Health Sciences, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004880055","display_name":"Giulia Russo","orcid":"https://orcid.org/0000-0001-6616-7856"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Russo","raw_affiliation_strings":["University of Catania,Department of Drug and Health Sciences,Catania,Italy","Department of Drug and Health Sciences, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Catania,Department of Drug and Health Sciences,Catania,Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Drug and Health Sciences, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039844215","display_name":"Elena Crispino","orcid":"https://orcid.org/0000-0001-9289-4926"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Crispino","raw_affiliation_strings":["University of Catania,Department of Biomedicine and Bioinformatic,Catania,Italy","Department of Biomedicine and Bioinformatic, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Catania,Department of Biomedicine and Bioinformatic,Catania,Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Biomedicine and Bioinformatic, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044340074","display_name":"Francesco Pappalardo","orcid":"https://orcid.org/0000-0003-1668-3320"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Pappalardo","raw_affiliation_strings":["University of Catania,Department of Mathematics and Computer Science,Catania,Italy","Department of Mathematics and Computer Science, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Catania,Department of Mathematics and Computer Science,Catania,Italy","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Mathematics and Computer Science, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4802,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.70325619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"9","issue":null,"first_page":"3549","last_page":"3551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10494","display_name":"Plant Virus Research Studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10494","display_name":"Plant Virus Research Studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unavailability","display_name":"Unavailability","score":0.9168335795402527},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.6042287945747375},{"id":"https://openalex.org/keywords/transmissibility","display_name":"Transmissibility (structural dynamics)","score":0.4880017340183258},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4801570773124695},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4580475687980652},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4550238251686096},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.43678438663482666},{"id":"https://openalex.org/keywords/spike-protein","display_name":"Spike Protein","score":0.42525601387023926},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.42519354820251465},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"Mutation rate","score":0.4229198098182678},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3935122489929199},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.37532269954681396},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3734956979751587},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.359293669462204},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1967557966709137},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1763581931591034},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.17174071073532104},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.15124326944351196},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.15042972564697266},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10228085517883301}],"concepts":[{"id":"https://openalex.org/C2780505938","wikidata":"https://www.wikidata.org/wiki/Q17093282","display_name":"Unavailability","level":2,"score":0.9168335795402527},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6042287945747375},{"id":"https://openalex.org/C16683452","wikidata":"https://www.wikidata.org/wiki/Q7834601","display_name":"Transmissibility (structural dynamics)","level":4,"score":0.4880017340183258},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4801570773124695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4580475687980652},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4550238251686096},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.43678438663482666},{"id":"https://openalex.org/C2909509916","wikidata":"https://www.wikidata.org/wiki/Q22329850","display_name":"Spike Protein","level":5,"score":0.42525601387023926},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.42519354820251465},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.4229198098182678},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3935122489929199},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.37532269954681396},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3734956979751587},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.359293669462204},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1967557966709137},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1763581931591034},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17174071073532104},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.15124326944351196},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.15042972564697266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10228085517883301},{"id":"https://openalex.org/C198394728","wikidata":"https://www.wikidata.org/wiki/Q3695508","display_name":"Vibration","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C45799244","wikidata":"https://www.wikidata.org/wiki/Q109968206","display_name":"Vibration isolation","level":3,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm55620.2022.9995711","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm55620.2022.9995711","pdf_url":null,"source":{"id":"https://openalex.org/S4363607730","display_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8799999952316284}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1999613945","https://openalex.org/W2341550404","https://openalex.org/W2483031229","https://openalex.org/W3030005872","https://openalex.org/W3092452771","https://openalex.org/W3127977107","https://openalex.org/W3204169119"],"related_works":["https://openalex.org/W2146397496","https://openalex.org/W2076383445","https://openalex.org/W2592888218","https://openalex.org/W2136281516","https://openalex.org/W2025340064","https://openalex.org/W4384665577","https://openalex.org/W4231831369","https://openalex.org/W2097774084","https://openalex.org/W2606677068","https://openalex.org/W2120838291"],"abstract_inverted_index":{"The":[0,43,88],"COVID-19":[1],"pandemic":[2],"motivated":[3],"an":[4,67],"intense":[5],"debate":[6],"over":[7],"high":[8],"transmissibility":[9],"and":[10,20,32,80,133,146,165],"unavailability":[11],"of":[12,41,45,53,62,70,84,98,101,117,152,183],"effective":[13],"vaccine":[14],"to":[15,38,59,75,121,135,171],"cover":[16],"all":[17],"existent":[18],"variants,":[19],"also":[21],"has":[22],"raised":[23],"critical":[24],"questions,":[25],"such":[26],"as":[27],"concerns":[28,102],"about":[29],"new":[30,99,149],"mutations":[31,93],"genetic":[33,105],"recombination":[34],"that":[35,94,129],"could":[36],"lead":[37],"novel":[39],"variants":[40,100],"concerns.":[42],"density":[44],"mutation":[46,71],"observed":[47],"in":[48],"the":[49,60,82,92,114,153,156,180],"different":[50,125],"residue":[51],"indices":[52],"spike":[54,119],"protein":[55,120,140,160],"sequence,":[56],"may":[57,95],"correlate":[58],"speed":[61],"virus":[63,78],"distribution.":[64],"Therefore,":[65],"predicting":[66],"accurate":[68],"determination":[69],"rates":[72],"is":[73,176],"essential":[74],"comprehend":[76],"this":[77,109,174],"evolution":[79],"assess":[81],"risk":[83],"emergent":[85],"infectious":[86],"disease.":[87],"current":[89],"study":[90],"predicts":[91],"be":[96],"cause":[97],"using":[103],"a":[104,168],"algorithm":[106],"approach.":[107],"In":[108],"regard,":[110],"we":[111],"mutated":[112],"randomly":[113],"wild-type":[115],"sequence":[116,175],"SARS-CoV-2":[118],"generate":[122],"first":[123],"100":[124],"sequences":[126,154],"(initial":[127],"population)":[128],"were":[130],"modelled":[131],"individually":[132],"used":[134],"evaluate":[136],"their":[137],"discrete":[138,158],"optimized":[139,159],"energy":[141,161],"score.":[142],"After":[143],"applying":[144],"cross-over":[145],"breeding":[147],"200":[148],"generations,":[150],"one":[151],"with":[155],"lowest":[157],"score":[162],"was":[163],"identified":[164],"chosen":[166],"for":[167,178],"further":[169],"analysis":[170],"realize":[172],"whether":[173],"potential":[177],"being":[179],"next":[181],"variant":[182],"concern.":[184]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}