{"id":"https://openalex.org/W4313527204","doi":"https://doi.org/10.1109/bibm55620.2022.9995557","title":"Genetic and phenotypic relationships between coronary atherosclerotic heart disease and electrocardiographic traits","display_name":"Genetic and phenotypic relationships between coronary atherosclerotic heart disease and electrocardiographic traits","publication_year":2022,"publication_date":"2022-12-06","ids":{"openalex":"https://openalex.org/W4313527204","doi":"https://doi.org/10.1109/bibm55620.2022.9995557"},"language":"en","primary_location":{"id":"doi:10.1109/bibm55620.2022.9995557","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm55620.2022.9995557","pdf_url":null,"source":{"id":"https://openalex.org/S4363607730","display_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10072/421512","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101656664","display_name":"Xinfeng Wang","orcid":"https://orcid.org/0000-0003-0911-7312"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinfeng Wang","raw_affiliation_strings":["Sun Yat-sen University,Key Laboratory of Machine Intelligence and Advanced Computing of MOE School of Computer Science and Engineering,Guangzhou,China","Key Laboratory of Machine Intelligence and Advanced Computing of MOE School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University,Key Laboratory of Machine Intelligence and Advanced Computing of MOE School of Computer Science and Engineering,Guangzhou,China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Key Laboratory of Machine Intelligence and Advanced Computing of MOE School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100461124","display_name":"Haoyang Zhang","orcid":"https://orcid.org/0000-0002-6937-7936"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoyang Zhang","raw_affiliation_strings":["Sun Yat-sen University,Key Laboratory of Machine Intelligence and Advanced Computing of MOE School of Computer Science and Engineering,Guangzhou,China","Key Laboratory of Machine Intelligence and Advanced Computing of MOE School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University,Key Laboratory of Machine Intelligence and Advanced Computing of MOE School of Computer Science and Engineering,Guangzhou,China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Key Laboratory of Machine Intelligence and Advanced Computing of MOE School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013347037","display_name":"Xuehao Xiu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuehao Xiu","raw_affiliation_strings":["Sun Yat-sen Memorial Hospital,Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Medical Research Center,Guangzhou,China","Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Medical Research Center, Sun Yat-sen Memorial Hospital, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Sun Yat-sen Memorial Hospital,Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Medical Research Center,Guangzhou,China","institution_ids":["https://openalex.org/I4210097354","https://openalex.org/I157773358"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Medical Research Center, Sun Yat-sen Memorial Hospital, Guangzhou, China","institution_ids":["https://openalex.org/I4210097354","https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029848149","display_name":"Mengling Qi","orcid":"https://orcid.org/0000-0003-4956-2031"},"institutions":[{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengling Qi","raw_affiliation_strings":["Sun Yat-sen Memorial Hospital,Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Medical Research Center,Guangzhou,China","Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Medical Research Center, Sun Yat-sen Memorial Hospital, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Sun Yat-sen Memorial Hospital,Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Medical Research Center,Guangzhou,China","institution_ids":["https://openalex.org/I4210097354","https://openalex.org/I157773358"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Medical Research Center, Sun Yat-sen Memorial Hospital, Guangzhou, China","institution_ids":["https://openalex.org/I4210097354","https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023539493","display_name":"Yuedong Yang","orcid":"https://orcid.org/0000-0002-6782-2813"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuedong Yang","raw_affiliation_strings":["Sun Yat-sen University,Key Laboratory of Machine Intelligence and Advanced Computing of MOE School of Computer Science and Engineering,Guangzhou,China","Key Laboratory of Machine Intelligence and Advanced Computing of MOE School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Sun Yat-sen University,Key Laboratory of Machine Intelligence and Advanced Computing of MOE School of Computer Science and Engineering,Guangzhou,China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Key Laboratory of Machine Intelligence and Advanced Computing of MOE School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029051152","display_name":"Huiying Zhao","orcid":"https://orcid.org/0000-0001-9134-536X"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiying Zhao","raw_affiliation_strings":["Sun Yat-sen Memorial Hospital,Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Medical Research Center,Guangzhou,China","Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Medical Research Center, Sun Yat-sen Memorial Hospital, Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Sun Yat-sen Memorial Hospital,Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Medical Research Center,Guangzhou,China","institution_ids":["https://openalex.org/I4210097354","https://openalex.org/I157773358"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Medical Research Center, Sun Yat-sen Memorial Hospital, Guangzhou, China","institution_ids":["https://openalex.org/I4210097354","https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5101656664"],"corresponding_institution_ids":["https://openalex.org/I157773358"],"apc_list":null,"apc_paid":null,"fwci":0.9278,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.781893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.9007242918014526},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.501692533493042},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.44692865014076233},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3821450471878052},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2865997850894928},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2672337293624878},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14132875204086304},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.11556699872016907},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.10453543066978455},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"Genetic variants","score":0.09477663040161133}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9007242918014526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.501692533493042},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.44692865014076233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3821450471878052},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2865997850894928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2672337293624878},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14132875204086304},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.11556699872016907},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.10453543066978455},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.09477663040161133}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibm55620.2022.9995557","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm55620.2022.9995557","pdf_url":null,"source":{"id":"https://openalex.org/S4363607730","display_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},{"id":"pmh:oai:research-repository.griffith.edu.au:10072/421512","is_oa":true,"landing_page_url":"http://hdl.handle.net/10072/421512","pdf_url":null,"source":{"id":"https://openalex.org/S4306402548","display_name":"Griffith Research Online (Griffith University, Queensland, Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I11701301","host_organization_name":"Griffith University","host_organization_lineage":["https://openalex.org/I11701301"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference output"}],"best_oa_location":{"id":"pmh:oai:research-repository.griffith.edu.au:10072/421512","is_oa":true,"landing_page_url":"http://hdl.handle.net/10072/421512","pdf_url":null,"source":{"id":"https://openalex.org/S4306402548","display_name":"Griffith Research Online (Griffith University, Queensland, Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I11701301","host_organization_name":"Griffith University","host_organization_lineage":["https://openalex.org/I11701301"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference output"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320337504","display_name":"Research and Development","ror":"https://ror.org/027s68j25"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1870381380","https://openalex.org/W1966775465","https://openalex.org/W1997890715","https://openalex.org/W2067339233","https://openalex.org/W2073101927","https://openalex.org/W2082704080","https://openalex.org/W2100355237","https://openalex.org/W2102045006","https://openalex.org/W2109625917","https://openalex.org/W2117752747","https://openalex.org/W2120597207","https://openalex.org/W2153860431","https://openalex.org/W2161633633","https://openalex.org/W2171777347","https://openalex.org/W2198755677","https://openalex.org/W2328393125","https://openalex.org/W2409134270","https://openalex.org/W2529241974","https://openalex.org/W2565799880","https://openalex.org/W2604710715","https://openalex.org/W2622635054","https://openalex.org/W2766399429","https://openalex.org/W2807295499","https://openalex.org/W2818417770","https://openalex.org/W2848386833","https://openalex.org/W2949543964","https://openalex.org/W2989809306","https://openalex.org/W3027865872","https://openalex.org/W3045441625","https://openalex.org/W3120801339","https://openalex.org/W3127637041","https://openalex.org/W3137632058","https://openalex.org/W3196938045","https://openalex.org/W4220966186","https://openalex.org/W4250024550","https://openalex.org/W4253754191","https://openalex.org/W4284957964","https://openalex.org/W4293694877","https://openalex.org/W4399647672","https://openalex.org/W6810287486","https://openalex.org/W6869608176"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W2586801360","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Observational":[0],"studies":[1],"have":[2,103],"revealed":[3,133],"that":[4],"Coronary":[5],"Atherosclerotic":[6],"Heart":[7],"Disease":[8],"(CAHD)":[9],"is":[10],"associated":[11,123],"with":[12,99,107,124],"abnormal":[13],"electrocardiogram":[14],"(ECG)":[15],"traits.":[16],"However,":[17],"it":[18],"remains":[19],"unclear":[20],"whether":[21],"there":[22],"are":[23],"genetic":[24,33,83,143],"correlations":[25,34],"between":[26,39,85,127],"ECG":[27,42,73,89,96,140],"and":[28,35,41,48,72,87,101,129],"CAHD.":[29],"Here,":[30],"we":[31],"explored":[32],"putative":[36,134],"causal":[37,82,135],"relationships":[38],"CAHD":[40,66,86,105,128,138,151],"by":[43],"performing":[44],"Mendelian":[45,115],"randomization":[46,116],"(MR)":[47],"Polygenic":[49],"risk":[50,106,121,152],"score":[51],"(PRS)":[52],"analyses":[53],"on":[54,139],"the":[55,92,125,132,147,154],"summary":[56,113],"statistics":[57],"from":[58],"a":[59,81],"large-scale":[60],"genome-wide":[61],"association":[62],"study":[63],"(GWAS)":[64],"for":[65],"(FinnGen:":[67],"Ncase":[68],"23363,":[69],"Ncontrol":[70],"187840)":[71],"traits":[74,90,97,141],"(UK":[75],"Biobank:":[76],"Ncase=1137,":[77],"Ncontrol=40823).":[78],"Results":[79],"showed":[80],"relationship":[84],"six":[88],"in":[91],"lead":[93],"V6.":[94],"These":[95],"combining":[98],"age":[100],"gender":[102],"predicted":[104],"an":[108],"AUC":[109],"of":[110,137,149],"0.76.":[111],"Further":[112],"data-based":[114],"(SMR)":[117],"analysis":[118],"identified":[119],"11":[120],"genes":[122],"causality":[126],"ECG.":[130,155],"Thus,":[131],"effects":[136],"provide":[142],"evidence":[144],"to":[145],"support":[146],"importance":[148],"monitoring":[150],"through":[153]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2025-12-23T23:11:35.936235","created_date":"2025-10-10T00:00:00"}