{"id":"https://openalex.org/W4313526959","doi":"https://doi.org/10.1109/bibm55620.2022.9995160","title":"A Feature Weighted Tracking Method for 3D Neutrophils in Time-lapse Microscopy","display_name":"A Feature Weighted Tracking Method for 3D Neutrophils in Time-lapse Microscopy","publication_year":2022,"publication_date":"2022-12-06","ids":{"openalex":"https://openalex.org/W4313526959","doi":"https://doi.org/10.1109/bibm55620.2022.9995160"},"language":"en","primary_location":{"id":"doi:10.1109/bibm55620.2022.9995160","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm55620.2022.9995160","pdf_url":null,"source":{"id":"https://openalex.org/S4363607730","display_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100369916","display_name":"Chen Li","orcid":"https://orcid.org/0000-0003-1545-8885"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I210716285","display_name":"University of Applied Sciences Leiden","ror":"https://ror.org/0093src13","country_code":"NL","type":"education","lineage":["https://openalex.org/I210716285"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Chen Li","raw_affiliation_strings":["Leiden University,LIACS,Leiden,the Netherlands","LIACS, Leiden University, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University,LIACS,Leiden,the Netherlands","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I210716285"]},{"raw_affiliation_string":"LIACS, Leiden University, Leiden, the Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054194266","display_name":"Wilson W.C. Yiu","orcid":null},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I210716285","display_name":"University of Applied Sciences Leiden","ror":"https://ror.org/0093src13","country_code":"NL","type":"education","lineage":["https://openalex.org/I210716285"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wilson W.C. Yiu","raw_affiliation_strings":["Leiden University,LIACS,Leiden,the Netherlands","LIACS, Leiden University, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University,LIACS,Leiden,the Netherlands","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I210716285"]},{"raw_affiliation_string":"LIACS, Leiden University, Leiden, the Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005738691","display_name":"Wanbin Hu","orcid":"https://orcid.org/0000-0003-3660-2700"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I210716285","display_name":"University of Applied Sciences Leiden","ror":"https://ror.org/0093src13","country_code":"NL","type":"education","lineage":["https://openalex.org/I210716285"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wanbin Hu","raw_affiliation_strings":["Leiden University,IBL,Leiden,the Netherlands","IBL, Leiden University, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University,IBL,Leiden,the Netherlands","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I210716285"]},{"raw_affiliation_string":"IBL, Leiden University, Leiden, the Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100393055","display_name":"Lu Cao","orcid":"https://orcid.org/0000-0002-1847-068X"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I210716285","display_name":"University of Applied Sciences Leiden","ror":"https://ror.org/0093src13","country_code":"NL","type":"education","lineage":["https://openalex.org/I210716285"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lu Cao","raw_affiliation_strings":["Leiden University,LIACS,Leiden,the Netherlands","LIACS, Leiden University, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University,LIACS,Leiden,the Netherlands","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I210716285"]},{"raw_affiliation_string":"LIACS, Leiden University, Leiden, the Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022631255","display_name":"Fons J. Verbeek","orcid":"https://orcid.org/0000-0003-2445-8158"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I210716285","display_name":"University of Applied Sciences Leiden","ror":"https://ror.org/0093src13","country_code":"NL","type":"education","lineage":["https://openalex.org/I210716285"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Fons J. Verbeek","raw_affiliation_strings":["Leiden University,LIACS,Leiden,the Netherlands","LIACS, Leiden University, Leiden, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University,LIACS,Leiden,the Netherlands","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I210716285"]},{"raw_affiliation_string":"LIACS, Leiden University, Leiden, the Netherlands","institution_ids":["https://openalex.org/I121797337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31522956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":null,"first_page":"2196","last_page":"2202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10531","display_name":"Advanced Vision and Imaging","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6263545155525208},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5845252275466919},{"id":"https://openalex.org/keywords/tracking","display_name":"Tracking (education)","score":0.5659548044204712},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.5534840822219849},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5155977606773376},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4894222319126129},{"id":"https://openalex.org/keywords/interpolation","display_name":"Interpolation (computer graphics)","score":0.4689604341983795},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.44853171706199646},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.36034637689590454},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.1590191125869751}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6263545155525208},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5845252275466919},{"id":"https://openalex.org/C2775936607","wikidata":"https://www.wikidata.org/wiki/Q466845","display_name":"Tracking (education)","level":2,"score":0.5659548044204712},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.5534840822219849},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5155977606773376},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4894222319126129},{"id":"https://openalex.org/C137800194","wikidata":"https://www.wikidata.org/wiki/Q11713455","display_name":"Interpolation (computer graphics)","level":3,"score":0.4689604341983795},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.44853171706199646},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.36034637689590454},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.1590191125869751},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm55620.2022.9995160","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/bibm55620.2022.9995160","pdf_url":null,"source":{"id":"https://openalex.org/S4363607730","display_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1592919350","https://openalex.org/W1901129140","https://openalex.org/W2041359271","https://openalex.org/W2096590953","https://openalex.org/W2167279371","https://openalex.org/W2222512263","https://openalex.org/W2464708700","https://openalex.org/W2895732080","https://openalex.org/W2953094064","https://openalex.org/W2955521425","https://openalex.org/W2963093735","https://openalex.org/W2991053534","https://openalex.org/W3015600294","https://openalex.org/W3093776812","https://openalex.org/W3101361836","https://openalex.org/W3132609170","https://openalex.org/W3150322046","https://openalex.org/W3164139555","https://openalex.org/W3176098471","https://openalex.org/W3195254642","https://openalex.org/W3213222106","https://openalex.org/W4225006679","https://openalex.org/W6697068466"],"related_works":["https://openalex.org/W2084086966","https://openalex.org/W3037187668","https://openalex.org/W4234772502","https://openalex.org/W2023861399","https://openalex.org/W2380685755","https://openalex.org/W2252100032","https://openalex.org/W2963436428","https://openalex.org/W3171253712","https://openalex.org/W2171591485","https://openalex.org/W4386159726"],"abstract_inverted_index":{"Neutrophils":[0,5],"are":[1,6],"one":[2,7],"of":[3,8,25,35,39,48,70,82,101],"the":[4,9,19,23,36,68,80,99,105,128],"crucial":[10],"immune":[11,20],"cells.":[12],"It":[13],"plays":[14],"a":[15,60,109],"key":[16],"role":[17],"in":[18,50,63,104],"system":[21],"defending":[22],"invasion":[24],"harmful":[26],"particles,":[27],"such":[28],"as":[29],"viruses":[30],"and":[31,73,87,95],"bacteria.":[32],"The":[33,117],"analysis":[34],"dynamic":[37],"process":[38],"neutrophil":[40,56],"migration":[41],"helps":[42],"biologists":[43],"to":[44,52,67,97,127],"understand":[45],"underlying":[46],"mechanisms":[47],"neutrophils":[49],"response":[51],"wounding.":[53],"However,":[54],"accurate":[55],"tracking":[57,113,130],"is":[58,134],"still":[59],"challenging":[61],"task":[62],"3D":[64,91,112],"space":[65],"due":[66],"complexity":[69],"cell":[71,103],"morphology":[72],"behavior.":[74],"In":[75],"this":[76],"study,":[77],"we":[78],"improved":[79],"quality":[81],"raw":[83],"data":[84],"by":[85],"denoising":[86],"linear":[88],"interpolation.":[89],"A":[90],"U-Net":[92],"was":[93,115],"trained":[94],"used":[96],"detect":[98],"location":[100],"each":[102],"time-lapse":[106],"movie.":[107],"Subsequently,":[108],"feature":[110],"weighted":[111],"method":[114,123],"proposed.":[116],"experimental":[118],"results":[119],"show":[120],"that":[121],"our":[122],"performs":[124],"well":[125],"compared":[126],"existing":[129],"algorithm.":[131],"Our":[132],"pipeline":[133],"also":[135],"much":[136],"more":[137],"reproducible":[138],"than":[139],"other":[140],"state-of-arts.":[141]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
