{"id":"https://openalex.org/W4313525574","doi":"https://doi.org/10.1109/bibm55620.2022.9995413","title":"DSHP: A Novel Sequence Based Deep Learning Prediction Model for HPV Integration Site","display_name":"DSHP: A Novel Sequence Based Deep Learning Prediction Model for HPV Integration Site","publication_year":2022,"publication_date":"2022-12-06","ids":{"openalex":"https://openalex.org/W4313525574","doi":"https://doi.org/10.1109/bibm55620.2022.9995413"},"language":"en","primary_location":{"id":"doi:10.1109/bibm55620.2022.9995413","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm55620.2022.9995413","pdf_url":null,"source":{"id":"https://openalex.org/S4363607730","display_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103082459","display_name":"Tan Xian","orcid":"https://orcid.org/0000-0002-8911-4703"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xian Tan","raw_affiliation_strings":["Northeast Normal University,School of information science and technology,Changchun,China","School of information science and technology, Northeast Normal University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Normal University,School of information science and technology,Changchun,China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"School of information science and technology, Northeast Normal University, Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100787363","display_name":"Yiping Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiping Sun","raw_affiliation_strings":["Northeast Normal University,School of information science and technology,Changchun,China","School of information science and technology, Northeast Normal University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Normal University,School of information science and technology,Changchun,China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"School of information science and technology, Northeast Normal University, Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100592833","display_name":"Shijie Fan","orcid":"https://orcid.org/0009-0009-4252-5570"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijie Fan","raw_affiliation_strings":["Northeast Normal University,School of information science and technology,Changchun,China","School of information science and technology, Northeast Normal University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Normal University,School of information science and technology,Changchun,China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"School of information science and technology, Northeast Normal University, Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018063786","display_name":"Yanhe Wang","orcid":"https://orcid.org/0000-0003-1638-3125"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhe Wang","raw_affiliation_strings":["Northeast Normal University,School of information science and technology,Changchun,China","School of information science and technology, Northeast Normal University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Normal University,School of information science and technology,Changchun,China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"School of information science and technology, Northeast Normal University, Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100636096","display_name":"Jingbo Zhang","orcid":"https://orcid.org/0000-0002-5683-9660"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingbo Zhang","raw_affiliation_strings":["Northeast Normal University,School of information science and technology,Changchun,China","School of information science and technology, Northeast Normal University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Normal University,School of information science and technology,Changchun,China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"School of information science and technology, Northeast Normal University, Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101324580","display_name":"Pingping Sun","orcid":"https://orcid.org/0000-0002-8446-5598"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pingping Sun","raw_affiliation_strings":["Northeast Normal University,School of information science and technology,Changchun,China","School of information science and technology, Northeast Normal University, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Normal University,School of information science and technology,Changchun,China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"School of information science and technology, Northeast Normal University, Changchun, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101765974","display_name":"Zhiqiang Ma","orcid":"https://orcid.org/0000-0001-7568-3588"},"institutions":[{"id":"https://openalex.org/I4210087986","display_name":"Changchun Discovery Sciences (China)","ror":"https://ror.org/007e7b187","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210087986"]},{"id":"https://openalex.org/I49232843","display_name":"Changchun University","ror":"https://ror.org/02an57k10","country_code":"CN","type":"education","lineage":["https://openalex.org/I49232843"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqiang Ma","raw_affiliation_strings":["School of sciences Changchun Humanities and Sciences College,Changchun,China","School of sciences Changchun Humanities and Sciences College, Changchun, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of sciences Changchun Humanities and Sciences College,Changchun,China","institution_ids":["https://openalex.org/I49232843"]},{"raw_affiliation_string":"School of sciences Changchun Humanities and Sciences College, Changchun, China","institution_ids":["https://openalex.org/I4210087986"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4391,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.64122738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"561","last_page":"566"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.7032265067100525},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.648479163646698},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5416934490203857},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5204315781593323},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.49750688672065735},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4951113760471344},{"id":"https://openalex.org/keywords/data-integration","display_name":"Data integration","score":0.46486979722976685},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.448896199464798},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.44866830110549927},{"id":"https://openalex.org/keywords/code","display_name":"Code (set theory)","score":0.42049527168273926},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.27839547395706177},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.2759641408920288},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23771467804908752},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12860503792762756}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7032265067100525},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.648479163646698},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5416934490203857},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5204315781593323},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.49750688672065735},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4951113760471344},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.46486979722976685},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.448896199464798},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.44866830110549927},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.42049527168273926},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27839547395706177},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2759641408920288},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23771467804908752},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12860503792762756},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm55620.2022.9995413","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm55620.2022.9995413","pdf_url":null,"source":{"id":"https://openalex.org/S4363607730","display_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6200000047683716,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1988581590","https://openalex.org/W2005919148","https://openalex.org/W2017474562","https://openalex.org/W2081116295","https://openalex.org/W2082481679","https://openalex.org/W2089963048","https://openalex.org/W2107770226","https://openalex.org/W2138790911","https://openalex.org/W2147835058","https://openalex.org/W2156876426","https://openalex.org/W2157358322","https://openalex.org/W2163605009","https://openalex.org/W2473141600","https://openalex.org/W2611586225","https://openalex.org/W2921372942","https://openalex.org/W2972911304","https://openalex.org/W3093048084","https://openalex.org/W3131337505","https://openalex.org/W4200395890","https://openalex.org/W4205622093","https://openalex.org/W4220791315","https://openalex.org/W4287285867","https://openalex.org/W6684191040","https://openalex.org/W6783965133","https://openalex.org/W6791288937"],"related_works":["https://openalex.org/W3129816939","https://openalex.org/W2912862995","https://openalex.org/W2985427592","https://openalex.org/W2101501829","https://openalex.org/W2400569965","https://openalex.org/W2060263731","https://openalex.org/W2003194288","https://openalex.org/W391093122","https://openalex.org/W1521239975","https://openalex.org/W4361305867"],"abstract_inverted_index":{"HPV,":[0],"a":[1,112,126,187],"significant":[2],"hazard":[3],"to":[4,23],"human":[5],"health,":[6],"is":[7,91,105],"the":[8,44,50,56,61,66,73,82,97,136,139,150,153,167,177,182],"primary":[9],"cause":[10],"of":[11,19,63,68,75,100,128,130,143,157,169,179],"many":[12,27],"cancers.":[13],"The":[14,163,193],"proteins":[15],"E6":[16],"and":[17,43,65,77,95,141,147,155,161,185,195],"E7":[18],"HPV":[20,35,64,85,101,118],"are":[21,29,145,159,197],"known":[22],"damage":[24],"oncogenes,":[25],"but":[26],"mechanisms":[28],"still":[30],"unknown.":[31],"Research":[32,54],"reveals":[33],"that":[34],"can":[36,59],"integrate":[37],"its":[38,93],"genome":[39],"into":[40],"host":[41],"genes,":[42],"integration":[45,57,86,102,119],"mechanism":[46,58],"strongly":[47],"depends":[48],"on":[49,55,84],"local":[51],"genomic":[52],"environment.":[53],"deepen":[60],"understanding":[62],"development":[67],"vaccines,":[69],"thus":[70],"further":[71,175],"affecting":[72],"cure":[74],"cancers":[76],"other":[78],"related":[79],"diseases.":[80],"However,":[81],"research":[83],"sites":[87],"in":[88,92,149,181],"silico":[89],"experiments":[90,174],"infancy,":[94],"improving":[96],"model":[98,116],"performance":[99,164],"site":[103,120],"predictors":[104],"challenging.":[106],"In":[107,135],"this":[108],"work,":[109],"we":[110],"propose":[111],"novel":[113],"deep":[114],"learning":[115],"for":[117,189],"prediction":[121,183,191],"named":[122],"DSHP.":[123,170],"DSHP":[124,144,158],"uses":[125],"variety":[127],"features":[129,180],"DNA":[131],"sequences":[132],"as":[133],"input.":[134],"5-fold":[137],"cross-validation,":[138,152],"ACC":[140,154],"AUC":[142,156],"0.914":[146],"0.934;":[148],"10-fold":[151],"0.933":[160],"0.941.":[162],"fully":[165],"illustrates":[166],"effectiveness":[168],"Moreover,":[171],"our":[172],"ablation":[173],"explain":[176],"importance":[178],"process,":[184],"provide":[186],"reference":[188],"future":[190],"research.":[192],"data":[194],"code":[196],"available":[198],"at:":[199],"https://github.com/xtnenu/DSHP.":[200]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
