{"id":"https://openalex.org/W4313525564","doi":"https://doi.org/10.1109/bibm55620.2022.9995174","title":"BP-DDI: Drug-drug interaction prediction based on biological information and pharmacological text","display_name":"BP-DDI: Drug-drug interaction prediction based on biological information and pharmacological text","publication_year":2022,"publication_date":"2022-12-06","ids":{"openalex":"https://openalex.org/W4313525564","doi":"https://doi.org/10.1109/bibm55620.2022.9995174"},"language":"en","primary_location":{"id":"doi:10.1109/bibm55620.2022.9995174","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm55620.2022.9995174","pdf_url":null,"source":{"id":"https://openalex.org/S4363607730","display_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020923075","display_name":"Mingliang Dou","orcid":"https://orcid.org/0009-0001-1213-1070"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingliang Dou","raw_affiliation_strings":["Tianjin University,College of Intelligence and Computing,Tianjin,China","College of Intelligence and Computing, Tianjin University, Tianjin, China"],"affiliations":[{"raw_affiliation_string":"Tianjin University,College of Intelligence and Computing,Tianjin,China","institution_ids":["https://openalex.org/I162868743"]},{"raw_affiliation_string":"College of Intelligence and Computing, Tianjin University, Tianjin, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100321746","display_name":"Han Han","orcid":"https://orcid.org/0000-0001-8280-6056"},"institutions":[{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Han","raw_affiliation_strings":["Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China","Chinese Academy of Sciences, Shenzhen Institute of Advanced Technology, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China","institution_ids":["https://openalex.org/I4210145761","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Chinese Academy of Sciences, Shenzhen Institute of Advanced Technology, Shenzhen, China","institution_ids":["https://openalex.org/I4210145761","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103253915","display_name":"Genlang Chen","orcid":"https://orcid.org/0000-0003-4381-7988"},"institutions":[{"id":"https://openalex.org/I159389169","display_name":"Ningbo University of Technology","ror":"https://ror.org/037dym702","country_code":"CN","type":"education","lineage":["https://openalex.org/I159389169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Genlang Chen","raw_affiliation_strings":["NingboTech University,School of Computer and Data Engineering,Ningbo,China","School of Computer and Data Engineering, NingboTech University, Ningbo, China"],"affiliations":[{"raw_affiliation_string":"NingboTech University,School of Computer and Data Engineering,Ningbo,China","institution_ids":["https://openalex.org/I159389169"]},{"raw_affiliation_string":"School of Computer and Data Engineering, NingboTech University, Ningbo, China","institution_ids":["https://openalex.org/I159389169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100702161","display_name":"Fei Guo","orcid":"https://orcid.org/0000-0001-8346-0798"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Guo","raw_affiliation_strings":["Central South University,School of Computer Science and Engineering,Changsha,China","School of Computer Science and Engineering, Central South University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"Central South University,School of Computer Science and Engineering,Changsha,China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001619694","display_name":"Jijun Tang","orcid":"https://orcid.org/0000-0002-6377-536X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jijun Tang","raw_affiliation_strings":["University of South Carolina,College of Engineering and Computing,U.S","College of Engineering and Computing, University of South Carolina, U.S"],"affiliations":[{"raw_affiliation_string":"University of South Carolina,College of Engineering and Computing,U.S","institution_ids":[]},{"raw_affiliation_string":"College of Engineering and Computing, University of South Carolina, U.S","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5020923075"],"corresponding_institution_ids":["https://openalex.org/I162868743"],"apc_list":null,"apc_paid":null,"fwci":1.5581,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.84653465,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"46","issue":null,"first_page":"410","last_page":"415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9581000208854675,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9079999923706055,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drugbank","display_name":"DrugBank","score":0.9109070301055908},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6101375222206116},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.594938337802887},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5617361068725586},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"Pharmacovigilance","score":0.44443479180336},{"id":"https://openalex.org/keywords/systems-pharmacology","display_name":"Systems pharmacology","score":0.43890708684921265},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4171035885810852},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3475674092769623},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2936326861381531},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.28073519468307495},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.19808098673820496},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1575237214565277}],"concepts":[{"id":"https://openalex.org/C155261790","wikidata":"https://www.wikidata.org/wiki/Q1122544","display_name":"DrugBank","level":3,"score":0.9109070301055908},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6101375222206116},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.594938337802887},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5617361068725586},{"id":"https://openalex.org/C57658597","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Pharmacovigilance","level":3,"score":0.44443479180336},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.43890708684921265},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4171035885810852},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3475674092769623},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2936326861381531},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28073519468307495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19808098673820496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1575237214565277}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm55620.2022.9995174","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm55620.2022.9995174","pdf_url":null,"source":{"id":"https://openalex.org/S4363607730","display_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335581","display_name":"Young Scientists Fund","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W2061136308","https://openalex.org/W2119002393","https://openalex.org/W2570516417","https://openalex.org/W2591704587","https://openalex.org/W2597646117","https://openalex.org/W2767891136","https://openalex.org/W2802200505","https://openalex.org/W2965993245","https://openalex.org/W2972392269","https://openalex.org/W2974658886","https://openalex.org/W3024894285","https://openalex.org/W3035011799","https://openalex.org/W3039265083","https://openalex.org/W3096828292","https://openalex.org/W3129758539","https://openalex.org/W3139253280","https://openalex.org/W3154229486","https://openalex.org/W3157889929","https://openalex.org/W3193170798","https://openalex.org/W3205082786","https://openalex.org/W3208102118","https://openalex.org/W3213715512","https://openalex.org/W4200227922","https://openalex.org/W4200351086","https://openalex.org/W4205463297","https://openalex.org/W4214819330","https://openalex.org/W4220960765","https://openalex.org/W6604129188","https://openalex.org/W6794146050","https://openalex.org/W6804145975"],"related_works":["https://openalex.org/W4214512798","https://openalex.org/W2802200505","https://openalex.org/W4386529428","https://openalex.org/W4298126268","https://openalex.org/W3035605175","https://openalex.org/W3159702495","https://openalex.org/W2176533785","https://openalex.org/W4285026760","https://openalex.org/W3115251532","https://openalex.org/W3174527492"],"abstract_inverted_index":{"In":[0,92,119],"the":[1,33,39,181,187],"treatment":[2],"of":[3,35,43,52,72,103,127,136,177,195,217],"many":[4],"diseases,":[5,80],"combination":[6],"drug":[7,106],"therapy":[8],"has":[9],"been":[10,114],"widely":[11],"used":[12],"and":[13,27,70,81,138,150,166,172,225],"achieved":[14],"good":[15],"clinical":[16],"efficacy.":[17],"However,":[18],"drug-drug":[19],"interaction":[20],"(DDI)":[21],"may":[22],"occur":[23],"between":[24],"multiple":[25,46],"drugs":[26,47],"pose":[28],"a":[29,101,140],"huge":[30],"threat":[31],"to":[32,85,90,94,116,153,201],"health":[34],"patients.":[36],"Therefore,":[37],"predicting":[38],"presence":[40],"or":[41,74],"absence":[42],"DDI":[44,59,117,155,203],"among":[45],"is":[48],"an":[49],"important":[50],"part":[51],"pharmacovigilance.":[53],"Currently,":[54],"various":[55],"computational":[56],"methods":[57,212],"for":[58],"prediction":[60,218],"usually":[61],"use":[62],"biological":[63,95,148,161,170,188],"information":[64,88,104,149],"such":[65],"as":[66,84],"molecular":[67],"structures,":[68],"targets":[69],"enzymes":[71],"drugs,":[73,79,137],"construct":[75],"heterogeneous":[76],"networks":[77],"about":[78,105],"genes,":[82],"so":[83],"obtain":[86],"abundant":[87],"related":[89],"drugs.":[91],"addition":[93],"data,":[96,171],"pharmacology":[97,128,183],"texts":[98,110,129],"also":[99],"contain":[100],"wealth":[102],"properties,":[107],"but":[108],"these":[109],"have":[111],"not":[112],"yet":[113],"applied":[115],"predictions.":[118],"this":[120],"study,":[121],"we":[122],"first":[123,159],"collect":[124],"six":[125],"types":[126,176,194,216],"from":[130,169,180],"DrugBank":[131],"that":[132,208],"can":[133,146],"reflect":[134],"properties":[135],"propose":[139],"novel":[141],"method":[142],"named":[143],"BP-DDI":[144,158,209,220],"which":[145],"combine":[147],"pharmacological":[151,196],"text":[152,178,184,197],"realize":[154],"event":[156],"prediction.":[157],"extracts":[160,174],"features":[162,165,179,189,198],"(chemical":[163],"substructure":[164],"target":[167],"features)":[168],"then":[173],"specific":[175],"collected":[182],"data.":[185],"Finally,":[186],"are":[190],"fused":[191],"with":[192],"different":[193],"in":[199],"order":[200],"predict":[202],"events.":[204],"Our":[205],"experiments":[206],"demonstrate":[207],"outperforms":[210],"existing":[211],"on":[213,223,228],"all":[214],"three":[215],"tasks.":[219],"achieves":[221,226],"0.9052":[222],"ACC,":[224],"0.9612":[227],"AUPR.":[229]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5}],"updated_date":"2025-12-21T01:58:51.020947","created_date":"2025-10-10T00:00:00"}